PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7912015-6 1994 Consequently, 2-CdA is expected soon to displace both interferon alpha and deoxycoformycin as first line therapy in hairy cell leukemia. Pentostatin 75-90 cytidine deaminase Homo sapiens 16-19 9178835-2 1997 Recently, the high activity of nucleoside analogs as fludarabine (FAMP), 2-chlorodeoxyadenosine (2-CDA) and 2-deoxycoformycin (DCF) in low-grade NHLs has caused a new reawakening interest in CLL concerning new treatment strategies, the biology and prognostic factors of this disease. Pentostatin 127-130 cytidine deaminase Homo sapiens 99-102 21463108-8 2011 These additional modes of action produce further DNA breaks in CdA-treated cells and explain the more potent activity of CdA compared to dCF and the greater myelosuppression with this agent. Pentostatin 137-140 cytidine deaminase Homo sapiens 63-66 7685243-6 1993 Recently, the nucleosides pentostatin (2"-deoxycoformycin) (DCF) and 2"-chlorodeoxyadenosine (2-CdA) have been shown to produce greater numbers of durable complete remissions with curative potential in patients with HCL. Pentostatin 60-63 cytidine deaminase Homo sapiens 96-99 1279327-2 1992 Splenectomy as first line therapy has few indications; recombinant alfa interferon (IFN) leads to a high overall response rate but there are few bone marrow remissions; deoxycoformycin (dCF) or pentostatin leads to a higher complete bone marrow response rate than with IFN but follow-up biopsies show persistence of hairy cells; 2-chlorodeoxyadenosine (2-CdA) is a purine analog that after a single seven day intravenous infusion leads to a complete response rate. Pentostatin 169-184 cytidine deaminase Homo sapiens 355-358