PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11226375-6 2001 2"-Deoxycoformycin, an inhibitor of adenosine deaminase, enhanced caspase activation by adenosine but had no effect by itself. Pentostatin 0-18 adenosine deaminase Mus musculus 36-55 16670267-7 2006 Functional studies of murine hypoxia revealed inhibition of ADA with deoxycoformycin (dCF) enhances protective responses mediated by adenosine (vascular leak and neutrophil accumulation). Pentostatin 69-84 adenosine deaminase Mus musculus 60-63 16670267-7 2006 Functional studies of murine hypoxia revealed inhibition of ADA with deoxycoformycin (dCF) enhances protective responses mediated by adenosine (vascular leak and neutrophil accumulation). Pentostatin 86-89 adenosine deaminase Mus musculus 60-63 12091165-2 2002 Pentostatin (2"-deoxycoformycin), an inhibitor of adenosine deaminase, was administered to mice immediately after induction of sepsis by cecal ligation and puncture. Pentostatin 0-11 adenosine deaminase Mus musculus 50-69 12091165-2 2002 Pentostatin (2"-deoxycoformycin), an inhibitor of adenosine deaminase, was administered to mice immediately after induction of sepsis by cecal ligation and puncture. Pentostatin 13-31 adenosine deaminase Mus musculus 50-69 9622483-2 1998 The X-ray structures of murine adenosine deaminase with bound potent inhibitors (Ki values approximately 10(-13) M) (8R)-hydroxyl-2"-deoxycoformycin (pentostatin), a transition state analogue, and (6S)-hydroxyl-1,6-dihydropurine riboside, a reaction coordinate analogue, have been determined and refined to resolutions of 2.6 and 1.95 A, respectively. Pentostatin 150-161 adenosine deaminase Mus musculus 31-50 1731400-1 1992 The viability of early mouse embryos is acutely sensitive to (R)-deoxycoformycin (pentostatin), a tight-binding inhibitor of adenosine deaminase (ADA). Pentostatin 61-80 adenosine deaminase Mus musculus 125-144 9045870-5 1997 Thymic adenosine concentrations of mice treated with the ADA inhibitor 2"-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5"-NT, is mainly responsible for low thymic adenosine levels. Pentostatin 71-89 adenosine deaminase Mus musculus 57-60 9045870-5 1997 Thymic adenosine concentrations of mice treated with the ADA inhibitor 2"-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5"-NT, is mainly responsible for low thymic adenosine levels. Pentostatin 71-89 adenosine deaminase Mus musculus 145-148 9045870-5 1997 Thymic adenosine concentrations of mice treated with the ADA inhibitor 2"-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5"-NT, is mainly responsible for low thymic adenosine levels. Pentostatin 91-94 adenosine deaminase Mus musculus 57-60 9045870-5 1997 Thymic adenosine concentrations of mice treated with the ADA inhibitor 2"-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5"-NT, is mainly responsible for low thymic adenosine levels. Pentostatin 91-94 adenosine deaminase Mus musculus 145-148 9045870-6 1997 The adenosine concentrations in dCF-treated mice are sufficient to cause adenosine receptor-mediated thymocyte apoptosis in vitro, suggesting that adenosine accumulation could play a role in ADA-deficient severe combined immunodeficiency. Pentostatin 32-35 adenosine deaminase Mus musculus 191-194 7669942-5 1995 Inhibition of the adenosine deaminase by deoxycoformycin permits a 6-fold increase in intracellular adenosine concentration relative to the medium by the Na(+)-dependent process. Pentostatin 41-56 adenosine deaminase Mus musculus 18-37 7669942-6 1995 Rapid inhibition of adenosine deaminase by deoxycoformycin occurs even in the presence of dipyridamole which prevents the entry of deoxycoformycin as well as adenosine into the cells in a Na(+)-free medium. Pentostatin 43-58 adenosine deaminase Mus musculus 20-39 7669942-6 1995 Rapid inhibition of adenosine deaminase by deoxycoformycin occurs even in the presence of dipyridamole which prevents the entry of deoxycoformycin as well as adenosine into the cells in a Na(+)-free medium. Pentostatin 131-146 adenosine deaminase Mus musculus 20-39 1731400-1 1992 The viability of early mouse embryos is acutely sensitive to (R)-deoxycoformycin (pentostatin), a tight-binding inhibitor of adenosine deaminase (ADA). Pentostatin 61-80 adenosine deaminase Mus musculus 146-149 1731400-1 1992 The viability of early mouse embryos is acutely sensitive to (R)-deoxycoformycin (pentostatin), a tight-binding inhibitor of adenosine deaminase (ADA). Pentostatin 82-93 adenosine deaminase Mus musculus 125-144 1731400-1 1992 The viability of early mouse embryos is acutely sensitive to (R)-deoxycoformycin (pentostatin), a tight-binding inhibitor of adenosine deaminase (ADA). Pentostatin 82-93 adenosine deaminase Mus musculus 146-149 1826794-2 1991 To clarify the process whereby thymocytes are destroyed in the absence of adenosine deaminase activity, we induced a parallel condition in mice through the injection of an inhibitor of adenosine deaminase, deoxycoformycin. Pentostatin 206-221 adenosine deaminase Mus musculus 185-204 2623648-0 1989 Early postimplantation embryolethality in mice following in utero inhibition of adenosine deaminase with 2"-deoxycoformycin. Pentostatin 105-123 adenosine deaminase Mus musculus 80-99 1761363-0 1991 Host resistance to murine malaria in mice exposed to the adenosine deaminase inhibitor, 2"-deoxycoformycin. Pentostatin 88-106 adenosine deaminase Mus musculus 57-76 1761363-2 1991 The purpose this study was to profile host resistance to infection with this organism in mice exposed to 2"-deoxycoformycin (2dCF), a potent adenosine deaminase (ADA) inhibitor. Pentostatin 105-123 adenosine deaminase Mus musculus 141-160 1761363-2 1991 The purpose this study was to profile host resistance to infection with this organism in mice exposed to 2"-deoxycoformycin (2dCF), a potent adenosine deaminase (ADA) inhibitor. Pentostatin 105-123 adenosine deaminase Mus musculus 162-165 1761363-2 1991 The purpose this study was to profile host resistance to infection with this organism in mice exposed to 2"-deoxycoformycin (2dCF), a potent adenosine deaminase (ADA) inhibitor. Pentostatin 125-129 adenosine deaminase Mus musculus 141-160 1761363-2 1991 The purpose this study was to profile host resistance to infection with this organism in mice exposed to 2"-deoxycoformycin (2dCF), a potent adenosine deaminase (ADA) inhibitor. Pentostatin 125-129 adenosine deaminase Mus musculus 162-165 1761363-3 1991 Inhibition of ADA activity by 2dFC results in defective T-cell function and either suppression or augmentation of the humoral response, depending on whether 2dCF exposure precedes (suppression) or follows (augmentation) immunization. Pentostatin 157-161 adenosine deaminase Mus musculus 14-17 2139230-5 1990 Cultures containing 10(-7) M 2"-deoxycoformycin retained approximately 10% of residual ADA activity of control cultures. Pentostatin 29-47 adenosine deaminase Mus musculus 87-90 2623648-4 1989 In the present study, we examined the effects of intrauterine exposure to 2"-deoxycoformycin (dCF; pentostatin), a potent irreversible inhibitor of ADA, on early postimplantation development. Pentostatin 74-92 adenosine deaminase Mus musculus 148-151 2623648-4 1989 In the present study, we examined the effects of intrauterine exposure to 2"-deoxycoformycin (dCF; pentostatin), a potent irreversible inhibitor of ADA, on early postimplantation development. Pentostatin 94-97 adenosine deaminase Mus musculus 148-151 2623648-9 1989 Treatment of pregnant dams with dCF on day 7 produced a complete (greater than 99%) inhibition of ADA activity in the antimesometrial decidua by 30 min, induced excessive cell death in the prospective neural plate and primary mesenchyme of the trilaminar disc by 6 h, and arrested embryonic development at an early somite stage. Pentostatin 32-35 adenosine deaminase Mus musculus 98-101 421226-0 1979 Recovery of 2"-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo. Pentostatin 12-30 adenosine deaminase Mus musculus 41-60 2836002-2 1988 Adenosine deaminase activity of 6C3HED cells was ablated by incubation with 10(-6) mol/L deoxycoformycin (dCF). Pentostatin 89-104 adenosine deaminase Mus musculus 0-19 2836002-2 1988 Adenosine deaminase activity of 6C3HED cells was ablated by incubation with 10(-6) mol/L deoxycoformycin (dCF). Pentostatin 106-109 adenosine deaminase Mus musculus 0-19 2428625-10 1986 It is identical to the activity of C57BL/6 thymic cells or C57BL/6 T tumor lines regarding its sensitivity to ADA inhibitors 2-deoxycoformycin and erythro-9-(2-hydroxyl-3-nonyl)adenine, and its electrophoretic mobility under nondenaturing conditions (starch gel and isoelectric focusing). Pentostatin 125-142 adenosine deaminase Mus musculus 110-113 3840153-4 1985 The aglycone of adechlorin was identical with that of the known adenosine deaminase inhibitors coformycin and 2"-deoxycoformycin. Pentostatin 110-128 adenosine deaminase Mus musculus 64-83 3840153-6 1985 The Ki values for adechlorin, coformycin and 2"-deoxycoformycin against adenosine deaminase were determined to be 5.3 X 10(-10) M, 2.1 X 10(-10) M and 7.6 X 10(-11) M, respectively. Pentostatin 45-63 adenosine deaminase Mus musculus 72-91 3873908-4 1985 When dCF-resistant rat hepatoma and mouse cells are selected by increasing the concentration of the inhibitor in small increments, there is a good correlation between the increase in ADA gene copy number and the increase in the level of expression of ADA, suggesting that all of the amplified genes are equally active in the expression of ADA. Pentostatin 5-8 adenosine deaminase Mus musculus 183-186 3873908-4 1985 When dCF-resistant rat hepatoma and mouse cells are selected by increasing the concentration of the inhibitor in small increments, there is a good correlation between the increase in ADA gene copy number and the increase in the level of expression of ADA, suggesting that all of the amplified genes are equally active in the expression of ADA. Pentostatin 5-8 adenosine deaminase Mus musculus 251-254 3873908-4 1985 When dCF-resistant rat hepatoma and mouse cells are selected by increasing the concentration of the inhibitor in small increments, there is a good correlation between the increase in ADA gene copy number and the increase in the level of expression of ADA, suggesting that all of the amplified genes are equally active in the expression of ADA. Pentostatin 5-8 adenosine deaminase Mus musculus 251-254 6362851-2 1984 In the presence of dipyridamole and 2"-deoxyadenosine and when adenosine deaminase was inhibited with deoxycoformycin, the L1210 leukemia cell which is a non-T-, non-B-cell type accumulated dATP like a T-cell type. Pentostatin 102-117 adenosine deaminase Mus musculus 63-82 6347398-2 1983 The effect of deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase, on the ability of mouse spleen cells to generate antibody responses in vitro has been examined. Pentostatin 14-29 adenosine deaminase Mus musculus 59-78 6347398-2 1983 The effect of deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase, on the ability of mouse spleen cells to generate antibody responses in vitro has been examined. Pentostatin 31-34 adenosine deaminase Mus musculus 59-78 6602803-7 1983 We used 11AAU selection in conjunction with stepwise selection for increasing resistance to deoxycoformycin, an adenosine deaminase inhibitor, to obtain highly drug-resistant cells with a 6000-fold increase in adenosine deaminase activity. Pentostatin 92-107 adenosine deaminase Mus musculus 112-131 6602803-7 1983 We used 11AAU selection in conjunction with stepwise selection for increasing resistance to deoxycoformycin, an adenosine deaminase inhibitor, to obtain highly drug-resistant cells with a 6000-fold increase in adenosine deaminase activity. Pentostatin 92-107 adenosine deaminase Mus musculus 210-229 6602803-8 1983 Adenosine deaminase accounted for approximately 50% of the soluble protein in highly drug-resistant lines and was indistinguishable from that in the parent as judged by isoelectric focusing, electrophoretic mobility on starch gels, and by deoxycoformycin binding studies. Pentostatin 239-254 adenosine deaminase Mus musculus 0-19 6968908-1 1980 An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2"-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). Pentostatin 121-139 adenosine deaminase Mus musculus 187-206 6968908-1 1980 An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2"-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). Pentostatin 121-139 adenosine deaminase Mus musculus 208-213 6968908-1 1980 An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2"-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). Pentostatin 141-144 adenosine deaminase Mus musculus 187-206 6968908-1 1980 An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2"-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). Pentostatin 141-144 adenosine deaminase Mus musculus 208-213 6968908-2 1980 After DCF infusion, ADase of thymus, spleen, and lymph nodes was inhibited to varying degrees ranging from 57% to 100%. Pentostatin 6-9 adenosine deaminase Mus musculus 20-25 6966932-0 1980 Hemolysis in mice treated with deoxycoformycin, an inhibitor of adenosine deaminase. Pentostatin 31-46 adenosine deaminase Mus musculus 64-83 6970629-1 1980 Deoxycoformycin, a tight-binding inhibitor of the enzyme adenosine deaminase, is a potent lymphocytotoxic agent. Pentostatin 0-15 adenosine deaminase Mus musculus 57-76 6606032-1 1983 Pentostatin (I), a tight-binding inhibitor of adenosine deaminase, was evaluated in combination with the partially effective antitumor nucleoside N6-(delta 2-isopentenyl)adenosine (II) for cytotoxic activity against cultured L-1210 lymphocytic mouse leukemia cells. Pentostatin 0-11 adenosine deaminase Mus musculus 46-65 6604884-1 1983 The tight-binding adenosine deaminase inhibitor, 2"-deoxycoformycin (dCF), was continuously infused into mice by intraperitoneal implantation of microosmotic pumps delivering the compound at a rate of 0.16 mg hr-1 kg-1 for up to 6 days. Pentostatin 49-67 adenosine deaminase Mus musculus 18-37 6604884-1 1983 The tight-binding adenosine deaminase inhibitor, 2"-deoxycoformycin (dCF), was continuously infused into mice by intraperitoneal implantation of microosmotic pumps delivering the compound at a rate of 0.16 mg hr-1 kg-1 for up to 6 days. Pentostatin 69-72 adenosine deaminase Mus musculus 18-37 6980005-1 1982 The accumulation of deoxyadenosine triphosphate (dATP) in erythrocytes of mice treated with the adenosine deaminase inhibitor deoxycoformycin was studied in an attempt to establish and evaluate a model system for the study of at least some biochemical aspects of hereditary adenosine deaminase deficiency. Pentostatin 126-141 adenosine deaminase Mus musculus 96-115 455289-0 1979 Effects of 2"-deoxycoformycin infusion on mouse adenosine deaminase. Pentostatin 11-29 adenosine deaminase Mus musculus 48-67 311477-4 1979 However, in the presence of deoxycoformycin, a potent inhibitor of adenosine deaminase, these macrophages also excreted deoxyadenosine. Pentostatin 28-43 adenosine deaminase Mus musculus 67-86 421226-1 1979 The antibiotic 2"-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Pentostatin 15-33 adenosine deaminase Mus musculus 57-76 944095-1 1976 2"-Deoxycoformycin (2"-dCF), a potent inhibitor of adenosine deaminase, was tested in combination with 9-beta-D-arabinofuranosyladenine (ara-A) and 9-beta-D-arabinofuranosyladenine 5"-formate for cytotoxic activity against mouse leukemia L1210 in culture. Pentostatin 0-18 adenosine deaminase Mus musculus 51-70 301772-1 1977 The growth of cultured L5178Y cells is inhibited by relatively low concentrations fo deoxyadenosine in the presence of deoxycoformycin, an inhibitor of adenosine deaminase. Pentostatin 119-134 adenosine deaminase Mus musculus 152-171 280146-5 1977 The administration of an inhibitor of adenosine deaminase (Co-vidarabine) in combination with ara-A resulted in an enhanced antiviral response in both infected cell cultures and animals. Pentostatin 59-72 adenosine deaminase Mus musculus 38-57 750104-2 1978 To examine the in vivo effects of inhibition of this enzyme healthy BDF1 mice were injected intraperitoneally with 2"-deoxycoformycin, a stoichiometric tight-binding inhibitor of adenosine deaminase. Pentostatin 115-133 adenosine deaminase Mus musculus 179-198 301901-1 1977 The relationship between adenosine deaminase deficiency and immunologic responsiveness was studied in mice treated in vivo with deoxycoformycin to produce very low levels of adenosine deaminase activity in tissues. Pentostatin 128-143 adenosine deaminase Mus musculus 25-44 301901-1 1977 The relationship between adenosine deaminase deficiency and immunologic responsiveness was studied in mice treated in vivo with deoxycoformycin to produce very low levels of adenosine deaminase activity in tissues. Pentostatin 128-143 adenosine deaminase Mus musculus 174-193 301901-3 1977 Under the conditions used, inhibition of adenosine deaminase by deoxycoformycin had no effect on the viability or responsiveness of either thymocytes or splenic cells. Pentostatin 64-79 adenosine deaminase Mus musculus 41-60 944095-1 1976 2"-Deoxycoformycin (2"-dCF), a potent inhibitor of adenosine deaminase, was tested in combination with 9-beta-D-arabinofuranosyladenine (ara-A) and 9-beta-D-arabinofuranosyladenine 5"-formate for cytotoxic activity against mouse leukemia L1210 in culture. Pentostatin 20-26 adenosine deaminase Mus musculus 51-70 944095-5 1976 Potentiation of ara-A activity against the relatively insensitive mouse leukemia L1210 was attributed to increased stability of ara-A resulting from 2"-dCF inhibition of adenosine deaminase. Pentostatin 149-155 adenosine deaminase Mus musculus 170-189 23361035-1 2013 The aim of this study was to evaluate the anti-trypanosomal effect of treatment with 3"-deoxyadenosine (cordycepin) combined with deoxycoformycin (pentostatin: inhibitor of the enzyme adenosine deaminase) in vitro by using mice experimentally infected with Trypanosoma evansi. Pentostatin 130-145 adenosine deaminase Mus musculus 184-203 27217381-8 2017 ECoG depression was also shortened by focal application of exogenous adenosine deaminase (ADA; 100 U/mL), and conversely, was prolonged 50% by the non-competitive ADA inhibitor deoxycoformycin (DCF; 100 microM). Pentostatin 177-192 adenosine deaminase Mus musculus 90-93 27217381-8 2017 ECoG depression was also shortened by focal application of exogenous adenosine deaminase (ADA; 100 U/mL), and conversely, was prolonged 50% by the non-competitive ADA inhibitor deoxycoformycin (DCF; 100 microM). Pentostatin 177-192 adenosine deaminase Mus musculus 163-166 27217381-8 2017 ECoG depression was also shortened by focal application of exogenous adenosine deaminase (ADA; 100 U/mL), and conversely, was prolonged 50% by the non-competitive ADA inhibitor deoxycoformycin (DCF; 100 microM). Pentostatin 194-197 adenosine deaminase Mus musculus 90-93 23933282-0 2013 Influence of treatment with 3"-deoxyadenosine associated deoxycoformycin on hematological parameters and activity of adenosine deaminase in infected mice with Trypanosoma evansi. Pentostatin 57-72 adenosine deaminase Mus musculus 117-136 23933282-1 2013 This study aimed to verify the effect of 3"-deoxyadenosine and deoxycoformycin on hematologic parameters and adenosine deaminase (ADA) activity in plasma and brain of mice infected with Trypanosoma evansi. Pentostatin 63-78 adenosine deaminase Mus musculus 109-128 23933282-10 2013 The deoxycoformycin was able to inhibit the ADA activity of parasite thus it may be one of the mechanisms of efficacy of this treatment. Pentostatin 4-19 adenosine deaminase Mus musculus 44-47 23361035-1 2013 The aim of this study was to evaluate the anti-trypanosomal effect of treatment with 3"-deoxyadenosine (cordycepin) combined with deoxycoformycin (pentostatin: inhibitor of the enzyme adenosine deaminase) in vitro by using mice experimentally infected with Trypanosoma evansi. Pentostatin 147-158 adenosine deaminase Mus musculus 184-203