PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19837953-2	2010	NO can combine with superoxide to produce peroxynitrite, which activates matrix metalloproteinases (MMPs).	Superoxides	20-30	matrix metallopeptidase 2	Rattus norvegicus	100-104	
25804229-12	2015	In turn, activation of MMPs via superoxide-depending regulation allows tumor cells to facilitate migration, invasion and finally - formation of metastatic centers.	Superoxides	32-42	matrix metallopeptidase 2	Rattus norvegicus	23-27	
22447222-14	2012	These changes in tissue MMP-2 were connected with stimulation of Akt kinase activation, inhibition of SOD, an increase in superoxide levels, induction of iNOS protein expression and caspase-3 activation.	Superoxides	122-132	matrix metallopeptidase 2	Rattus norvegicus	24-29	
19345729-6	2009	Glucose-induced activation of retinal capillary cell MMP-2 and MT1-MMP and decrease in TIMP-2 were inhibited by superoxide scavengers, and their accelerated apoptosis was prevented by the inhibitors of MMP-2.	Superoxides	112-122	matrix metallopeptidase 2	Rattus norvegicus	53-58	
19345729-6	2009	Glucose-induced activation of retinal capillary cell MMP-2 and MT1-MMP and decrease in TIMP-2 were inhibited by superoxide scavengers, and their accelerated apoptosis was prevented by the inhibitors of MMP-2.	Superoxides	112-122	matrix metallopeptidase 2	Rattus norvegicus	202-207	
19345729-8	2009	Thus, MMP-2 has a proapoptotic role in the loss of retinal capillary cells in diabetes, and the activation of MMP-2 is under the control of superoxide.	Superoxides	140-150	matrix metallopeptidase 2	Rattus norvegicus	110-115	
19345729-4	2009	The effects of mitochondrial superoxide scavenger on glucose-induced alterations in MMP-2, and its proenzyme activator MT1-MMP and physiological inhibitor TIMP-2, were determined in retinal endothelial cells, and the regulation of their glucose-induced accelerated apoptosis by the inhibitors of MMP-2 was accessed.	Superoxides	29-39	matrix metallopeptidase 2	Rattus norvegicus	84-89	
15130778-14	2004	The results also suggest that caution needs to be taken when interpreting the reported results on activation of MMPs where X/XO had been used as an "authentic" source of superoxide anion.	Superoxides	170-186	matrix metallopeptidase 2	Rattus norvegicus	112-116