PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1468117-3 1992 Both GH and IFN-gamma primed macrophages triggered with opsonized zymosan to secrete superoxide anion (O2-) in vitro, but IFN-gamma was effective at a 40-fold lower concentration. Superoxides 85-101 gonadotropin releasing hormone receptor Rattus norvegicus 5-7 8262614-0 1994 Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone. Superoxides 13-29 gonadotropin releasing hormone receptor Rattus norvegicus 149-163 8262614-2 1994 Secretion of O2- and killing of E. coli by PMN from both young and old rats can be significantly augmented by preincubation with either 250 U of gamma interferon (IFN-gamma) or 250 ng of growth hormone (GH) per ml. Superoxides 13-15 gonadotropin releasing hormone receptor Rattus norvegicus 187-201 8262614-2 1994 Secretion of O2- and killing of E. coli by PMN from both young and old rats can be significantly augmented by preincubation with either 250 U of gamma interferon (IFN-gamma) or 250 ng of growth hormone (GH) per ml. Superoxides 13-15 gonadotropin releasing hormone receptor Rattus norvegicus 203-205 8262614-3 1994 This priming is specific, because neutralizing monoclonal antibodies against either IFN-gamma or GH completely abrogate the enhanced O2- secretion by PMN from young rats. Superoxides 133-135 gonadotropin releasing hormone receptor Rattus norvegicus 97-99 1468117-3 1992 Both GH and IFN-gamma primed macrophages triggered with opsonized zymosan to secrete superoxide anion (O2-) in vitro, but IFN-gamma was effective at a 40-fold lower concentration. Superoxides 103-105 gonadotropin releasing hormone receptor Rattus norvegicus 5-7 1316877-2 1992 Macrophages obtained from rats with intact pituitaries (pituitary-intact rats) or HX rats that were treated in vivo with either GH or the closely related hormone prolactin released elevated (P less than 0.05) levels of superoxide anion (O2-) after in vitro opsonized-zymosan stimulation compared with those from placebo-treated animals. Superoxides 219-235 gonadotropin releasing hormone receptor Rattus norvegicus 128-130 1316877-2 1992 Macrophages obtained from rats with intact pituitaries (pituitary-intact rats) or HX rats that were treated in vivo with either GH or the closely related hormone prolactin released elevated (P less than 0.05) levels of superoxide anion (O2-) after in vitro opsonized-zymosan stimulation compared with those from placebo-treated animals. Superoxides 237-239 gonadotropin releasing hormone receptor Rattus norvegicus 128-130 1316877-4 1992 In time course in vivo macrophage activation studies, both IFN-gamma and GH significantly increased O2- secretion within 24 h, with maximal secretion occurring at day 3. Superoxides 100-102 gonadotropin releasing hormone receptor Rattus norvegicus 73-75 1316877-6 1992 The mechanism of action of GH in vivo is likely to be a direct one because resident peritoneal macrophages from rats could be primed in vitro for enhanced secretion of O2- following triggering of these cells with opsonized zymosan. Superoxides 168-170 gonadotropin releasing hormone receptor Rattus norvegicus 27-29