PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21041628-3 2010 We found that dietary sulindac induced apoptosis to remove the intestinal stem cells with nuclear or phosphorylated beta-catenin in APC(Min/+) mice. Sulindac 22-30 catenin (cadherin associated protein), beta 1 Mus musculus 116-128 21403839-0 2011 Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis. Sulindac 41-49 catenin (cadherin associated protein), beta 1 Mus musculus 15-27 21403839-4 2011 We treated colon cancer cell lines heterozygous for gain-of-function and wild-type beta-catenin with sulindac. Sulindac 101-109 catenin (cadherin associated protein), beta 1 Mus musculus 83-95 21403839-8 2011 We report the expression knockdown of beta-catenin by sulindac, leading to its reduced nuclear accumulation. Sulindac 54-62 catenin (cadherin associated protein), beta 1 Mus musculus 38-50 21403839-12 2011 Splenic tumors and liver metastases of sulindac-treated mice showed lowered beta-catenin and S100A4 levels. Sulindac 39-47 catenin (cadherin associated protein), beta 1 Mus musculus 76-88 21403839-13 2011 These results suggest that modulators of beta-catenin signaling such as sulindac offer potential as antimetastatic agents by interdicting S100A4 expression. Sulindac 72-80 catenin (cadherin associated protein), beta 1 Mus musculus 41-53 23327547-4 2013 Mechanistic studies revealed that the combination of selenium and sulindac led to the significant induction of the expression of p27 and p53 and JNK1 phosphorylation, and led to the suppression of beta-catenin and its downstream targets. Sulindac 66-74 catenin (cadherin associated protein), beta 1 Mus musculus 197-209 21041628-5 2010 Furthermore, deficiency in SMAC, a mitochondrial apoptogenic protein, attenuated the tumor-suppressive effect of sulindac in APC(Min/+) mice by blocking apoptosis and removal of stem cells with nuclear or phosphorylated beta-catenin. Sulindac 113-121 catenin (cadherin associated protein), beta 1 Mus musculus 220-232 12584176-0 2003 Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Sulindac 123-131 catenin (cadherin associated protein), beta 1 Mus musculus 71-83 20716632-8 2010 Sulindac is also known to exert its growth inhibitory effects through regulation of many noncyclooxygenase targets, including p21, beta-catenin, E-cadherin, mitochondrial apoptotic proteins, and peroxisome proliferator-activated receptor-gamma. Sulindac 0-8 catenin (cadherin associated protein), beta 1 Mus musculus 131-143 20716632-9 2010 We found that sulindac treatment protected against E-cadherin loss in colon tumors, with associated inhibition of nuclear beta-catenin accumulation. Sulindac 14-22 catenin (cadherin associated protein), beta 1 Mus musculus 122-134 12584176-12 2003 beta-catenin and beta-catenin/Tcf-4 regulated proteins Cyclin D(1) and c-Jun were readily detected in polyps, but markedly reduced in normal-looking intestines of mice treated with both tea and sulindac. Sulindac 194-202 catenin (cadherin associated protein), beta 1 Mus musculus 0-12 12584176-12 2003 beta-catenin and beta-catenin/Tcf-4 regulated proteins Cyclin D(1) and c-Jun were readily detected in polyps, but markedly reduced in normal-looking intestines of mice treated with both tea and sulindac. Sulindac 194-202 catenin (cadherin associated protein), beta 1 Mus musculus 17-29 12584176-13 2003 This research provides evidence that teas, particularly when administered in combination with sulindac, are highly effective at inhibiting intestinal neoplasia in male Apc(min) mice via direct or indirect effects on the beta-catenin/APC pathway. Sulindac 94-102 catenin (cadherin associated protein), beta 1 Mus musculus 220-232 12351151-7 2002 In the normal-looking intestinal mucosa of Apc(min) and A 33(delta N beta-cat) mice, white tea plus sulindac treatment markedly attenuated the expression of beta-catenin protein, and this was recapitulated in vitro in cells transiently transfected with beta-catenin plus Tcf-4 and treated with tea or the major tea polyphenol epigallocatechin-3-gallate (EGCG). Sulindac 100-108 catenin (cadherin associated protein), beta 1 Mus musculus 157-169 12351151-7 2002 In the normal-looking intestinal mucosa of Apc(min) and A 33(delta N beta-cat) mice, white tea plus sulindac treatment markedly attenuated the expression of beta-catenin protein, and this was recapitulated in vitro in cells transiently transfected with beta-catenin plus Tcf-4 and treated with tea or the major tea polyphenol epigallocatechin-3-gallate (EGCG). Sulindac 100-108 catenin (cadherin associated protein), beta 1 Mus musculus 253-265 12351151-8 2002 Expression of a beta-catenin/Tcf reporter was inhibited by EGCG in the transfected cells, and the beta-catenin/Tcf target genes cyclin D1 and c-jun were downregulated in vivo by tea plus sulindac treatment. Sulindac 187-195 catenin (cadherin associated protein), beta 1 Mus musculus 16-28 12351151-8 2002 Expression of a beta-catenin/Tcf reporter was inhibited by EGCG in the transfected cells, and the beta-catenin/Tcf target genes cyclin D1 and c-jun were downregulated in vivo by tea plus sulindac treatment. Sulindac 187-195 catenin (cadherin associated protein), beta 1 Mus musculus 98-110 12351151-9 2002 Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway. Sulindac 66-74 catenin (cadherin associated protein), beta 1 Mus musculus 148-160 11245490-20 2001 Polyps from either rofecoxib- or sulindac-treated mice had lower rates of DNA replication, expressed less proangiogenic vascular endothelial-derived growth factor and more membrane-bound beta-catenin, but showed unchanged nuclear localization of this transcription factor. Sulindac 33-41 catenin (cadherin associated protein), beta 1 Mus musculus 187-199 29434827-9 2018 Mechanistically, SUL and CLX suppressed the expression of the Apc target genes beta-catenin, cyclin D1, c-Myc and cyclooxygenase-2. Sulindac 17-20 catenin (cadherin associated protein), beta 1 Mus musculus 79-91 10223192-0 1999 Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. Sulindac 53-61 catenin (cadherin associated protein), beta 1 Mus musculus 16-28