PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8901022-6	1996	An IP3 receptor antagonist, heparin, reduced both the substance P-induced O2- production and the transient increase in [Ca2+]i without any significant effects on the sustained increase in [Ca2+]i.	Superoxides	74-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	3-15	
8957234-7	1996	We concluded that CGRP receptor stimulation reduces substance-P-induced O2- production by the inhibition of IP3-induced transient increase in [Ca2+]i, probably via the phosphorylation of IP3 receptor by cAMP-dependent protein kinase.	Superoxides	72-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	187-199	
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	Superoxides	106-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244	
24747490-7	2014	Nevertheless, a phospholipase C (PLC) inhibitor and an inositol triphosphate (IP3) receptor antagonist considerably suppressed ugonin U-stimulated Ca(2+) mobilization and subsequent superoxide release.	Superoxides	182-192	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-91