PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17685602-4 2007 Elaborations involving substitutions of the 2 and 4 positions of the pyrimidine or pyridine ring and the 6 and 7 positions of the central pyrazine ring resulted in in vivo activity profiles which identified potent inhibitors of vascular endothelial growth factor (VEGF) induced vascular leakage. pyridine 83-91 vascular endothelial growth factor A Homo sapiens 228-262