PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17151911-0	2007	Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers.	7-ketocholesterol	27-44	calmodulin 1	Rattus norvegicus	76-86	
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	7-ketocholesterol	59-76	calmodulin 1	Rattus norvegicus	0-10	
17151911-4	2007	Unlike cell injury, calmodulin antagonists, nicardipine, and BAPTA-AM prevented the 7-ketocholesterol-induced elevations of intracellular Ca2+ levels.	7-ketocholesterol	84-101	calmodulin 1	Rattus norvegicus	20-30	
17151911-5	2007	The results show that the cytotoxicity of 7-ketocholesterol seems to be modulated by calmodulin rather than changes in intracellular Ca2+ levels.	7-ketocholesterol	42-59	calmodulin 1	Rattus norvegicus	85-95	
17151911-6	2007	Calmodulin antagonists may prevent the cytotoxicity of 7-ketocholesterol by suppressing the mitochondrial permeability transition formation, which is associated with the increased formation of reactive oxygen species and the depletion of GSH.	7-ketocholesterol	55-72	calmodulin 1	Rattus norvegicus	0-10	
17224136-0	2007	Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition.	7-ketocholesterol	14-31	calmodulin 1	Rattus norvegicus	79-89	
17224136-2	2007	The present study investigated the effect of calmodulin antagonists (trifluoperazine, W-7 and calmidazolium) against the cytotoxicity of 7-ketocholesterol in relation to the mitochondria-mediated cell death process and oxidative stress.	7-ketocholesterol	137-154	calmodulin 1	Rattus norvegicus	45-55	
17224136-5	2007	Calmodulin antagonists attenuated the 7-ketocholesterol-induced nuclear damage, formation of the mitochondrial permeability transition and cell viability loss in PC12 cells.	7-ketocholesterol	38-55	calmodulin 1	Rattus norvegicus	0-10	
17224136-6	2007	The results suggest that calmodulin antagonists may prevent the 7-ketocholesterol-induced viability loss in PC12 cells by suppressing formation of the mitochondrial permeability transition, leading to the release of cytochrome c and subsequent activation of caspase-3.	7-ketocholesterol	64-81	calmodulin 1	Rattus norvegicus	25-35	
17224136-8	2007	The findings suggest that calmodulin inhibition may exhibit a protective effect against the neurotoxicity of 7-ketocholesterol.	7-ketocholesterol	109-126	calmodulin 1	Rattus norvegicus	26-36