PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7601250-1 1995 Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner. Superoxides 106-116 interleukin 1 beta Homo sapiens 47-56 7601250-1 1995 Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner. Superoxides 118-120 interleukin 1 beta Homo sapiens 47-56 7601250-1 1995 Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner. Superoxides 213-215 interleukin 1 beta Homo sapiens 47-56 1309493-7 1992 Superoxide anion production and candicidal activity were measured in the presence of TNF-alpha and IL-1 beta. Superoxides 0-16 interleukin 1 beta Homo sapiens 99-108 8174315-2 1994 Exposure of adherent peripheral blood PMN to cytokines known to be present in RA joints (IL-1 beta, TNF-alpha, GM-CSF) resulted in enhanced O2- production from both RA and controls. Superoxides 140-142 interleukin 1 beta Homo sapiens 89-98 7843804-7 1994 IL-6 inhibited superoxide production by chondrocytes both in IL-1 beta-stimulated or unstimulated conditions. Superoxides 15-25 interleukin 1 beta Homo sapiens 61-70 1382715-7 1992 PMN surviving in response to LPS or IL-1 beta retained the capacity to produce superoxide anion when treated with phorbol esters or fMLP. Superoxides 79-95 interleukin 1 beta Homo sapiens 36-45 1309493-9 1992 Diminished TNF-alpha and IL-1 beta binding reduced superoxide anion production by group 2 polymorphonuclear leukocytes. Superoxides 51-67 interleukin 1 beta Homo sapiens 25-34 1649133-0 1991 Effects of recombinant human IL-1 beta on production of prostaglandin E2, leukotriene B4, NAG, and superoxide by human synovial cells and chondrocytes. Superoxides 99-109 interleukin 1 beta Homo sapiens 29-38 1649133-4 1991 IL-1 beta significantly suppressed the release of NAG and superoxide by synovial cells, whereas it significantly enhanced the production of NAG and superoxide by chondrocytes. Superoxides 58-68 interleukin 1 beta Homo sapiens 0-9 1649133-4 1991 IL-1 beta significantly suppressed the release of NAG and superoxide by synovial cells, whereas it significantly enhanced the production of NAG and superoxide by chondrocytes. Superoxides 148-158 interleukin 1 beta Homo sapiens 0-9 2540256-1 1989 Both purified human monocyte interleukin-1 and recombinant interleukin-1 (beta) primed neutrophils for increased superoxide production and chemiluminescence in response to f-met-leu-phe. Superoxides 113-123 interleukin 1 beta Homo sapiens 59-79 2172157-2 1990 The generation of superoxide by Epstein-Barr virus (EBV)-transformed human B lymphocytes can be stimulated by a range of compounds; receptor-dependent stimuli include tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and lipopolysaccharides (LPS), and independent stimuli include AlF3, A21387 and ionomycin. Superoxides 18-28 interleukin 1 beta Homo sapiens 209-227 2172157-2 1990 The generation of superoxide by Epstein-Barr virus (EBV)-transformed human B lymphocytes can be stimulated by a range of compounds; receptor-dependent stimuli include tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and lipopolysaccharides (LPS), and independent stimuli include AlF3, A21387 and ionomycin. Superoxides 18-28 interleukin 1 beta Homo sapiens 229-238 26456836-11 2015 Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression. Superoxides 24-40 interleukin 1 beta Homo sapiens 170-178 2838419-5 1988 However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA. Superoxides 105-115 interleukin 1 beta Homo sapiens 60-69 3023484-4 1986 Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1. Superoxides 0-16 interleukin 1 beta Homo sapiens 193-197 3023484-6 1986 At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1. Superoxides 69-85 interleukin 1 beta Homo sapiens 116-120 3023484-8 1986 When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production. Superoxides 130-146 interleukin 1 beta Homo sapiens 5-9 26335060-1 2015 In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1beta) together with nitric oxide (NO) and superoxide anion (O2(-)). Superoxides 212-214 interleukin 1 beta Homo sapiens 148-156 26335060-2 2015 Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1beta is induced in microglia. Superoxides 40-42 interleukin 1 beta Homo sapiens 82-90 26335060-3 2015 The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction. Superoxides 194-196 interleukin 1 beta Homo sapiens 18-26 24721152-6 2014 But in the meantime, rhein enhances the activity of caspase-1 by inhibiting intracellular (in situ) IKKbeta, in turn increasing the IL-1beta and high-mobility-group box 1 release, which can be amplified by rhein s reductive effect on intracellular superoxide anion. Superoxides 248-264 interleukin 1 beta Homo sapiens 132-140 26391839-3 2015 The results obtained showed that exogenously-generated H2O2 induce anti-inflammatory and antioxidant effects in HUVECs counteracting the pro-inflammatory and pro-oxidant effect of IL-1beta related to the production of superoxide anions. Superoxides 218-235 interleukin 1 beta Homo sapiens 180-188 24101387-1 2013 Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS). Superoxides 58-82 interleukin 1 beta Homo sapiens 209-227 23918204-7 2013 One of the sources of ROS in IL-1beta-activated astrocytes was from increased superoxide production in mitochondria accompanied by enhanced manganese superoxide dismutase and inhibited catalase expression. Superoxides 78-88 interleukin 1 beta Homo sapiens 29-37 24101387-1 2013 Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS). Superoxides 58-82 interleukin 1 beta Homo sapiens 229-237 21211511-9 2011 These results provide strong pharmacological and genetic evidence for the implication of H-Ras and NADPH oxidase-generated superoxide production in MMP-13 gene regulation by IL-1beta and TNF-alpha. Superoxides 123-133 interleukin 1 beta Homo sapiens 174-182 17869312-3 2007 Superoxide production was quantified in synovial cells obtained from six patients with rheumatoid arthritis (RA) and six with osteoarthritis (OA), stimulated with (i) AA, and (ii) PLA(2) inhibitors prior to IL-1beta or TNF-alpha treatment. Superoxides 0-10 interleukin 1 beta Homo sapiens 207-215 18929641-2 2008 Interleukin-1beta, flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line (T84), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide-producing activity by ninefold. Superoxides 209-219 interleukin 1 beta Homo sapiens 0-17 18523309-6 2008 IL-1beta cleavage is blocked under conditions where superoxide anion formation is blocked or monocytes are treated with antioxidants or a peroxynitrite scavenger. Superoxides 52-68 interleukin 1 beta Homo sapiens 0-8 18378695-1 2008 The compartmentalized production of superoxide (*O(2)(-)) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation. Superoxides 36-46 interleukin 1 beta Homo sapiens 155-172 18378695-1 2008 The compartmentalized production of superoxide (*O(2)(-)) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation. Superoxides 36-46 interleukin 1 beta Homo sapiens 174-182 18785879-4 2009 Human CASMCs (coronary artery smooth muscle cells) in culture exposed to IL (interleukin)-1beta or TNF-alpha (tumour necrosis factor-alpha) had increased superoxide generation and enhanced CD40 expression, detected by EPR (electron paramagnetic resonance) and immunoblotting respectively. Superoxides 154-164 interleukin 1 beta Homo sapiens 73-95 18420487-7 2008 In marked contrast, exposure of HRECs to proinflammatory cytokines IL-1beta or TNF-alpha increased glucose consumption, mitochondrial superoxide production, ERK and JNK phosphorylation, tyrosine phosphorylation, NF-kappaB activation, and caspase activation. Superoxides 134-144 interleukin 1 beta Homo sapiens 67-75 15879116-5 2005 DMSO also elevated IL-1beta secretion by PBMC in response to exogenous superoxide anions. Superoxides 71-88 interleukin 1 beta Homo sapiens 19-27 17122966-0 2006 Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha. Superoxides 0-10 interleukin 1 beta Homo sapiens 101-118 17122966-1 2006 OBJECTIVES: to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production. Superoxides 73-89 interleukin 1 beta Homo sapiens 105-122 17122966-1 2006 OBJECTIVES: to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production. Superoxides 73-89 interleukin 1 beta Homo sapiens 124-132 16354686-4 2006 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated IL-1beta-dependent IKK and NF-kappaB activation. Superoxides 18-28 interleukin 1 beta Homo sapiens 100-108 16354686-6 2006 Small interfering RNAs to either MyD88 or Rac1 inhibited IL-1beta induction of endosomal superoxide and NF-kappaB activation. Superoxides 89-99 interleukin 1 beta Homo sapiens 57-65 14657615-3 2004 Therefore, the main objective of this study was to evaluate the effect of IL-1beta or NO on enzyme activity of NADPH oxidase (NOX), a superoxide-generating system recently documented to participate in a variety of vascular functions. Superoxides 134-144 interleukin 1 beta Homo sapiens 74-82 12034023-5 2002 Macrophage functions, such as production of superoxide anion and phagocytosis, also were stimulated by IL-1beta gene injection. Superoxides 44-60 interleukin 1 beta Homo sapiens 103-111 12101082-4 2002 In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH). Superoxides 150-166 interleukin 1 beta Homo sapiens 47-56 12466152-3 2003 In interleukin-1beta (IL-1beta)-stimulated hepatocytes exposed to superoxide, we demonstrate that hepatocyte nuclear factor-4alpha (HNF-4alpha) acts as an activator of redox-associated hepatocyte iNOS expression at the level of protein, mRNA, and promoter activation. Superoxides 66-76 interleukin 1 beta Homo sapiens 3-20 12466152-3 2003 In interleukin-1beta (IL-1beta)-stimulated hepatocytes exposed to superoxide, we demonstrate that hepatocyte nuclear factor-4alpha (HNF-4alpha) acts as an activator of redox-associated hepatocyte iNOS expression at the level of protein, mRNA, and promoter activation. Superoxides 66-76 interleukin 1 beta Homo sapiens 22-30 11358991-2 2001 Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood. Superoxides 76-86 interleukin 1 beta Homo sapiens 140-148 11698472-5 2001 IL-1beta primed neutrophils for enhanced release of superoxide (O(2)(-)) stimulated by FMLP in parallel with increased phosphorylation of p38 MAPK. Superoxides 52-62 interleukin 1 beta Homo sapiens 0-8 11698472-5 2001 IL-1beta primed neutrophils for enhanced release of superoxide (O(2)(-)) stimulated by FMLP in parallel with increased phosphorylation of p38 MAPK. Superoxides 64-68 interleukin 1 beta Homo sapiens 0-8 11509539-6 2001 Pretreatment of VSM cells with the NO donor DETA NONOate significantly (P < 0.05) decreased IL-1 beta-stimulated superoxide generation. Superoxides 116-126 interleukin 1 beta Homo sapiens 95-104 11509539-9 2001 We conclude that NO inhibits IL-1 beta-stimulated MMP-9 induction by inhibiting superoxide generation and subsequent ERK activation. Superoxides 80-90 interleukin 1 beta Homo sapiens 29-38 11709424-5 2001 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides 31-41 interleukin 1 beta Homo sapiens 0-9 11709424-5 2001 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides 119-129 interleukin 1 beta Homo sapiens 0-9 11709424-8 2001 The results demonstrate that IL-1 beta-dependent MMP-9 induction is mediated by superoxide-stimulated ERK activation. Superoxides 80-90 interleukin 1 beta Homo sapiens 29-38 11509539-5 2001 Stimulation of VSM cells with IL-1 beta significantly (P < 0.05) increased superoxide production, ERK activation, and MMP-9 induction. Superoxides 78-88 interleukin 1 beta Homo sapiens 30-39 10848817-6 2000 Cells in group B were appropriately primed by G-CSF, GM-CSF, tumour necrosis factor alpha and IL-1beta for enhanced release of O2 -. Superoxides 127-129 interleukin 1 beta Homo sapiens 94-102 10861792-5 2000 Our results indicate that exposure of pial and cerebral vasculature to IL-1 beta significantly accelerates recruitment of neutrophils, reduces cerebral blood flow, and increases superoxide anion concentration at the pial surface during reperfusion. Superoxides 178-194 interleukin 1 beta Homo sapiens 71-80 10861792-6 2000 These results support the idea that prior exposure of brain vasculature to IL-1 beta results in acceleration of cerebrovascular injury by accelerating recruitment of neutrophils, which secrete superoxide anion, during reperfusion. Superoxides 193-209 interleukin 1 beta Homo sapiens 75-84 10802230-1 2000 The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation. Superoxides 15-25 interleukin 1 beta Homo sapiens 125-142 10802230-1 2000 The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation. Superoxides 15-25 interleukin 1 beta Homo sapiens 144-152 10802230-1 2000 The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation. Superoxides 27-31 interleukin 1 beta Homo sapiens 125-142 10802230-1 2000 The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation. Superoxides 27-31 interleukin 1 beta Homo sapiens 144-152 10195945-4 1999 The reduction in superoxide and lipid oxidation by AT seemed to be mediated by inhibition of protein kinase C. The aim of this study was to investigate the mechanism(s) by which AT inhibits IL-1 beta release. Superoxides 17-27 interleukin 1 beta Homo sapiens 190-199 10666117-4 2000 Furthermore, superoxide production by IL-1beta, PDGF factor, and constitutively activated Ras is blocked by diphenyleneiodonium, implicating NAD(P)H oxidase as the generating enzyme. Superoxides 13-23 interleukin 1 beta Homo sapiens 38-46 10490275-0 1999 Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measurement. Superoxides 0-10 interleukin 1 beta Homo sapiens 24-38 10490279-8 1999 Under these conditions, superoxide production was enhanced with agonists, including interleukin-1beta, A23187, and phorbol 12-myristate 13-acetate. Superoxides 24-34 interleukin 1 beta Homo sapiens 84-101 10666117-2 2000 Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production. Superoxides 79-89 interleukin 1 beta Homo sapiens 18-26 10666117-2 2000 Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production. Superoxides 267-277 interleukin 1 beta Homo sapiens 18-26 9438552-3 1998 Superoxide production was increased more than twofold following preincubation with IL-1beta, or by the addition of the Ca2+ ionophore, Ionomycin. Superoxides 0-10 interleukin 1 beta Homo sapiens 83-91 8634411-3 1996 Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD). Superoxides 14-30 interleukin 1 beta Homo sapiens 146-154 8634411-3 1996 Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD). Superoxides 32-34 interleukin 1 beta Homo sapiens 146-154 8757337-6 1996 Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway. Superoxides 81-98 interleukin 1 beta Homo sapiens 45-54 8757337-6 1996 Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway. Superoxides 100-102 interleukin 1 beta Homo sapiens 45-54