PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19230846-6 2009 G6PD-derived NADPH increased (p < 0.05) superoxide anion levels by 70-90% in fa/fa vs lean rat liver, which was inhibited by the NADPH oxidase inhibitor gp91(ds-tat) (50 microM) and G6PD inhibitors 6-aminonicotinamide (1 mM) and dehydroepiandrosterone (100 microM), therefore indicating that elevated G6PD activity may be responsible for mediating superoxide generation. Superoxides 43-59 glucose-6-phosphate dehydrogenase Rattus norvegicus 0-4 19230846-6 2009 G6PD-derived NADPH increased (p < 0.05) superoxide anion levels by 70-90% in fa/fa vs lean rat liver, which was inhibited by the NADPH oxidase inhibitor gp91(ds-tat) (50 microM) and G6PD inhibitors 6-aminonicotinamide (1 mM) and dehydroepiandrosterone (100 microM), therefore indicating that elevated G6PD activity may be responsible for mediating superoxide generation. Superoxides 43-53 glucose-6-phosphate dehydrogenase Rattus norvegicus 0-4 25682169-7 2015 Neonatal hyperglycemic rats presented increased activities of G6PD, 6PGD, and Nox, which altogether may be responsible for the enhanced production of superoxide radical anion that was observed. Superoxides 150-174 glucose-6-phosphate dehydrogenase Rattus norvegicus 62-66 35623546-8 2022 Mechanistically, we found aorta of G6PDS188F as compared to WT rats produced less sustained contraction and less inositol-1,2,3-phosphate (IP3) and superoxide in response to Ang-II. Superoxides 148-158 glucose-6-phosphate dehydrogenase Rattus norvegicus 35-44 22580330-3 2012 Specifically knockdown of G6PD protein expression in hippocampus CA1 subregion at early reperfusion period (1-24 h) with a strategy to pre-treated G6PD AS-ODNs significantly reduced G6PD activity and NADPH level, an effect correlated with attenuation of NADPH oxidase activation and superoxide anion production. Superoxides 283-299 glucose-6-phosphate dehydrogenase Rattus norvegicus 26-30 22580330-3 2012 Specifically knockdown of G6PD protein expression in hippocampus CA1 subregion at early reperfusion period (1-24 h) with a strategy to pre-treated G6PD AS-ODNs significantly reduced G6PD activity and NADPH level, an effect correlated with attenuation of NADPH oxidase activation and superoxide anion production. Superoxides 283-299 glucose-6-phosphate dehydrogenase Rattus norvegicus 147-151 22580330-3 2012 Specifically knockdown of G6PD protein expression in hippocampus CA1 subregion at early reperfusion period (1-24 h) with a strategy to pre-treated G6PD AS-ODNs significantly reduced G6PD activity and NADPH level, an effect correlated with attenuation of NADPH oxidase activation and superoxide anion production. Superoxides 283-299 glucose-6-phosphate dehydrogenase Rattus norvegicus 147-151 19429815-3 2009 Our aim was to determine whether NADPH oxidase (Nox) is a source of O(2)(-) and whether glucose-6-phosphate dehydrogenase (G6PD)-derived NADPH plays a role in augmenting O(2)(-) generation in diabetes. Superoxides 170-174 glucose-6-phosphate dehydrogenase Rattus norvegicus 88-121 19429815-3 2009 Our aim was to determine whether NADPH oxidase (Nox) is a source of O(2)(-) and whether glucose-6-phosphate dehydrogenase (G6PD)-derived NADPH plays a role in augmenting O(2)(-) generation in diabetes. Superoxides 170-174 glucose-6-phosphate dehydrogenase Rattus norvegicus 123-127 19429815-10 2009 Our findings suggest that in a model of severe hyperlipidema and hyperglycemia Nox-derived O(2)(-) generation in the myocardium is fueled by elevated levels of G6PD-derived NADPH. Superoxides 91-95 glucose-6-phosphate dehydrogenase Rattus norvegicus 160-164