PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20472713-12	2010	Xenon caused an increased expression of p-Akt, HIF-1alpha and Bcl-2, while the other noble gases did not modify protein expression.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57	
19144758-3	2009	Xenon increased the efficiency of HIF-1alpha translation via modulation of the mammalian target of rapamycin pathway.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44	
19144758-4	2009	In a model of renal ischemia-reperfusion injury, xenon provided morphologic and functional renoprotection; hydrodynamic injection of HIF-1alpha small interfering RNA demonstrated that this protection is HIF-1alpha dependent.	Xenon	49-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	203-213	
19144758-5	2009	These results suggest that xenon preconditioning is a natural inducer of HIF-1alpha and that administration of xenon before renal ischemia can prevent acute renal failure.	Xenon	27-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83	
19244689-4	2009	It was shown that pharmacological activation of the hypoxia-inducible factor 1alpha pathway is organ protective, and recent studies demonstrated that isoflurane and xenon lead to hypoxia-inducible factor 1alpha upregulation, which is related to the preconditioning effect of the inhalational anaesthetics.	Xenon	165-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-83	
19244689-4	2009	It was shown that pharmacological activation of the hypoxia-inducible factor 1alpha pathway is organ protective, and recent studies demonstrated that isoflurane and xenon lead to hypoxia-inducible factor 1alpha upregulation, which is related to the preconditioning effect of the inhalational anaesthetics.	Xenon	165-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-210	
25856291-8	2015	Xenon treatment enhanced HIF-1alpha, which attenuated HMGB-1 translocation and NF-kappaB activation in A549 cells with oxidative and inflammatory stress.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35	
25856291-9	2015	Xenon treatment enhanced p-mTOR, HIF-1alpha, and Bcl-2 expression and, in turn, promoted cell proliferation in the lung.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43	
25856291-11	2015	CONCLUSION: Xenon treatment confers protection against distant lung injury triggered by renal graft IRI, which is likely through the activation of mTOR-HIF-1alpha pathway and suppression of the HMGB-1 translocation from nuclei to cytoplasm.	Xenon	12-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162	
26939898-2	2016	Xenon is supposed to trigger the production of hypoxia-inducible factor 1alpha (HIF-1alpha) and subsequently erythropoietin, but data are limited to in vivo experimental work.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-78	
26939898-2	2016	Xenon is supposed to trigger the production of hypoxia-inducible factor 1alpha (HIF-1alpha) and subsequently erythropoietin, but data are limited to in vivo experimental work.	Xenon	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90	
24861600-2	2014	Since the production of the hypoxia-inducible factor 1alpha (HIF-1alpha) and its downstream effector erythropoietin as well as noradrenalin reuptake inhibition have been found to play key roles in this context, the question arose as to whether the use of xenon is a matter for doping controls and preventive doping research.	Xenon	255-260	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-59	
24861600-2	2014	Since the production of the hypoxia-inducible factor 1alpha (HIF-1alpha) and its downstream effector erythropoietin as well as noradrenalin reuptake inhibition have been found to play key roles in this context, the question arose as to whether the use of xenon is a matter for doping controls and preventive doping research.	Xenon	255-260	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71