PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28164578-10 2016 Changes in CDT level indicate disturbances in transferrin glycosylation in the course of alcoholic pancreatic diseases. 1,5,9-cyclododecatriene 11-14 transferrin Homo sapiens 46-57 26851349-1 2016 OBJECTIVES: Ethyl glucuronide in hair (hEtG) and serum carbohydrate deficient transferrin (%CDT) are valuable markers for alcohol abuse, but their diagnostic accuracy to monitor abstinence and relapse is unclear. 1,5,9-cyclododecatriene 92-95 transferrin Homo sapiens 78-89 26092603-0 2015 Evaluation of serum carbohydrate-deficient transferrin by HPLC and MALDI-TOF MS. BACKGROUND: The percentage of carbohydrate-deficient transferrin (%CDT) in serum is a marker of habitual alcohol intake that can be determined by antibody detection of abnormal disialo sugar chains at D432 and D630. 1,5,9-cyclododecatriene 148-151 transferrin Homo sapiens 134-145 26110815-5 2015 RESULTS: Percentage of carbohydrate deficient transferrin (%CDT) provided the highest diagnostic performance (area under the curve [AUC] 0.77) followed by gamma-glutamyl transferase (GGT) (AUC 0.68) to detect excessive drinkers. 1,5,9-cyclododecatriene 60-63 transferrin Homo sapiens 46-57 22878591-1 2012 AIMS: Carbohydrate-deficient transferrin (%CDT) is a well-established and highly specific biomarker for sustained heavy consumption of alcohol. 1,5,9-cyclododecatriene 43-46 transferrin Homo sapiens 29-40 21665994-2 2011 Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-deficient transferrin, CDT) are used as biomarkers of excessive alcohol intake. 1,5,9-cyclododecatriene 238-241 transferrin Homo sapiens 100-111 21665994-2 2011 Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-deficient transferrin, CDT) are used as biomarkers of excessive alcohol intake. 1,5,9-cyclododecatriene 238-241 transferrin Homo sapiens 141-152 21665994-2 2011 Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-deficient transferrin, CDT) are used as biomarkers of excessive alcohol intake. 1,5,9-cyclododecatriene 238-241 transferrin Homo sapiens 141-152 21665994-6 2011 Genome-wide single-nucleotide polymorphism (SNP) typing data were used to identify loci with significant associations with CDT as a percentage of total transferrin (CDT%). 1,5,9-cyclododecatriene 123-126 transferrin Homo sapiens 152-163 20697796-2 2010 We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. 1,5,9-cyclododecatriene 105-108 transferrin Homo sapiens 91-102 20599878-6 2010 A significant correlation between CDT values and transferrin concentration was found for the particle-enhanced immunonephelometric test (r: -0.311; p: 0.0009). 1,5,9-cyclododecatriene 34-37 transferrin Homo sapiens 49-60 20599878-7 2010 CONCLUSIONS: A high rate of positive CDT results was observed in HD patients with the particle-enhanced immunonephelometry and seems to be related to the low transferrin concentration. 1,5,9-cyclododecatriene 37-40 transferrin Homo sapiens 158-169 19426168-1 2009 BACKGROUND: The %carbohydrate deficient transferrin (%CDT) test offers objective evidence of unhealthy alcohol use but its cost-effectiveness in primary care conditions is unknown. 1,5,9-cyclododecatriene 54-57 transferrin Homo sapiens 40-51 18667524-0 2008 Automated measurement of carbohydrate-deficient transferrin using the Bio-Rad %CDT by the HPLC test on a Variant HPLC system: evaluation and comparison with other routine procedures. 1,5,9-cyclododecatriene 79-82 transferrin Homo sapiens 48-59 18024528-2 2008 Here we present our experience of CDG screening in children with a suspected metabolic disease by determination of serum percentage of carbohydrate-deficient transferrin (%CDT) in tandem with isoelectric focusing (IEF) analysis of Tf and alpha(1)-antitrypsin (alpha(1)-AT). 1,5,9-cyclododecatriene 172-175 transferrin Homo sapiens 158-169 17291470-1 2007 BACKGROUND: Carbohydrate-deficient transferrin (asialo-+monosialo-+disialotransferrin, CDT) is currently the most specific laboratory marker of chronic alcohol abuse. 1,5,9-cyclododecatriene 87-90 transferrin Homo sapiens 35-46 17407501-2 2007 In this study we report validation of the two combinations DOVER (DOctor VERified) and QUVER (QUestionnarie VERified) of the biological markers percent carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl-transferase (gamma-GT) to detect patients that have been identified by their physicians with at-risk drinking behavior. 1,5,9-cyclododecatriene 189-192 transferrin Homo sapiens 175-186 21768932-0 2007 Case studies of the utility of serum carbohydrate-deficient transferrin (%CDT) in the clinical management of alcoholics. 1,5,9-cyclododecatriene 74-77 transferrin Homo sapiens 60-71 21768932-1 2007 A laboratory test that measures the percentage of carbohydrate-deficient transferrin (%CDT) has been approved by the FDA for the detection of heavy alcohol use. 1,5,9-cyclododecatriene 87-90 transferrin Homo sapiens 73-84 16777120-5 2006 Compared with the use of the previous CEofix reagents for CDT under the same instrumental conditions, the resolution between disialo-Tf and trisialo-Tf is significantly higher (1.7 versus 1.4). 1,5,9-cyclododecatriene 58-61 transferrin Homo sapiens 133-135 16777120-5 2006 Compared with the use of the previous CEofix reagents for CDT under the same instrumental conditions, the resolution between disialo-Tf and trisialo-Tf is significantly higher (1.7 versus 1.4). 1,5,9-cyclododecatriene 58-61 transferrin Homo sapiens 149-151 16899040-3 2006 In this study, we report a new approach to combine the biological markers % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (gammaGT) to increase diagnostic properties to identify patients with at-risk drinking behavior. 1,5,9-cyclododecatriene 113-116 transferrin Homo sapiens 99-110 16178908-0 2005 Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia. 1,5,9-cyclododecatriene 49-52 transferrin Homo sapiens 35-46 16178908-1 2005 This study has investigated the serum levels of carbohydrate-deficient isoforms of transferrin (CDT) and sialic acid (SA) in iron-deficiency anemia (IDA). 1,5,9-cyclododecatriene 96-99 transferrin Homo sapiens 83-94 16178908-3 2005 CDT was estimated by anion-exchange chromatography on minicolumns followed by photometric detection of transferrin and was expressed as a percentage of total transferrin (%CDT). 1,5,9-cyclododecatriene 0-3 transferrin Homo sapiens 103-114 16178908-3 2005 CDT was estimated by anion-exchange chromatography on minicolumns followed by photometric detection of transferrin and was expressed as a percentage of total transferrin (%CDT). 1,5,9-cyclododecatriene 0-3 transferrin Homo sapiens 158-169 12711663-1 2003 AIMS: The analytical performance of the new Tina-quant % carbohydrate-deficient transferrin (%CDT) was assessed in a multicentre study on Roche/Hitachi analysers. 1,5,9-cyclododecatriene 94-97 transferrin Homo sapiens 80-91 12479087-6 2002 Among serum markers, only the relative amount of carbohydrate-deficient transferrin (s%CDT) has parameters sufficient for diagnostic use (ROC AUC 0.74, sensitivity 0.60, specificity 0.86). 1,5,9-cyclododecatriene 87-90 transferrin Homo sapiens 72-83 11166010-7 2000 RESULTS: Data from HPLC and isoelectric focusing indicate that the ChronAlco assay detects major parts of asialo, monosialo, and disialo transferrin as CDT while the CDT TIA yields CDT as the total of asialo, monosialo, disialo, and trisialo transferrin. 1,5,9-cyclododecatriene 152-155 transferrin Homo sapiens 137-148 11166010-9 2000 CONCLUSION: Including trisialo transferrin into the CDT fraction enlarges the analytical signal and therefore slightly improves assay precision but also results in a significant number of pathologic results in samples exhibiting physiologic levels of the classical CDT components asialo to disialo transferrin. 1,5,9-cyclododecatriene 265-268 transferrin Homo sapiens 31-42 10892586-1 2000 Transferrin sialoforms with fewer than three sialic acid residues (carbohydrate deficient transferrin; CDT) have been implicated as a marker of certain liver pathologies. 1,5,9-cyclododecatriene 103-106 transferrin Homo sapiens 0-11 10892586-3 2000 Using a DAB concentration of 3 mM, transferrin sialoforms were adequately resolved to allow for direct detection of CDT without extensive treatment of the sera. 1,5,9-cyclododecatriene 116-119 transferrin Homo sapiens 35-46 10846234-5 2000 A consensus has to be established concerning a reference method and the definition of the transferrin isoforms that should be included in the CDT. 1,5,9-cyclododecatriene 142-145 transferrin Homo sapiens 90-101 10522369-0 1999 [Carbohydrate-deficient transferrin (CDT) is modified by iron status: further reservations regarding the value of a new alcohol marker? 1,5,9-cyclododecatriene 37-40 transferrin Homo sapiens 24-35 11045170-1 1999 Assessment of carbohydrate-deficient serum transferrin CDT) is considered a very useful indicator of alcohol abuse. 1,5,9-cyclododecatriene 55-58 transferrin Homo sapiens 43-54 11045170-3 1999 In clinical practice most frequently assessment of the percentage ratio of CDT in transferrin is used. 1,5,9-cyclododecatriene 75-78 transferrin Homo sapiens 82-93 9475320-1 1997 Carbohydrate-deficient isoforms of transferrin (CDT) were examined in Guthrie cards from patients with galactosaemia before and during dietary treatment for up to 9 y. 1,5,9-cyclododecatriene 48-51 transferrin Homo sapiens 35-46 9463727-1 1997 A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detecting alcohol-dependent patients in a surgical ward. 1,5,9-cyclododecatriene 73-76 transferrin Homo sapiens 59-70 9372274-5 1997 A cut-off value of 3% carbohydrate deficient transferrin (CDT: disialo, monosialo, and asialo transferrin), results in a clinical sensitivity of 88% in a population consuming at least 70 g/day alcohol for a minimum of two weeks. 1,5,9-cyclododecatriene 58-61 transferrin Homo sapiens 45-56 9269862-0 1997 Increased carbohydrate-deficient transferrin during pregnancy and relation to sex hormones: %CDT will not yield false positive results. 1,5,9-cyclododecatriene 93-96 transferrin Homo sapiens 33-44 26735641-1 1997 Recent studies have demonstrated that the diagnostic performance of CDT measurements is influenced by variations in total transferrin concentration. 1,5,9-cyclododecatriene 68-71 transferrin Homo sapiens 122-133 8734848-3 1996 The changes in three sialylated proteins [Lp(a), alpha 1-antitrypsin (alpha 1-AT), and haptoglobin (Hp)] and in desialylated transferrin (CDT) were also determined in 14 patients. 1,5,9-cyclododecatriene 138-141 transferrin Homo sapiens 125-136 8844031-1 1996 We investigated %CDT (carbohydrate-deficient transferrin) in 92 ethanol-intoxicated alcohol-dependent patients after consecutive admission to hospital and followed the for 28 days under controlled conditions. 1,5,9-cyclododecatriene 17-20 transferrin Homo sapiens 45-56 7803257-1 1994 The concentration of carbohydrate-deficient transferrin in serum (CDT) has been used as a reliable indicator of recent alcohol consumption. 1,5,9-cyclododecatriene 66-69 transferrin Homo sapiens 44-55 8077351-1 1994 An elevated concentration of carbohydrate-deficient transferrin in serum (CDT) has been reported to indicate excessive ethanol consumption. 1,5,9-cyclododecatriene 74-77 transferrin Homo sapiens 52-63 8488959-1 1993 Carbohydrate-deficient transferrin, CDT, had previously been reported to be an excellent marker for alcoholism. 1,5,9-cyclododecatriene 36-39 transferrin Homo sapiens 23-34 1443784-4 1992 In English speaking countries, it is called carbohydrate deficient transferrin or CDT. 1,5,9-cyclododecatriene 82-85 transferrin Homo sapiens 67-78 2288734-2 1990 The method is based on the detection of a transferrin variant (carbohydrate deficient transferrin = CDT) in plasma of alcoholics. 1,5,9-cyclododecatriene 100-103 transferrin Homo sapiens 42-53 2288734-2 1990 The method is based on the detection of a transferrin variant (carbohydrate deficient transferrin = CDT) in plasma of alcoholics. 1,5,9-cyclododecatriene 100-103 transferrin Homo sapiens 86-97 2288734-3 1990 The determination of CDT, the presence of which is characteristic for chronic alcoholism, is performed in three steps: The plasma proteins are separated by polyacrylamide gel electrophoresis and then transferred electrophoretically onto a nitrocellulose sheet; finally, the transferrin types on the nitrocellulose sheet are specifically detected by an antibody reaction. 1,5,9-cyclododecatriene 21-24 transferrin Homo sapiens 274-285 35060066-3 2022 We evaluated the ratio of carbohydrate-deficient transferrin to total transferrin (%CDT) in patients with fatty liver disease, particularly focusing on its correlation with metabolic factors (UMIN000033550). 1,5,9-cyclododecatriene 84-87 transferrin Homo sapiens 70-81 3044178-1 1988 Elevated concentrations of carbohydrate-deficient components of transferrin (CDT) in serum may be used as a sensitive and specific marker of regular, high alcohol consumption. 1,5,9-cyclododecatriene 77-80 transferrin Homo sapiens 64-75 33177062-6 2021 In vitro, linking doxorubicin (Dox) and transferrin (TF) to CND (CND-Dox-TF, CDT) was 10-100 times more potent than Dox against DLBCL cell lines. 1,5,9-cyclododecatriene 77-80 transferrin Homo sapiens 40-51