PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8771562-0 1996 Neutrophil signal transduction in Met-enkephalin modulated superoxide anion release. Superoxides 59-75 proopiomelanocortin Homo sapiens 34-48 8771562-4 1996 MENK induced O2- release was associated with a dose-dependent increase of diacylglycerol (DAG) concentration and protein-kinase C (PKC) translocation to the neutrophil membranes, with an increase of cytosolic Ca++, and could be abolished by H7, a PKC inhibitor. Superoxides 13-15 proopiomelanocortin Homo sapiens 0-4 8771562-6 1996 Superoxide anion release induced by low concentrations of MENK (10(12)-10(-10) M), could be blocked by NDGA, an inhibitor of the lipoxygenase pathway. Superoxides 0-16 proopiomelanocortin Homo sapiens 58-62 8771562-1 1996 The present study explored the involvement of signal transduction system(s) in Met-enkephalin (MENK) modulated superoxide anion (O2-) release from human neutrophils. Superoxides 111-127 proopiomelanocortin Homo sapiens 79-93 8771562-7 1996 We concluded that MENK-induced O2- release results mainly due to DAG/PKC pathway activation, although other secondary messengers might be involved. Superoxides 31-33 proopiomelanocortin Homo sapiens 18-22 8771562-1 1996 The present study explored the involvement of signal transduction system(s) in Met-enkephalin (MENK) modulated superoxide anion (O2-) release from human neutrophils. Superoxides 111-127 proopiomelanocortin Homo sapiens 95-99 8771562-1 1996 The present study explored the involvement of signal transduction system(s) in Met-enkephalin (MENK) modulated superoxide anion (O2-) release from human neutrophils. Superoxides 129-131 proopiomelanocortin Homo sapiens 79-93 8771562-1 1996 The present study explored the involvement of signal transduction system(s) in Met-enkephalin (MENK) modulated superoxide anion (O2-) release from human neutrophils. Superoxides 129-131 proopiomelanocortin Homo sapiens 95-99 8771562-3 1996 The most abundant product of MENK degradation, Tyr-Gly-Gly (TGG), suppressed O2- release over a wide range of concentrations (10(-12)-10(-8) M). Superoxides 77-79 proopiomelanocortin Homo sapiens 29-33 10985929-0 2000 The link between met-enkephalin-induced down-regulation of APN activity and the release of superoxide anion. Superoxides 91-107 proopiomelanocortin Homo sapiens 17-31 8247257-1 1993 The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2-) release from human polymorphonuclear cells (PMN). Superoxides 194-210 proopiomelanocortin Homo sapiens 167-181 8247257-1 1993 The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2-) release from human polymorphonuclear cells (PMN). Superoxides 194-210 proopiomelanocortin Homo sapiens 183-187 8247257-1 1993 The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2-) release from human polymorphonuclear cells (PMN). Superoxides 212-214 proopiomelanocortin Homo sapiens 167-181 8247257-1 1993 The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2-) release from human polymorphonuclear cells (PMN). Superoxides 212-214 proopiomelanocortin Homo sapiens 183-187 8247257-2 1993 MENK (10(-8) M) abolished suppressed O2- release from PMNs treated with 10(-7) M DEX. Superoxides 37-39 proopiomelanocortin Homo sapiens 0-4 1327300-0 1992 Naloxone is an inappropriate antagonist of met-enkephalin-modulated superoxide anion release. Superoxides 68-84 proopiomelanocortin Homo sapiens 43-57 1327300-1 1992 Met-enkephalin (MENK) increased superoxide anion release by human polymorphonuclear cells (PMNs) at a physiological (10(-10) M) concentration and decreased release at a relatively high (10(-8) M) concentration. Superoxides 32-48 proopiomelanocortin Homo sapiens 0-14 1327300-1 1992 Met-enkephalin (MENK) increased superoxide anion release by human polymorphonuclear cells (PMNs) at a physiological (10(-10) M) concentration and decreased release at a relatively high (10(-8) M) concentration. Superoxides 32-48 proopiomelanocortin Homo sapiens 16-20 1327300-4 1992 NAL and MENK also had a combined influence on O2- release. Superoxides 46-48 proopiomelanocortin Homo sapiens 8-12 1327300-7 1992 The fact that NAL and MENK mutually interfere with one another in their effect upon O2- release by human PMNs discredits NAL as an appropriate antagonist in this system. Superoxides 84-86 proopiomelanocortin Homo sapiens 22-26 3039121-0 1987 Beta-endorphin stimulates human polymorphonuclear leukocyte superoxide production via a stereoselective opiate receptor. Superoxides 60-70 proopiomelanocortin Homo sapiens 0-14 3039121-3 1987 In this study we used a ferricytochrome C reduction microassay to measure superoxide (O2-) production by human polymorphonuclear leukocytes after stimulation with beta-endorphin (beta-END). Superoxides 74-84 proopiomelanocortin Homo sapiens 163-177 3039121-3 1987 In this study we used a ferricytochrome C reduction microassay to measure superoxide (O2-) production by human polymorphonuclear leukocytes after stimulation with beta-endorphin (beta-END). Superoxides 74-84 proopiomelanocortin Homo sapiens 179-187 9950265-0 1999 The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release. Superoxides 57-73 proopiomelanocortin Homo sapiens 32-46