PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11521968-0 2001 Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. 7-ketocholesterol 28-45 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 50-71 24771866-0 2014 On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. 7-ketocholesterol 20-37 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 81-84 24771866-5 2014 In accord with this hypothesis, two patients with CTX were found to have increased levels of 7-ketocholesterol and 7-dehydrocholesterol, as well as a significant level of cholesterol-7,8-epoxide. 7-ketocholesterol 93-110 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 50-53 21411718-0 2011 Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. 7-ketocholesterol 14-31 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 72-79 17495602-5 2007 Both CYP27A1 and CYP46A1 are expressed in primate retina indicating that local metabolism of 7-ketocholesterol to nontoxic derivatives is important for preventing retinal degeneration. 7-ketocholesterol 93-110 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 5-12 10869358-0 2000 Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. 7-ketocholesterol 30-47 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 0-21 10869358-3 2000 We hypothesized and here show that 27-hydroxylated 7-ketocholesterol (270H-7K) is present in human lesions, probably generated by the action of sterol 27-hydroxylase on 7K. 7-ketocholesterol 51-68 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 144-165 21498512-2 2011 Mitochondrial cytochrome P450 27A1 (CYP27A1) is a ubiquitous multifunctional sterol C27-hydroxylase that eliminates cholesterol and likely 7-ketocholesterol from the retina and many other tissues. 7-ketocholesterol 139-156 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 14-34 21498512-2 2011 Mitochondrial cytochrome P450 27A1 (CYP27A1) is a ubiquitous multifunctional sterol C27-hydroxylase that eliminates cholesterol and likely 7-ketocholesterol from the retina and many other tissues. 7-ketocholesterol 139-156 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 36-43 16549062-1 2006 Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh). 7-ketocholesterol 123-140 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 0-21 16549062-1 2006 Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh). 7-ketocholesterol 123-140 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 23-30