PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18548238-2	2008	We have demonstrated the relevance of CYP2C9 genotypes for diclofenac 4"-hydroxylation in healthy volunteers, so that the present study was aimed at analyzing the role of both CYP2C8 and CYP2C9 genotypes on diclofenac metabolism, as well as determining the CYP2C8 allele frequencies and their relationship with CYP2C9 variants.	diclofenac 4"	59-72	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	38-44	
24517573-1	2015	Cytochrome P450 2C9 (CYP2C9), one of the most important phase I drug metabolizing enzymes, could catalyze the reactions that convert diclofenanc into diclofenac 4"-hydroxylation.	diclofenac 4"	150-163	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-19	
24517573-1	2015	Cytochrome P450 2C9 (CYP2C9), one of the most important phase I drug metabolizing enzymes, could catalyze the reactions that convert diclofenanc into diclofenac 4"-hydroxylation.	diclofenac 4"	150-163	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	21-27	
21964418-4	2011	Although all of the oxidation reactions tested were more or less inhibited by PFOS, diclofenac 4"-hydroxylation mediated mainly by CYP2C9 was most strongly inhibited (K(i) value of 40 nM), followed by paclitaxel 6alpha-hydroxylation mediated mainly by CYP2C8 (K(i) value of 4 muM).	diclofenac 4"	84-97	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	131-137	
16719380-0	2006	Determination of CYP2C9-catalyzed diclofenac 4"-hydroxylation by high-performance liquid chromatography.	diclofenac 4"	34-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	17-23	
15618748-8	2003	ABT exhibited the highest Ki value for CYP2C9-dependent diclofenac 4"-hydroxylation among those determined by this assay (Ki=3500 microM).	diclofenac 4"	56-69	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	39-45	
15608129-9	2005	This assay thus represents a high-throughput version of the classic diclofenac 4"-hydroxylation assay, which is one of the most widely used methods to assess the potential for CYP2C9 inhibition of new chemical entities.	diclofenac 4"	68-81	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	176-182	
11853173-3	2002	Additionally, nonylphenol competitively inhibited diclofenac 4"-hydroxylation by CYP2C9 and S-mephenytoin 4"-hydroxylation by CYP2C19 with Ki values of 5.3 and 37 microM, respectively.	diclofenac 4"	50-63	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	81-87	
14577221-0	1998	Determination of CYP2C9-catalyzed diclofenac 4"-hydroxylation by high-performance liquid chromatography.	diclofenac 4"	34-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	17-23