PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1738157-2	1992	The mouse renin is complexed with a non-hydrolysable decapeptide analogue of rat angiotensinogen containing a hydroxyethylene isostere in place of the scissile bond.	hydroxyethylene isostere	110-134	renin	Homo sapiens	10-15	
3290485-3	1988	Peptide VIa,b with a gamma-lactam conformational constraint and a hydroxyethylene isostere at the cleavage site inhibited human plasma renin with an IC50 value of 6.5 nM.	hydroxyethylene isostere	66-90	renin	Homo sapiens	135-140	
16776501-1	2006	A formal total synthesis of the potent renin inhibitor aliskiren is disclosed exploiting an alternative coupling strategy recently developed by this laboratory for the preparation of the hydroxyethylene isostere-based class of protease inhibitors.	hydroxyethylene isostere	187-211	renin	Homo sapiens	39-44	
21112780-1	2011	Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized.	hydroxyethylene isostere	70-94	renin	Homo sapiens	38-43