PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2030746-2	1991	Therefore, we studied the effects of the calmodulin antagonists fendiline and calmidazolium on the thrombin-induced aggregation, secretion of ATP, and increases in the intracellular free calcium concentration ([Ca2+]i) in washed human platelets in the absence and presence of extracellular Ca2+.	Fendiline	64-73	coagulation factor II, thrombin	Homo sapiens	99-107	
2030746-4	1991	The effect of fendiline could be partly reversed by extracellular Ca2+ and higher thrombin concentrations.	Fendiline	14-23	coagulation factor II, thrombin	Homo sapiens	82-90	
2030746-5	1991	Furthermore, aggregations induced by the calcium ionophore ionomycin and by the protein kinase C-activator 4-beta-phorbol 12-myristate 13-acetate were inhibited by fendiline, although to a smaller degree than the thrombin-induced aggregation.	Fendiline	164-173	coagulation factor II, thrombin	Homo sapiens	213-221	
2030746-6	1991	Thrombin-induced secretion of ATP was attenuated by low concentrations of fendiline (1-3 microM) and calmidazolium (1 microM) but enhanced by higher concentrations (10-30 and 3-10 microM, respectively), independently of extracellular Ca2+.	Fendiline	74-83	coagulation factor II, thrombin	Homo sapiens	0-8