PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6294007-4 1982 In the presence of AMP-S (an AMP analogue inhibiting 5"-nucleotidase, as shown biochemically) there was a decrease in both the number of positive macrophages and the amount of reaction product on the plasma membranes. Adenosine Monophosphate 19-22 5' nucleotidase, ecto Mus musculus 53-68 8350982-9 1993 Our results suggest that ecto-5"-nucleotidase may play a crucial role in the hydrolysis of AMP to adenosine at the mossy fibre synapses. Adenosine Monophosphate 91-94 5' nucleotidase, ecto Mus musculus 25-45 34502315-1 2021 Cluster of differentiation 73 (CD73, also known as ecto-5"-nucleotidase) is an enzyme that converts AMP into adenosine. Adenosine Monophosphate 100-103 5' nucleotidase, ecto Mus musculus 51-71 34905223-11 2022 Similarly, inhibition of NTPDase 1 and 3, NPP1 and eN induced stronger, rather than weaker, presynaptic inhibition, both in endogenous condition and with bath-applied ATP and AMP. Adenosine Monophosphate 175-178 5' nucleotidase, ecto Mus musculus 51-53 2984303-3 1985 The inhibition of lysosomal enzyme secretion by ATP, ADP, and AMP was reversed by adding alpha, beta -methylene ADP (100 microM), a 5"-nucleotidase inhibitor, to the incubation medium. Adenosine Monophosphate 62-65 5' nucleotidase, ecto Mus musculus 132-147 6298508-4 1982 The activity of membrane-bound 5"-nucleotidase, that is, AMP-hydrolyzing activity inhibited by 100 microM alpha, beta-methyleneadenosine 5"-diphosphate, progressively increased as a function of age, indicating thymocyte population changes occurring very late in life. Adenosine Monophosphate 57-60 5' nucleotidase, ecto Mus musculus 31-46 6285971-3 1982 Furthermore the hydrolysis of AMP by the membrane was unaffected by the 5"-nucleotidase inhibitor alpha, beta-methyleneadenosine diphosphate and by the lectin concanavalin A, another potent inhibitor of 5"-nucleotidase. Adenosine Monophosphate 30-33 5' nucleotidase, ecto Mus musculus 203-218 6285971-5 1982 These results suggest that the hydrolysis of AMP by porcine polymorph membranes is not accomplished by a specific 5"-nucleotidase and the necessity for distinguishing between true 5"-nucleotidase and non-specific phosphatase activity is discussed. Adenosine Monophosphate 45-48 5' nucleotidase, ecto Mus musculus 180-195 2984303-4 1985 Inhibition by adenosine, however, was unaffected by alpha, beta -methylene ADP indicating that the inhibition by AMP, ADP, and ATP only occurred after they had been converted to adenosine by cell surface phosphohydrolases, including 5"-nucleotidase. Adenosine Monophosphate 113-116 5' nucleotidase, ecto Mus musculus 233-248 33683190-5 2021 CD39 and CD73, expressed on the surface of Tregs, hydrolyze ATP to AMP and are further involved in the immunosuppressive function of Tregs. Adenosine Monophosphate 67-70 5' nucleotidase, ecto Mus musculus 9-13 42219-4 1979 In all the experiments activity of 5"-nucleotidase was lower towards CMP as compared with AMP. Adenosine Monophosphate 90-93 5' nucleotidase, ecto Mus musculus 35-50 1003105-2 1976 Mouse resident peritoneal macrophages display sufficient 5"-nucleotidase activity to hydrolyze 58 nm AMP/min per cell protein. Adenosine Monophosphate 101-104 5' nucleotidase, ecto Mus musculus 57-72 33516905-3 2021 CD73 is the major enzyme that dephosphorylates extracellular adenosine monophosphate (AMP) to form the anti-inflammatory adenosine. Adenosine Monophosphate 86-89 5' nucleotidase, ecto Mus musculus 0-4 33516905-13 2021 There was significant hypo-phosphorylation of AMPK substrates in CD73-LKO livers (p<0.0001), while in isolated hepatocytes treated with AMP, soluble CD73 induced AMPK activation (p<0.001). Adenosine Monophosphate 46-49 5' nucleotidase, ecto Mus musculus 65-69 33516905-13 2021 There was significant hypo-phosphorylation of AMPK substrates in CD73-LKO livers (p<0.0001), while in isolated hepatocytes treated with AMP, soluble CD73 induced AMPK activation (p<0.001). Adenosine Monophosphate 46-49 5' nucleotidase, ecto Mus musculus 149-153 149137-3 1978 Addition of adenosine monophosphate to the culture medium led to an augmented (5-fold) increase in the specific activity (per unit cell protein) as well as an absolute increase (per culture plate) of 5"-nucleotidase. Adenosine Monophosphate 12-35 5' nucleotidase, ecto Mus musculus 200-215 32999463-5 2020 ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is expressed on microglia as well as other brain cells. Adenosine Monophosphate 131-134 5' nucleotidase, ecto Mus musculus 176-180 32999463-5 2020 ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is expressed on microglia as well as other brain cells. Adenosine Monophosphate 136-139 5' nucleotidase, ecto Mus musculus 176-180 30249343-8 2019 While the increased expression of A2AR-allows activated gammadelta T cells to bind adenosine more effectively than other immune cells, the decreased CD73 restricts their ability to convert AMP to adenosine. Adenosine Monophosphate 189-192 5' nucleotidase, ecto Mus musculus 149-153 31619062-1 2020 OBJECTIVE: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine Monophosphate 73-76 5' nucleotidase, ecto Mus musculus 11-15 31191254-1 2019 CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. Adenosine Monophosphate 125-128 5' nucleotidase, ecto Mus musculus 0-4 31191254-6 2019 The results indicated that the addition of exogenous AMP significantly inhibited cytokine/chemokine production by wild type astrocytes but had no effect on CD73-/- astrocytes and that the effect of AMP was almost completely blocked by the addition of either a CD73 inhibitor (APCP) or an adenosine receptor A1 subtype (ARA1) antagonist (DPCPX). Adenosine Monophosphate 53-56 5' nucleotidase, ecto Mus musculus 260-264 29788960-3 2018 Ecto-5"-nucleotidase (CD73) is an immunosuppressive molecule intricately involved in adaptive and innate immune responses and is able to dephosphorylate AMP to adenosine. Adenosine Monophosphate 153-156 5' nucleotidase, ecto Mus musculus 0-20 29725032-4 2018 Furthermore, after its release into the extracellular space, ATP is processed by ectonucleotidases: CD39 converts ATP to AMP, and CD73 converts AMP to adenosine. Adenosine Monophosphate 144-147 5' nucleotidase, ecto Mus musculus 130-134 29332180-2 2018 Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5"-nucleotidase. Adenosine Monophosphate 56-59 5' nucleotidase, ecto Mus musculus 161-165 29332180-2 2018 Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5"-nucleotidase. Adenosine Monophosphate 119-122 5' nucleotidase, ecto Mus musculus 161-165 29332180-2 2018 Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5"-nucleotidase. Adenosine Monophosphate 119-122 5' nucleotidase, ecto Mus musculus 170-190 29788960-3 2018 Ecto-5"-nucleotidase (CD73) is an immunosuppressive molecule intricately involved in adaptive and innate immune responses and is able to dephosphorylate AMP to adenosine. Adenosine Monophosphate 153-156 5' nucleotidase, ecto Mus musculus 22-26 28772215-5 2017 These results demonstrated an increase (p<0.05) in NTPDase (adenosine triphosphate (ATP substrate) or adenosine diphosphate (ADP substrate)), 5"-nucleotidase (AMP substrate) and adenosine deaminase (ADA; adenosine substrate) activities in serum from the group DW compared to the group CW. Adenosine Monophosphate 162-165 5' nucleotidase, ecto Mus musculus 145-160 30221577-2 2018 S. suis 5"-nucleotidase is able to convert adenosine monophosphate to adenosine, resulting in inhibiting neutrophil functions in vitro and it is an important virulence factor. Adenosine Monophosphate 43-66 5' nucleotidase, ecto Mus musculus 8-23 28507174-6 2017 Genetic deletion of CD73 (an ectonucleotidase that converts AMP to adenosine) prevented the elevation of placental adenosine in the autoantibody-induced preeclampsia mouse model and ameliorated preeclampsia features and placental DNA hypomethylation. Adenosine Monophosphate 60-63 5' nucleotidase, ecto Mus musculus 20-24 28746349-4 2017 Here we further investigate how these Ampd3-/-/Cd73-/- mice respond to the administered dose of AMP in comparison with the control models of single enzyme deficiency and wild type. Adenosine Monophosphate 96-99 5' nucleotidase, ecto Mus musculus 47-51 28746349-5 2017 We found that Ampd3-/-/Cd73-/- mice are more sensitive to AMP-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type. Adenosine Monophosphate 58-61 5' nucleotidase, ecto Mus musculus 23-27 28432149-18 2017 The underlying mechanism involves a profound increase in the hydrolysis of ATP/NAD and AMP, resulting primarily from the upregulation of pyrophosphatases and CD73. Adenosine Monophosphate 87-90 5' nucleotidase, ecto Mus musculus 158-162 28038380-1 2017 BACKGROUND AND AIMS: Mutations in the 5"-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. Adenosine Monophosphate 119-122 5' nucleotidase, ecto Mus musculus 38-58 28192180-10 2017 AMP hydrolysis in CD73-/- was below 10% of WT. Adenosine Monophosphate 0-3 5' nucleotidase, ecto Mus musculus 18-22 28038380-1 2017 BACKGROUND AND AIMS: Mutations in the 5"-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. Adenosine Monophosphate 119-122 5' nucleotidase, ecto Mus musculus 60-64 28038380-1 2017 BACKGROUND AND AIMS: Mutations in the 5"-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. Adenosine Monophosphate 119-122 5' nucleotidase, ecto Mus musculus 84-88 26964090-1 2016 CD73 (ecto-5"-nucleotidase), a cell surface enzyme hydrolyzing AMP to adenosine, was lately demonstrated to play a direct role in tumor progression including regulation of tumor vascularization. Adenosine Monophosphate 63-66 5' nucleotidase, ecto Mus musculus 0-4 27417582-3 2016 CD73 hydrolyzes AMP to adenosine. Adenosine Monophosphate 16-19 5' nucleotidase, ecto Mus musculus 0-4 26964090-1 2016 CD73 (ecto-5"-nucleotidase), a cell surface enzyme hydrolyzing AMP to adenosine, was lately demonstrated to play a direct role in tumor progression including regulation of tumor vascularization. Adenosine Monophosphate 63-66 5' nucleotidase, ecto Mus musculus 6-26 26919582-2 2016 Given that CD73 is the main enzyme responsible for conversion of AMP into the immunosuppressive molecule adenosine, we investigated its role in the regulatory function of gammadelta T cells in experimental autoimmune uveitis (EAU). Adenosine Monophosphate 65-68 5' nucleotidase, ecto Mus musculus 11-15 24880143-11 2014 The robust inhibition of conventional T-cell proliferation was uniquely observed when CD73(+) RPE cells in the upper chamber were in the presence of AMP. Adenosine Monophosphate 149-152 5' nucleotidase, ecto Mus musculus 86-90 26432867-5 2015 Because AMP hydrolysis by the ecto-5"-nucleotidase (CD73) plays a central role in and is rate-limiting for generation of adenosine in the normal lung, we hypothesized that ALI would be attenuated in C57BL/6-congenic CD73-knockout (CD73-KO) mice. Adenosine Monophosphate 8-11 5' nucleotidase, ecto Mus musculus 30-50 26432867-5 2015 Because AMP hydrolysis by the ecto-5"-nucleotidase (CD73) plays a central role in and is rate-limiting for generation of adenosine in the normal lung, we hypothesized that ALI would be attenuated in C57BL/6-congenic CD73-knockout (CD73-KO) mice. Adenosine Monophosphate 8-11 5' nucleotidase, ecto Mus musculus 52-56 26432867-5 2015 Because AMP hydrolysis by the ecto-5"-nucleotidase (CD73) plays a central role in and is rate-limiting for generation of adenosine in the normal lung, we hypothesized that ALI would be attenuated in C57BL/6-congenic CD73-knockout (CD73-KO) mice. Adenosine Monophosphate 8-11 5' nucleotidase, ecto Mus musculus 216-220 26432867-5 2015 Because AMP hydrolysis by the ecto-5"-nucleotidase (CD73) plays a central role in and is rate-limiting for generation of adenosine in the normal lung, we hypothesized that ALI would be attenuated in C57BL/6-congenic CD73-knockout (CD73-KO) mice. Adenosine Monophosphate 8-11 5' nucleotidase, ecto Mus musculus 216-220 25805696-3 2015 Ecto-5"-nucleotidase (CD73), which dephosphorylates AMP to adenosine, is considered to catalyze the rate-limiting step in the generation of extracellular adenosine. Adenosine Monophosphate 52-55 5' nucleotidase, ecto Mus musculus 0-20 25805696-3 2015 Ecto-5"-nucleotidase (CD73), which dephosphorylates AMP to adenosine, is considered to catalyze the rate-limiting step in the generation of extracellular adenosine. Adenosine Monophosphate 52-55 5' nucleotidase, ecto Mus musculus 22-26 25681585-3 2015 AMP that accumulates during ischemia can be metabolized to adenosine by 5"-nucleotidase or to IMP by AMPD. Adenosine Monophosphate 0-3 5' nucleotidase, ecto Mus musculus 72-87 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 193-216 5' nucleotidase, ecto Mus musculus 70-90 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 193-216 5' nucleotidase, ecto Mus musculus 92-94 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 193-216 5' nucleotidase, ecto Mus musculus 110-114 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 218-221 5' nucleotidase, ecto Mus musculus 70-90 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 218-221 5' nucleotidase, ecto Mus musculus 92-94 25129451-2 2014 Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5"-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Adenosine Monophosphate 218-221 5' nucleotidase, ecto Mus musculus 110-114 24990899-2 2014 Because adenosine importantly regulates renovascular function, we investigated whether both TNAP and CD73 are involved in the renovascular metabolism of 5"-AMP. Adenosine Monophosphate 153-159 5' nucleotidase, ecto Mus musculus 101-105 24990899-6 2014 Levamisole per se did not inhibit renovascular 5"-AMP metabolism; however, in the presence of levamisole, 5"-AMP increased renal venous 5"-AMP threefold more in CD73-/- vs. CD73+/+ kidneys and knockout of CD73 inhibited 5"-induced adenosine and inosine by 81 and 86%, respectively. Adenosine Monophosphate 106-112 5' nucleotidase, ecto Mus musculus 161-165 24990899-6 2014 Levamisole per se did not inhibit renovascular 5"-AMP metabolism; however, in the presence of levamisole, 5"-AMP increased renal venous 5"-AMP threefold more in CD73-/- vs. CD73+/+ kidneys and knockout of CD73 inhibited 5"-induced adenosine and inosine by 81 and 86%, respectively. Adenosine Monophosphate 106-112 5' nucleotidase, ecto Mus musculus 161-165 24990899-8 2014 In conclusion, CD73 and TNAP play interactive roles to metabolize luminally applied 5"-AMP in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine. Adenosine Monophosphate 84-90 5' nucleotidase, ecto Mus musculus 15-19 26331349-1 2015 The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Adenosine Monophosphate 54-57 5' nucleotidase, ecto Mus musculus 4-8 26258883-1 2015 The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. Adenosine Monophosphate 48-51 5' nucleotidase, ecto Mus musculus 15-19 25465225-3 2014 Therefore the aim of this study was to clarify the role of host CD73, which catalyzes the extracellular hydrolysis of AMP to adenosine, on tumor growth and metastasis of B16-F10 melanoma cells. Adenosine Monophosphate 118-121 5' nucleotidase, ecto Mus musculus 64-68 25268760-5 2014 Exogenous AMP had a significant inhibitory effect on autoreactive T cell responses, but only in the presence of CD73+ gammadelta T cells, and this effect was abolished by a CD73 inhibitor. Adenosine Monophosphate 10-13 5' nucleotidase, ecto Mus musculus 112-116 25268760-5 2014 Exogenous AMP had a significant inhibitory effect on autoreactive T cell responses, but only in the presence of CD73+ gammadelta T cells, and this effect was abolished by a CD73 inhibitor. Adenosine Monophosphate 10-13 5' nucleotidase, ecto Mus musculus 173-177 24990899-0 2014 Interactive roles of CD73 and tissue nonspecific alkaline phosphatase in the renal vascular metabolism of 5"-AMP. Adenosine Monophosphate 106-112 5' nucleotidase, ecto Mus musculus 21-25 24990899-1 2014 CD73 metabolizes extracellular 5"-AMP to adenosine; yet recent experiments in brain tissue suggest that CD73 is not required for the metabolism of 5"-AMP to adenosine because of tissue nonspecific alkaline phosphatase (TNAP), which like CD73 is a GPI-anchored ecto-enyzme with 5"-nucleotidase activity. Adenosine Monophosphate 31-37 5' nucleotidase, ecto Mus musculus 0-4 23776700-1 2013 CD73 (ecto-5"-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. Adenosine Monophosphate 126-129 5' nucleotidase, ecto Mus musculus 0-4 23983257-3 2013 EXPERIMENTAL DESIGN: In this study, we investigated whether targeted blockade of CD73, an ectonucleotidase that catabolizes the hydrolysis of extracellular adenosine monophosphate (AMP) to adenosine, can enhance the antitumor activity of anti-CTLA-4 and anti-PD-1 mAbs against transplanted and chemically induced mouse tumors. Adenosine Monophosphate 156-179 5' nucleotidase, ecto Mus musculus 81-85 23983257-3 2013 EXPERIMENTAL DESIGN: In this study, we investigated whether targeted blockade of CD73, an ectonucleotidase that catabolizes the hydrolysis of extracellular adenosine monophosphate (AMP) to adenosine, can enhance the antitumor activity of anti-CTLA-4 and anti-PD-1 mAbs against transplanted and chemically induced mouse tumors. Adenosine Monophosphate 181-184 5' nucleotidase, ecto Mus musculus 81-85 24066228-5 2013 Measurements of renal venous adenosine and inosine (adenosine metabolite) by liquid chromatography-tandem mass spectrometry demonstrated that the metabolism of exogenous 5"-AMP to adenosine and inosine was similar in CD73 -/- versus CD73 +/+ kidneys. Adenosine Monophosphate 170-176 5' nucleotidase, ecto Mus musculus 217-221 24066228-5 2013 Measurements of renal venous adenosine and inosine (adenosine metabolite) by liquid chromatography-tandem mass spectrometry demonstrated that the metabolism of exogenous 5"-AMP to adenosine and inosine was similar in CD73 -/- versus CD73 +/+ kidneys. Adenosine Monophosphate 170-176 5' nucleotidase, ecto Mus musculus 233-237 23843511-3 2013 We now show that ecto-5"-nucleotidase (CD73), the major enzyme able to convert extracellular AMP into adenosine, colocalizes with A2ARs in the basal ganglia. Adenosine Monophosphate 93-96 5' nucleotidase, ecto Mus musculus 17-37 23843511-3 2013 We now show that ecto-5"-nucleotidase (CD73), the major enzyme able to convert extracellular AMP into adenosine, colocalizes with A2ARs in the basal ganglia. Adenosine Monophosphate 93-96 5' nucleotidase, ecto Mus musculus 39-43 23825434-8 2013 Last, we found that AMP inhibited excitatory neurotransmission via adenosine A1 receptor activation in spinal cord slices from wild-type, Pap-/-, Nt5e-/-, and dKO mice, but failed to inhibit neurotransmission in slices from dKO mice treated with MLS-0038949. Adenosine Monophosphate 20-23 5' nucleotidase, ecto Mus musculus 146-150 23825434-9 2013 These data suggest that triple elimination of TNAP, PAP, and NT5E is required to block AMP hydrolysis to adenosine in DRG neurons and dorsal spinal cord. Adenosine Monophosphate 87-90 5' nucleotidase, ecto Mus musculus 61-65 24668173-6 2014 A nucleotidase inhibitor and A2a adenosine receptor antagonist inhibited the apoptotic supernatant-induced gene expression, suggesting AMP was metabolized to adenosine by an ecto-5"-nucleotidase expressed on macrophages, to activate the macrophage A2a adenosine receptor. Adenosine Monophosphate 135-138 5' nucleotidase, ecto Mus musculus 174-194 25486201-2 2014 This disease is caused by mutations in the NT5E gene which encodes CD73, a membrane-bound ecto-5"-nucleotidase hydrolyzing 5"-AMP into adenosine and Pi. Adenosine Monophosphate 123-129 5' nucleotidase, ecto Mus musculus 43-47 25486201-2 2014 This disease is caused by mutations in the NT5E gene which encodes CD73, a membrane-bound ecto-5"-nucleotidase hydrolyzing 5"-AMP into adenosine and Pi. Adenosine Monophosphate 123-129 5' nucleotidase, ecto Mus musculus 67-71 25486201-2 2014 This disease is caused by mutations in the NT5E gene which encodes CD73, a membrane-bound ecto-5"-nucleotidase hydrolyzing 5"-AMP into adenosine and Pi. Adenosine Monophosphate 123-129 5' nucleotidase, ecto Mus musculus 90-110 24066228-2 2013 Because in many cell types CD73 (ecto-5"-nucleotidase) is important for the conversion of 5"-AMP to adenosine, we investigated whether CD73 is necessary for normal renal sympathetic neurotransmission. Adenosine Monophosphate 90-96 5' nucleotidase, ecto Mus musculus 33-53 23825434-1 2013 Prostatic acid phosphatase (PAP) and ecto-5"-nucleotidase (NT5E) hydrolyze extracellular AMP to adenosine in dorsal root ganglia (DRG) neurons and in the dorsal spinal cord. Adenosine Monophosphate 89-92 5' nucleotidase, ecto Mus musculus 37-57 23825434-1 2013 Prostatic acid phosphatase (PAP) and ecto-5"-nucleotidase (NT5E) hydrolyze extracellular AMP to adenosine in dorsal root ganglia (DRG) neurons and in the dorsal spinal cord. Adenosine Monophosphate 89-92 5' nucleotidase, ecto Mus musculus 59-63 23776700-1 2013 CD73 (ecto-5"-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. Adenosine Monophosphate 126-129 5' nucleotidase, ecto Mus musculus 6-26 23211965-3 2013 Inhibition of ecto-5"-nucleotidase-dependent constitutive degradation of brain extracellular AMP by methylene-ADP (AMPCP) also suffices to prompt A1R-dependent hypothermia without hypotension. Adenosine Monophosphate 93-96 5' nucleotidase, ecto Mus musculus 14-34 23093068-3 2013 Inhibition of constitutive degradation of brain extracellular AMP by targeting ecto 5"-nucleotidase, also suffices to prompt hypothermia in rodents. Adenosine Monophosphate 62-65 5' nucleotidase, ecto Mus musculus 79-99 23274765-2 2013 Extracellular adenosine is synthesized by the cell-surface ectoenzyme ecto-5"-nucleotidase (CD73) from 5"-adenosine monophosphate. Adenosine Monophosphate 103-129 5' nucleotidase, ecto Mus musculus 70-90 23274765-2 2013 Extracellular adenosine is synthesized by the cell-surface ectoenzyme ecto-5"-nucleotidase (CD73) from 5"-adenosine monophosphate. Adenosine Monophosphate 103-129 5' nucleotidase, ecto Mus musculus 92-96 23398498-1 2013 CONTEXT: CD73 converts extracellular AMP to adenosine which is well known to inhibit lipolysis. Adenosine Monophosphate 37-40 5' nucleotidase, ecto Mus musculus 9-13 22423104-5 2012 Here, we have used mice that lack the CD73 gene (encoding ecto-5"-nucleotidase that converts AMP to adenosine) to test whether action potential-dependent adenosine release in the cerebellum depends on prior ATP release. Adenosine Monophosphate 93-96 5' nucleotidase, ecto Mus musculus 58-78 22637533-6 2012 The generated ATP and AMP are then metabolized through the coupled nucleotide pyrophosphatase/phosphodiesterase and 5"-nucleotidase/CD73 reactions, respectively. Adenosine Monophosphate 22-25 5' nucleotidase, ecto Mus musculus 132-136 22875826-1 2012 Research on the biological roles of ectonucleoidases has revealed that CD73, an ecto-5 nucleotidase, plays a special role in the extracellular conversion of adenosine monophosphate to adenosine--specifically, as a checkpoint that determines whether the extracellular environment is proinflammatory (characterized by adenosine 5"-triphosphate-mediated responses) or anti-inflammatory (adenosine-mediated responses). Adenosine Monophosphate 157-180 5' nucleotidase, ecto Mus musculus 71-75 22875826-1 2012 Research on the biological roles of ectonucleoidases has revealed that CD73, an ecto-5 nucleotidase, plays a special role in the extracellular conversion of adenosine monophosphate to adenosine--specifically, as a checkpoint that determines whether the extracellular environment is proinflammatory (characterized by adenosine 5"-triphosphate-mediated responses) or anti-inflammatory (adenosine-mediated responses). Adenosine Monophosphate 157-180 5' nucleotidase, ecto Mus musculus 80-99 22396496-1 2012 CD73 is a cell surface 5"-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. Adenosine Monophosphate 53-56 5' nucleotidase, ecto Mus musculus 0-4 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Monophosphate 61-84 5' nucleotidase, ecto Mus musculus 264-268 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Monophosphate 86-89 5' nucleotidase, ecto Mus musculus 264-268 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Monophosphate 193-196 5' nucleotidase, ecto Mus musculus 264-268 22229268-6 2012 In addition, AMP and free radical concentrations were much higher in CD73(-/-) than that in CD73(+/+) mice. Adenosine Monophosphate 13-16 5' nucleotidase, ecto Mus musculus 69-73 22291183-2 2012 CD73 is an ecto-5" nucleotidase that catalyzes the terminal phosphohydrolysis of AMP and resides in the brain on glial cells, cells of the choroid plexus, and leukocytes. Adenosine Monophosphate 81-84 5' nucleotidase, ecto Mus musculus 0-4 22291183-2 2012 CD73 is an ecto-5" nucleotidase that catalyzes the terminal phosphohydrolysis of AMP and resides in the brain on glial cells, cells of the choroid plexus, and leukocytes. Adenosine Monophosphate 81-84 5' nucleotidase, ecto Mus musculus 11-31 20546740-1 2010 BACKGROUND & AIMS: Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Adenosine Monophosphate 12-15 5' nucleotidase, ecto Mus musculus 121-125 23118501-1 2012 CD73 is a glycosyl-phosphatidylinositol-(GPI-) linked membrane protein that catalyzes the extracellular dephosphorylation of adenosine monophosphate (AMP) to adenosine. Adenosine Monophosphate 125-148 5' nucleotidase, ecto Mus musculus 0-4 23118501-1 2012 CD73 is a glycosyl-phosphatidylinositol-(GPI-) linked membrane protein that catalyzes the extracellular dephosphorylation of adenosine monophosphate (AMP) to adenosine. Adenosine Monophosphate 150-153 5' nucleotidase, ecto Mus musculus 0-4 22011440-1 2011 BACKGROUND: Prostatic acid phosphatase (PAP) and ecto-5"-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generate adenosine or how rapidly they generate adenosine. Adenosine Monophosphate 135-138 5' nucleotidase, ecto Mus musculus 49-69 22011440-1 2011 BACKGROUND: Prostatic acid phosphatase (PAP) and ecto-5"-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generate adenosine or how rapidly they generate adenosine. Adenosine Monophosphate 135-138 5' nucleotidase, ecto Mus musculus 71-75 22011440-1 2011 BACKGROUND: Prostatic acid phosphatase (PAP) and ecto-5"-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generate adenosine or how rapidly they generate adenosine. Adenosine Monophosphate 135-138 5' nucleotidase, ecto Mus musculus 77-81 22011440-2 2011 RESULTS: We found that AMP hydrolysis, when measured histochemically, was nearly abolished in dorsal root ganglia (DRG) neurons and lamina II of spinal cord from Pap/Nt5e double knockout (dKO) mice. Adenosine Monophosphate 23-26 5' nucleotidase, ecto Mus musculus 166-170 21346249-1 2011 CD73 is involved in the extracellular ATP metabolism by dephosphorylating extracellular AMP to adenosine and thus regulating permeability of the blood vessels and leukocyte traffic into the tissues. Adenosine Monophosphate 88-91 5' nucleotidase, ecto Mus musculus 0-4 21807070-3 2011 They provide a major source of extracellular AMP, the substrate for adenosine production by ecto-5"-nucleotidase (NT5E), and thereby regulate adenosine (P1) receptor signaling. Adenosine Monophosphate 45-48 5' nucleotidase, ecto Mus musculus 92-112 21807070-3 2011 They provide a major source of extracellular AMP, the substrate for adenosine production by ecto-5"-nucleotidase (NT5E), and thereby regulate adenosine (P1) receptor signaling. Adenosine Monophosphate 45-48 5' nucleotidase, ecto Mus musculus 114-118 21770045-3 2011 In the presence of AMP, CD73 induced by TGF-beta generates adenosine able to suppress proliferation of activated CD4(+) T cells in vitro. Adenosine Monophosphate 19-22 5' nucleotidase, ecto Mus musculus 24-28 21424267-1 2011 Ecto-5"-nucleotidase (eNT/CD73, E.C.3.1.3.5) is a glycosyl phosphatidylinositol (GPI)-linked cell-surface protein with several functions, including the local generation of adenosine from AMP, with the consequent activation of adenosine receptors and the salvaging of extracellular nucleotides. Adenosine Monophosphate 187-190 5' nucleotidase, ecto Mus musculus 0-20 21424267-1 2011 Ecto-5"-nucleotidase (eNT/CD73, E.C.3.1.3.5) is a glycosyl phosphatidylinositol (GPI)-linked cell-surface protein with several functions, including the local generation of adenosine from AMP, with the consequent activation of adenosine receptors and the salvaging of extracellular nucleotides. Adenosine Monophosphate 187-190 5' nucleotidase, ecto Mus musculus 26-30 21424267-5 2011 Knockdown of eNT/CD73 leads to an increase in mRNA expression of tissue non-specific alkaline phosphatase (TNALP), another AMP-degrading enzyme and thus no alteration is seen in the total ecto-AMPase activity of the cell. Adenosine Monophosphate 123-126 5' nucleotidase, ecto Mus musculus 17-21 21469131-1 2011 CD73/ecto-5"-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. Adenosine Monophosphate 57-60 5' nucleotidase, ecto Mus musculus 0-4 21469131-1 2011 CD73/ecto-5"-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. Adenosine Monophosphate 57-60 5' nucleotidase, ecto Mus musculus 5-25 21390184-2 2011 CD39/ENTPD1 is the dominant ectonucleotidase expressed by endothelial cells and regulatory T cells and catalyzes the sequential hydrolysis of ATP to AMP that is further degraded to adenosine by CD73/ecto-5"-nucleotidase. Adenosine Monophosphate 149-152 5' nucleotidase, ecto Mus musculus 194-198 21390184-2 2011 CD39/ENTPD1 is the dominant ectonucleotidase expressed by endothelial cells and regulatory T cells and catalyzes the sequential hydrolysis of ATP to AMP that is further degraded to adenosine by CD73/ecto-5"-nucleotidase. Adenosine Monophosphate 149-152 5' nucleotidase, ecto Mus musculus 199-219 21063242-2 2010 Pericellular adenosine is generated by the hydrolysis of extracellular adenosine triphosphate and adenosine diphosphate by the ectonucleotidase CD39 and the subsequent hydrolysis of adenosine monophosphate (AMP) by the ectonucleotidase CD73. Adenosine Monophosphate 182-205 5' nucleotidase, ecto Mus musculus 236-240 20147550-0 2010 Ecto-5"-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. Adenosine Monophosphate 64-67 5' nucleotidase, ecto Mus musculus 0-20 20571465-13 2010 Further, studies in knock-out mice lacking ENTDP1 and NT5E (enzymes catalyzing formation and degradation of AMP, respectively) demonstrated a clear protective role for AMP in ischemia/reperfusion. Adenosine Monophosphate 108-111 5' nucleotidase, ecto Mus musculus 54-58 20571465-13 2010 Further, studies in knock-out mice lacking ENTDP1 and NT5E (enzymes catalyzing formation and degradation of AMP, respectively) demonstrated a clear protective role for AMP in ischemia/reperfusion. Adenosine Monophosphate 168-171 5' nucleotidase, ecto Mus musculus 54-58 20430891-3 2010 Wild type, ecto-5"-nucleotidase-deficient, and adenosine receptor-deficient mice undergo 5"-AMP-induced hypometabolism in a similar fashion. Adenosine Monophosphate 89-95 5' nucleotidase, ecto Mus musculus 11-31 20136797-6 2010 The purpose of the present study was to characterize in this system the expression profile of ecto-5"-nucleotidase (CD73), the enzyme generating adenosine from AMP. Adenosine Monophosphate 160-163 5' nucleotidase, ecto Mus musculus 94-114 20136797-6 2010 The purpose of the present study was to characterize in this system the expression profile of ecto-5"-nucleotidase (CD73), the enzyme generating adenosine from AMP. Adenosine Monophosphate 160-163 5' nucleotidase, ecto Mus musculus 116-120 20458493-6 2010 The purpose of the present study was to characterize in the male reproductive tract the expression profile of the main enzyme responsible for the generation of adenosine from AMP, namely the ecto-5"-nucleotidase (CD73). Adenosine Monophosphate 175-178 5' nucleotidase, ecto Mus musculus 191-211 20458493-6 2010 The purpose of the present study was to characterize in the male reproductive tract the expression profile of the main enzyme responsible for the generation of adenosine from AMP, namely the ecto-5"-nucleotidase (CD73). Adenosine Monophosphate 175-178 5' nucleotidase, ecto Mus musculus 213-217 20179192-3 2010 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 60-63 5' nucleotidase, ecto Mus musculus 12-32 20179192-3 2010 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 60-63 5' nucleotidase, ecto Mus musculus 45-49 20179192-3 2010 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 60-63 5' nucleotidase, ecto Mus musculus 127-131 20398264-1 2010 BACKGROUND: Ecto-5"-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in nociceptive circuits. Adenosine Monophosphate 113-116 5' nucleotidase, ecto Mus musculus 12-32 20398264-1 2010 BACKGROUND: Ecto-5"-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in nociceptive circuits. Adenosine Monophosphate 113-116 5' nucleotidase, ecto Mus musculus 34-38 20398264-1 2010 BACKGROUND: Ecto-5"-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in nociceptive circuits. Adenosine Monophosphate 113-116 5' nucleotidase, ecto Mus musculus 54-58 20398264-4 2010 Recombinant mNT5E hydrolyzed AMP in biochemical assays and was inhibited by alpha,beta-methylene-adenosine 5"-diphosphate (alpha,beta-me-ADP; IC50 = 0.43 microM), a selective inhibitor of NT5E. Adenosine Monophosphate 29-32 5' nucleotidase, ecto Mus musculus 12-17 20398264-4 2010 Recombinant mNT5E hydrolyzed AMP in biochemical assays and was inhibited by alpha,beta-methylene-adenosine 5"-diphosphate (alpha,beta-me-ADP; IC50 = 0.43 microM), a selective inhibitor of NT5E. Adenosine Monophosphate 29-32 5' nucleotidase, ecto Mus musculus 13-17 20398264-8 2010 CONCLUSION: Our data indicate that the long lasting antinociceptive effects of mNT5E are due to hydrolysis of AMP followed by activation of A1R. Adenosine Monophosphate 110-113 5' nucleotidase, ecto Mus musculus 79-84 20147550-0 2010 Ecto-5"-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. Adenosine Monophosphate 64-67 5' nucleotidase, ecto Mus musculus 22-26 20147550-1 2010 Ecto-5"-nucleotidase (NT5E, CD73) is a membrane-anchored protein that hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in diverse tissues but has not been directly studied in nociceptive neurons. Adenosine Monophosphate 123-126 5' nucleotidase, ecto Mus musculus 0-20 20147550-1 2010 Ecto-5"-nucleotidase (NT5E, CD73) is a membrane-anchored protein that hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in diverse tissues but has not been directly studied in nociceptive neurons. Adenosine Monophosphate 123-126 5' nucleotidase, ecto Mus musculus 22-26 20147550-1 2010 Ecto-5"-nucleotidase (NT5E, CD73) is a membrane-anchored protein that hydrolyzes extracellular adenosine 5"-monophosphate (AMP) to adenosine in diverse tissues but has not been directly studied in nociceptive neurons. Adenosine Monophosphate 123-126 5' nucleotidase, ecto Mus musculus 28-32 20147550-5 2010 In addition, AMP hydrolytic activity was reduced in DRG neurons and spinal cord of Nt5e(-/-) mice. Adenosine Monophosphate 13-16 5' nucleotidase, ecto Mus musculus 83-87 20147550-6 2010 The antinociceptive effects of AMP, when combined with the adenosine kinase inhibitor 5-iodotubericidin, were reduced by approximately 50% in Nt5e(-/-) mice and were eliminated in Adenosine A(1) receptor (A(1)R, Adora1) knock-out mice. Adenosine Monophosphate 31-34 5' nucleotidase, ecto Mus musculus 142-146 20147550-8 2010 Collectively, our data indicate that the ectonucleotidase NT5E regulates nociception by hydrolyzing AMP to adenosine in nociceptive circuits and represents a new molecular target for the treatment of chronic pain. Adenosine Monophosphate 100-103 5' nucleotidase, ecto Mus musculus 58-62 18424752-3 2008 CD73 produces adenosine from AMP and is expressed on high endothelial venules (HEV) and subsets of lymphocytes. Adenosine Monophosphate 29-32 5' nucleotidase, ecto Mus musculus 0-4 20080644-2 2010 We performed proof-of-concept studies investigating the therapeutic potential and mechanism of action of monoclonal antibody (mAb)-based therapy against CD73, an ecto-enzyme overexpressed on breast-cancer cells that catalyzes the dephosphorylation of adenosine monophosphates into adenosine. Adenosine Monophosphate 251-275 5' nucleotidase, ecto Mus musculus 153-157 19104409-9 2008 CONCLUSION: The relative protective effect of CD73 deletion in renal I/RI may reflect an effect of AMP accumulation. Adenosine Monophosphate 99-102 5' nucleotidase, ecto Mus musculus 46-50 19008478-1 2008 Ecto-5"-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5"-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function. Adenosine Monophosphate 72-98 5' nucleotidase, ecto Mus musculus 0-20 19008478-1 2008 Ecto-5"-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5"-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function. Adenosine Monophosphate 72-98 5' nucleotidase, ecto Mus musculus 22-26 19008478-8 2008 These data suggest a new paradigm in which phosphohydrolysis of adenosine monophosphate by CD73 on graft-resident or circulating cells diminishes transendothelial leukocyte trafficking and mitigates inflammatory and immune sequelae of cardiac transplantation via the A(2B)AR. Adenosine Monophosphate 64-87 5' nucleotidase, ecto Mus musculus 91-95 18353866-2 2008 Because extracellular adenosine generation is primarily produced via phosphohydrolysis from its precursor molecule adenosine-monophosphate (AMP) through the enzyme ecto-5"-nucleotidase (CD73), we examined the contribution of CD73-dependent adenosine production in modulation of intestinal ischemia-reperfusion (IR) injury. Adenosine Monophosphate 140-143 5' nucleotidase, ecto Mus musculus 186-190 18353866-2 2008 Because extracellular adenosine generation is primarily produced via phosphohydrolysis from its precursor molecule adenosine-monophosphate (AMP) through the enzyme ecto-5"-nucleotidase (CD73), we examined the contribution of CD73-dependent adenosine production in modulation of intestinal ischemia-reperfusion (IR) injury. Adenosine Monophosphate 140-143 5' nucleotidase, ecto Mus musculus 225-229 18591671-1 2008 CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine. Adenosine Monophosphate 94-97 5' nucleotidase, ecto Mus musculus 0-4 18263696-4 2008 Because ecto-5"-nucleotidase (CD73) catalyzes the terminal step in extracellular adenosine formation from AMP, we determined whether CD73 plays a role in the development of hepatic fibrosis. Adenosine Monophosphate 106-109 5' nucleotidase, ecto Mus musculus 8-28 18263696-4 2008 Because ecto-5"-nucleotidase (CD73) catalyzes the terminal step in extracellular adenosine formation from AMP, we determined whether CD73 plays a role in the development of hepatic fibrosis. Adenosine Monophosphate 106-109 5' nucleotidase, ecto Mus musculus 30-34 17855480-4 2007 Because the ecto-5-nucleotidase (CD73, conversion of AMP to adenosine) is considered the pacemaker of extracellular adenosine generation, we first tested the effect of blocking extracellular adenosine generation with the specific CD73-inhibitor adenosine 5"-(alpha,beta-methylene) diphosphate (APCP) or by gene-targeted deletion of cd73. Adenosine Monophosphate 53-56 5' nucleotidase, ecto Mus musculus 12-31 18037449-3 2008 Ecto-5"-nucleotidase/CD73 is a marker for the plasma membrane and is considered to be a key enzyme in the generation of adenosine in the extracellular medium, by transforming AMP into adenosine. Adenosine Monophosphate 175-178 5' nucleotidase, ecto Mus musculus 0-20 18037449-3 2008 Ecto-5"-nucleotidase/CD73 is a marker for the plasma membrane and is considered to be a key enzyme in the generation of adenosine in the extracellular medium, by transforming AMP into adenosine. Adenosine Monophosphate 175-178 5' nucleotidase, ecto Mus musculus 21-25 18037449-5 2008 We compared the extracellular metabolism of AMP and transcriptional levels of the ecto-5"-nucleotidase/CD73 and tissue non-specific alkaline phosphatase (TNALP) in activated and quiescent HSC of the mouse hepatic stellate cell line GRX. Adenosine Monophosphate 44-47 5' nucleotidase, ecto Mus musculus 103-107 17855480-4 2007 Because the ecto-5-nucleotidase (CD73, conversion of AMP to adenosine) is considered the pacemaker of extracellular adenosine generation, we first tested the effect of blocking extracellular adenosine generation with the specific CD73-inhibitor adenosine 5"-(alpha,beta-methylene) diphosphate (APCP) or by gene-targeted deletion of cd73. Adenosine Monophosphate 53-56 5' nucleotidase, ecto Mus musculus 33-37 14687921-2 2004 After the solubilization procedure, the eNT activity in the final extract was 9.2+/-2.5U/mg (nmol of phosphate released from AMP per min and per mg protein) in normal liver, and it rose to 16.1+/-3.9U/mg (P=0.005) in dystrophic liver. Adenosine Monophosphate 125-128 5' nucleotidase, ecto Mus musculus 40-43 17065216-3 2006 Ecto-5"-nucleotidase (CD73), the enzyme that generates adenosine from AMP, was demonstrated by immunocytochemistry in approximately 20% of anterior pituitary cells, and some of these cells colocalized with prolactin and growth hormone. Adenosine Monophosphate 70-73 5' nucleotidase, ecto Mus musculus 0-20 17065216-3 2006 Ecto-5"-nucleotidase (CD73), the enzyme that generates adenosine from AMP, was demonstrated by immunocytochemistry in approximately 20% of anterior pituitary cells, and some of these cells colocalized with prolactin and growth hormone. Adenosine Monophosphate 70-73 5' nucleotidase, ecto Mus musculus 22-26 17082591-0 2006 T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5"-adenosine monophosphate to adenosine. Adenosine Monophosphate 114-140 5' nucleotidase, ecto Mus musculus 56-60 17082591-2 2006 CD73 on both Treg and Thpp cells converted extracellular 5"-AMP to adenosine. Adenosine Monophosphate 57-63 5' nucleotidase, ecto Mus musculus 0-4 12370277-2 2002 Extracellular AMP is metabolized to adenosine by surface-expressed ecto-5"-nucleotidase (CD73) and subsequently activates surface adenosine receptors regulating endothelial and epithelial barrier function. Adenosine Monophosphate 14-17 5' nucleotidase, ecto Mus musculus 67-87 12370277-2 2002 Extracellular AMP is metabolized to adenosine by surface-expressed ecto-5"-nucleotidase (CD73) and subsequently activates surface adenosine receptors regulating endothelial and epithelial barrier function. Adenosine Monophosphate 14-17 5' nucleotidase, ecto Mus musculus 89-93 10577739-1 1999 Adenosine, derived from hydrolysis of 5"-AMP by 5"-nucleotidase activity, may be involved in coupling coronary blood flow to cardiac function and metabolism; it has been postulated as a cardioprotective substance in ischemic myocardium. Adenosine Monophosphate 38-44 5' nucleotidase, ecto Mus musculus 48-63 9675234-1 1998 Ecto-5"-nucleotidase (eNT) from mouse muscle has been purified after extraction with detergent followed by chromatography on concanavalin A- and AMP-Sepharose. Adenosine Monophosphate 145-148 5' nucleotidase, ecto Mus musculus 0-20 9675234-1 1998 Ecto-5"-nucleotidase (eNT) from mouse muscle has been purified after extraction with detergent followed by chromatography on concanavalin A- and AMP-Sepharose. Adenosine Monophosphate 145-148 5' nucleotidase, ecto Mus musculus 22-25