PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10224662-2	1999	7-Ketocholesterol can inhibit cholesterol 7 alpha-hydroxylase, the rate-limiting step in bile acid biosynthesis, as well as strongly inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.	7-ketocholesterol	0-17	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	30-61	
24771866-1	2014	A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.	7-ketocholesterol	33-50	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	84-109	
9632680-11	1998	Since 7-oxocholesterol is a potent inhibitor of cholesterol 7alpha-hydroxylase, alternative mechanisms for regulation of bile acid synthesis may exist in human and hamster liver due to production of this metabolite and its potential as an oxysterol.	7-ketocholesterol	6-22	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	48-78	
24771866-1	2014	A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.	7-ketocholesterol	160-177	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	84-109	
24771866-7	2014	Downregulation of CYP7A1 activity by treatment with chenodeoxycholic acid reduced the levels of 7-ketocholesterol in parallel with decreased levels of 7-dehydrocholesterol and cholesterol-7,8-epoxide.	7-ketocholesterol	96-113	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	18-24	
21813643-0	2011	Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.	7-ketocholesterol	38-55	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	78-97