PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17325185-0	2007	Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	0-9	
26122972-4	2015	7-Ketocholesterol and 25-hydroxycholesterol decreased the levels of Bid and Bcl-2, increased the levels of Bax and p53, and induced loss of the mitochondrial transmembrane potential, release of cytochrome c and activation of caspases (-8, -9 and -3).	7-ketocholesterol	0-17	caspase 8	Rattus norvegicus	225-248	
25845326-3	2015	7-Ketocholesterol and 25-hydroxycholesterol induced a decrease in the levels of BH3 interacting-domain death agonist (Bid) and B cell lymphoma 2 (Bcl-2), increase in the levels of Bcl-2-associated X protein (Bax) and p53, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases, and cleavage of poly(ADP-ribose) polymerase 1 (PARP-1).	7-ketocholesterol	0-17	caspase 8	Rattus norvegicus	309-317	
21035514-7	2011	Results from this study suggest that 7-ketocholesterol may exert an apoptotic effect against PC12 cells by inducing activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell death pathway, leading to activation of caspases, via the reactive oxygen species-dependent activation of NF-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	134-143	
21035514-7	2011	Results from this study suggest that 7-ketocholesterol may exert an apoptotic effect against PC12 cells by inducing activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell death pathway, leading to activation of caspases, via the reactive oxygen species-dependent activation of NF-kappaB, which is mediated by the Akt pathway.	7-ketocholesterol	37-54	caspase 8	Rattus norvegicus	258-266