PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18786089-7	2008	When blood vessel and cultured endothelial cells from hypertensive animals are treated with nebivolol, there is a decrease in superoxide production and an increase in the expression and activity of endothelial NOS (eNOS).	Nebivolol	92-101	nitric oxide synthase 3	Homo sapiens	198-213	
27326226-8	2016	While beta-blockers generally provide comparable blood pressure reductions, only nebivolol demonstrated enhanced vasodilation and blood flow by increasing the expression of endothelial nitric oxide synthase and therefore increasing nitric oxide release from the endothelium.	Nebivolol	81-90	nitric oxide synthase 3	Homo sapiens	173-206	
24849208-11	2014	Moreover, nebivolol treatment significantly increased the phosphorylation of endothelial NOS (eNOS) and the expression of neuronal NOS (nNOS).	Nebivolol	10-19	nitric oxide synthase 3	Homo sapiens	77-92	
23395155-8	2013	Angiotensin-converting enzyme inhibitors, AT1 receptor blockers, statins, nebivolol and resveratrol have been shown to reverse eNOS uncoupling and to stimulate eNOS activity concurrently.	Nebivolol	74-83	nitric oxide synthase 3	Homo sapiens	127-131	
23395155-8	2013	Angiotensin-converting enzyme inhibitors, AT1 receptor blockers, statins, nebivolol and resveratrol have been shown to reverse eNOS uncoupling and to stimulate eNOS activity concurrently.	Nebivolol	74-83	nitric oxide synthase 3	Homo sapiens	160-164	
16716362-1	2006	Nebivolol is a highly selective beta(1)-adrenoceptor blocker with additional vasodilatory properties, which may be due to an endothelial-dependent beta(3)-adrenergic activation of the endothelial nitric oxide synthase (eNOS).	Nebivolol	0-9	nitric oxide synthase 3	Homo sapiens	184-217	
17512554-12	2007	Since cardiovascular diseases are often associated with the development of erectile dysfunction, the nebivolol-induced eNOS-activation in corpus cavernosum may be beneficial when treating patients suffering from cardiovascular disease.	Nebivolol	101-110	nitric oxide synthase 3	Homo sapiens	119-123	
16895546-0	2006	Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells.	Nebivolol	22-31	nitric oxide synthase 3	Homo sapiens	40-73	
12692005-0	2003	Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.	Nebivolol	0-9	nitric oxide synthase 3	Homo sapiens	28-35