PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12522090-5	2003	4 Magnolol treatment resulted in accumulation of cytosolic cytochrome c and activation of caspase-9 and downstream caspases (caspase-3 and -6).	magnolol	2-10	caspase 9	Homo sapiens	90-99	
12634615-4	2003	Activation of caspase-9, -3 and -2, and the proteolytic cleavage of poly(ADP-ribose) polymerase were found during apoptosis induced by magnolol.	magnolol	135-143	caspase 9	Homo sapiens	14-34	
12634615-5	2003	In addition, both pan-caspase and selective caspase-9 inhibitor blocked magnolol-induced apoptosis.	magnolol	72-80	caspase 9	Homo sapiens	44-53	
12634615-8	2003	In conclusion, our findings indicate that magnolol-induced apoptotic signaling is carried out through mitochondria alternations to caspase-9 and that then the downstream effector caspases are activated sequentially.	magnolol	42-50	caspase 9	Homo sapiens	131-140	
12522090-9	2003	6 These results indicate that regulation of the Bcl-2 family, accumulation of cytosolic cytochrome c, and activation of caspase-9 and caspase-3 may be the effector mechanisms of magnolol-induced apoptosis.	magnolol	178-186	caspase 9	Homo sapiens	120-129	
19655415-5	2009	Magnolol also inhibited H2O2-induced expressions of caspase-9 and caspase-3 and reduction of Bcl-2/Bax ratio.	magnolol	0-8	caspase 9	Homo sapiens	52-61	
31714653-9	2020	Most important, major extrinsic and intrinsic apoptosis signaling factors, including active caspase-8 and caspase-9 were both enhanced by magnolol.	magnolol	138-146	caspase 9	Homo sapiens	106-115	
17390340-11	2007	These results show that magnolol initiates apoptosis via the cytochrome-c/caspase 3/PARP/AIF and PTEN/Akt/caspase 9/PARP pathways and necrosis via PARP activation.	magnolol	24-32	caspase 9	Homo sapiens	106-115	
17390340-7	2007	Inhibition of either PARP or caspase activity blocked magnolol-induced apoptosis, supporting the involvement of the caspases and PARP.	magnolol	54-62	caspase 9	Homo sapiens	29-36	
17390340-7	2007	Inhibition of either PARP or caspase activity blocked magnolol-induced apoptosis, supporting the involvement of the caspases and PARP.	magnolol	54-62	caspase 9	Homo sapiens	116-124	
17390340-9	2007	These data suggest that magnolol promoted apoptosis probably by alleviating the inhibitory effect of Akt on caspase 9.	magnolol	24-32	caspase 9	Homo sapiens	108-117