PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33409276-4 2020 In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta. 7-ketocholesterol 98-115 interleukin 1 alpha Mus musculus 296-304 33409276-4 2020 In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta. 7-ketocholesterol 117-122 interleukin 1 alpha Mus musculus 296-304 33409276-6 2020 Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1beta-containing EVs in ECs. 7-ketocholesterol 89-94 interleukin 1 alpha Mus musculus 114-122 32771556-8 2020 The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion. 7-ketocholesterol 53-84 interleukin 1 alpha Mus musculus 218-226