PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29710837-1 2018 The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. Adenosine Monophosphate 73-76 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-11 29710837-5 2018 Molecular dynamics (MD) simulations showed that V366M creates a “one-way valve” and suggests a mechanism for dual activities of human CYP17A1 where, after the conversion of pregnenolone to 17OH-pregnenolone, the product exits the active site and re-enters for conversion to dehydroepiandrosterone. Adenosine Monophosphate 65-68 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 154-161 29710837-5 2018 Molecular dynamics (MD) simulations showed that V366M creates a “one-way valve” and suggests a mechanism for dual activities of human CYP17A1 where, after the conversion of pregnenolone to 17OH-pregnenolone, the product exits the active site and re-enters for conversion to dehydroepiandrosterone. Adenosine Monophosphate 89-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 154-161