PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18159214-2	2008	In 30% of patients, the differentially methylated IGF2/H19 imprinting center region (ICR1) on chromosome 11p15 was found to be hypomethylated, as determined by Southern blot analysis of an HpaII restriction site close to the third CTCF-binding site (CTS3) within ICR1.	ctcf	231-235	insulin like growth factor 2	Homo sapiens	50-54	
19338988-9	2010	Hypomethylation also affected the CTCF-binding site 6, involved in regulation of IGF2 expression.	ctcf	34-38	insulin like growth factor 2	Homo sapiens	81-85	
19513555-0	2009	Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia.	ctcf	41-45	insulin like growth factor 2	Homo sapiens	68-72	
22427002-7	2012	Hypomethylation of the sixth CTCF-binding site in the DMR of IGF2/H19 is linked to LOI and the common IGF2-H19 enhancer competition model for IGF2 imprinting does not apply to human CRC.	ctcf	29-33	insulin like growth factor 2	Homo sapiens	61-65	
22427002-7	2012	Hypomethylation of the sixth CTCF-binding site in the DMR of IGF2/H19 is linked to LOI and the common IGF2-H19 enhancer competition model for IGF2 imprinting does not apply to human CRC.	ctcf	29-33	insulin like growth factor 2	Homo sapiens	102-106	
22427002-7	2012	Hypomethylation of the sixth CTCF-binding site in the DMR of IGF2/H19 is linked to LOI and the common IGF2-H19 enhancer competition model for IGF2 imprinting does not apply to human CRC.	ctcf	29-33	insulin like growth factor 2	Homo sapiens	102-106	
12588801-0	2003	Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site.	ctcf	105-109	insulin like growth factor 2	Homo sapiens	22-26	
18178607-11	2008	Additionally, unmethylation of the CTCF-binding site could lead to inactivation of the paternal IGF2 gene, and be linked to decreased embryo quality and birth weight, often associated with ART.	ctcf	35-39	insulin like growth factor 2	Homo sapiens	96-100	
12588801-5	2003	Bisulfite sequencing reveals IGF2 LOI occurs with biallelic CpG methylation of the CTCF-binding site, while H19 LOI occurs with biallelic hypomethylation of this site.	ctcf	83-87	insulin like growth factor 2	Homo sapiens	29-33	
12588801-6	2003	Our data demonstrate that IGF2 LOI and H19 LOI are accompanied by reciprocal methylation changes at a critical CTCF-binding site.	ctcf	111-115	insulin like growth factor 2	Homo sapiens	26-30	
11120891-3	2001	LOI of IGF2 correlated strongly with biallelic hypermethylation of a core of five CpG sites in the insulator region of IGF2/H19, which is a known CTCF-binding element.	ctcf	146-150	insulin like growth factor 2	Homo sapiens	7-11	
11120891-3	2001	LOI of IGF2 correlated strongly with biallelic hypermethylation of a core of five CpG sites in the insulator region of IGF2/H19, which is a known CTCF-binding element.	ctcf	146-150	insulin like growth factor 2	Homo sapiens	119-123