PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31264901-3 2020 OBJECTIVES: We tested the hypothesis that Src/epidermal growth factor receptor signaling mediates enhanced vasoconstrictor sensitivity following chronic hypoxia through NADPH oxidase-derived superoxide generation. Superoxides 191-201 epidermal growth factor receptor Rattus norvegicus 46-78 9933760-5 1999 These results suggested that superoxide anion/hydrogen peroxide generated during the ischemia-reperfusion other than EGF could act as an activator for the EGFR. Superoxides 29-45 epidermal growth factor receptor Rattus norvegicus 155-159 31264901-8 2020 Consistently, chronic hypoxia augmented endothelin-1-induced superoxide production through epidermal growth factor receptor signaling, and rats treated chronically with gefitinib displayed reduced right ventricular pressure and diminished arterial remodeling. Superoxides 61-71 epidermal growth factor receptor Rattus norvegicus 91-123 22174146-6 2011 Similarly, an increase in superoxide anion promoted by an equipotent dose of aldosterone (10 nmol l(-1)) was blocked by spironolactone or eplerenone, by preventing epidermal growth factor receptor transactivation, but not by inhibiting glucocorticoid receptors or protein synthesis, suggesting non-genomic MR effects. Superoxides 26-42 epidermal growth factor receptor Rattus norvegicus 164-196 21712088-5 2011 Furthermore, the enhanced phosphorylation of EGFR in VSMC from SHR was also restored to control levels by captopril, losartan, PP2, a c-Src inhibitor and N-acetyl-L-cysteine (NAC), superoxide anion (O(2)(-)) scavenger, whereas enhanced ERK1/2 phosphorylation was attenuated by captopril and losartan. Superoxides 181-197 epidermal growth factor receptor Rattus norvegicus 45-49 21712088-5 2011 Furthermore, the enhanced phosphorylation of EGFR in VSMC from SHR was also restored to control levels by captopril, losartan, PP2, a c-Src inhibitor and N-acetyl-L-cysteine (NAC), superoxide anion (O(2)(-)) scavenger, whereas enhanced ERK1/2 phosphorylation was attenuated by captopril and losartan. Superoxides 199-203 epidermal growth factor receptor Rattus norvegicus 45-49