PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8007817-3 1993 The activation by IFN gamma and/or infection with MHV3 showed that BALB/c mouse macrophages were capable of releasing tumor necrosis factor alpha (TNF alpha), interleukin 1 (IL-1) and anion superoxide (O2-), and A/J mouse macrophages were capable of releasing TNF alpha and IL-1 but not O2-. Superoxides 287-289 interferon gamma Mus musculus 18-27 8125136-2 1994 We now show that murine macrophages activated with zymosan and interferon-gamma (ZYM/IFN-gamma) produced both superoxide (peaking 1-2 h after stimulation, then rapidly declining) and NO (barely detectable at 6 h, peaking by 24 h). Superoxides 110-120 interferon gamma Mus musculus 63-79 8125136-2 1994 We now show that murine macrophages activated with zymosan and interferon-gamma (ZYM/IFN-gamma) produced both superoxide (peaking 1-2 h after stimulation, then rapidly declining) and NO (barely detectable at 6 h, peaking by 24 h). Superoxides 110-120 interferon gamma Mus musculus 85-94 8125136-3 1994 Macrophages activated with ZYM alone produced only superoxide, while stimulation with lipopolysaccharide (LPS) and IFN-gamma induced NO but not superoxide. Superoxides 144-154 interferon gamma Mus musculus 115-124 8007817-3 1993 The activation by IFN gamma and/or infection with MHV3 showed that BALB/c mouse macrophages were capable of releasing tumor necrosis factor alpha (TNF alpha), interleukin 1 (IL-1) and anion superoxide (O2-), and A/J mouse macrophages were capable of releasing TNF alpha and IL-1 but not O2-. Superoxides 190-200 interferon gamma Mus musculus 18-27 8007817-3 1993 The activation by IFN gamma and/or infection with MHV3 showed that BALB/c mouse macrophages were capable of releasing tumor necrosis factor alpha (TNF alpha), interleukin 1 (IL-1) and anion superoxide (O2-), and A/J mouse macrophages were capable of releasing TNF alpha and IL-1 but not O2-. Superoxides 202-204 interferon gamma Mus musculus 18-27 8409451-4 1993 The cytokine IFN-gamma triggered activation of these macrophages and down-regulated cell surface expression of the mannose receptor after 48 h. Macrophage activation, as assessed by the generation of superoxide radicals, was inversely correlated with mannose receptor expression. Superoxides 200-210 interferon gamma Mus musculus 13-22 1328038-4 1992 We found that IL-4 could inhibit the priming of macrophages for enhanced superoxide production induced by IFN-gamma although IL-4 when used alone did have some enhancing effect of its own. Superoxides 73-83 interferon gamma Mus musculus 106-115 1328038-5 1992 This effect of IL-4 on IFN-gamma-primed superoxide production was dose dependent and could be observed even if the treatment by IL-4 was done 24 hr after treatment by IFN-gamma. Superoxides 40-50 interferon gamma Mus musculus 23-32 1328038-5 1992 This effect of IL-4 on IFN-gamma-primed superoxide production was dose dependent and could be observed even if the treatment by IL-4 was done 24 hr after treatment by IFN-gamma. Superoxides 40-50 interferon gamma Mus musculus 167-176 1769697-6 1991 The macrophages released more superoxide (O2-), TNF and interleukin-1 (IL-1) on LPS triggering, and the releases of these compounds were further increased by addition of recombinant interferon-gamma (IFN-gamma) to the medium. Superoxides 30-40 interferon gamma Mus musculus 182-198 1310262-5 1992 Priming in vitro by interferon (IFN)-gamma for enhanced release of O2- was also significantly impaired in protein-deprived mice. Superoxides 67-69 interferon gamma Mus musculus 20-42 1769697-6 1991 The macrophages released more superoxide (O2-), TNF and interleukin-1 (IL-1) on LPS triggering, and the releases of these compounds were further increased by addition of recombinant interferon-gamma (IFN-gamma) to the medium. Superoxides 42-44 interferon gamma Mus musculus 182-198 1646910-5 1991 In a separate study (n = 100 mice), IFN-gamma (1000-10,000 U/day ip) vs saline was given for 3 days prior to harvesting peritoneal macrophages for assay of superoxide anion (O2-), percentage macrophage phagocytosis of C. albicans, and percentage killing of C. albicans. Superoxides 156-172 interferon gamma Mus musculus 36-45 1646910-5 1991 In a separate study (n = 100 mice), IFN-gamma (1000-10,000 U/day ip) vs saline was given for 3 days prior to harvesting peritoneal macrophages for assay of superoxide anion (O2-), percentage macrophage phagocytosis of C. albicans, and percentage killing of C. albicans. Superoxides 174-176 interferon gamma Mus musculus 36-45 1847038-6 1991 In another group of mice, we evaluated the ability of interferon gamma to up-regulate superoxide anion release and Candida phagocytosis and killing. Superoxides 86-102 interferon gamma Mus musculus 54-70 1847038-8 1991 Superoxide anion production in resident and activated (lipopolysaccharide, interferon gamma, bacille Calmette-Guerin infection) peritoneal macrophages was significantly reduced in the malnourished group. Superoxides 0-16 interferon gamma Mus musculus 75-91 2155263-10 1990 Other functional studies showed that they were primed for the secretion of superoxide ion and could be stimulated in vitro by IFN-gamma and LPS to lyse tumor target cells. Superoxides 75-85 interferon gamma Mus musculus 126-135 26269022-3 2015 Our laboratory recently demonstrated that superoxide-deficient nonobese diabetic (NOD.Ncf1(m1J)) mice exhibited a delay in type 1 diabetes (T1D) partially due to blunted IFN-gamma synthesis by CD4 T cells. Superoxides 42-52 interferon gamma Mus musculus 170-179 27585756-5 2016 Our results showed that in the LPS/IFNgamma-activated microglia TQ significantly decreased the cellular production of both superoxide and nitric oxide fourfold (p < 0.0001) and sixfold (p < 0.0001), respectfully. Superoxides 123-133 interferon gamma Mus musculus 35-43 2550367-7 1989 Enhanced fungicidal activity by PB-PMNs from mice treated for 5 h with 25,000 U of IFN correlated with an increased release of superoxide anion (O2-) in vitro after stimulation of PB-PMNs with phorbol ester; normal PB-PMNs and IFN-activated PB-PMNs, respectively, produced 2.2 +/- 2.5 and 23.5 +/- 4.8 nmol of O2- per 10(6) PB-PMNs per 30 min (P less than 0.005). Superoxides 127-143 interferon gamma Mus musculus 83-86 2550367-7 1989 Enhanced fungicidal activity by PB-PMNs from mice treated for 5 h with 25,000 U of IFN correlated with an increased release of superoxide anion (O2-) in vitro after stimulation of PB-PMNs with phorbol ester; normal PB-PMNs and IFN-activated PB-PMNs, respectively, produced 2.2 +/- 2.5 and 23.5 +/- 4.8 nmol of O2- per 10(6) PB-PMNs per 30 min (P less than 0.005). Superoxides 127-143 interferon gamma Mus musculus 227-230 2550367-7 1989 Enhanced fungicidal activity by PB-PMNs from mice treated for 5 h with 25,000 U of IFN correlated with an increased release of superoxide anion (O2-) in vitro after stimulation of PB-PMNs with phorbol ester; normal PB-PMNs and IFN-activated PB-PMNs, respectively, produced 2.2 +/- 2.5 and 23.5 +/- 4.8 nmol of O2- per 10(6) PB-PMNs per 30 min (P less than 0.005). Superoxides 145-147 interferon gamma Mus musculus 83-86 2550367-7 1989 Enhanced fungicidal activity by PB-PMNs from mice treated for 5 h with 25,000 U of IFN correlated with an increased release of superoxide anion (O2-) in vitro after stimulation of PB-PMNs with phorbol ester; normal PB-PMNs and IFN-activated PB-PMNs, respectively, produced 2.2 +/- 2.5 and 23.5 +/- 4.8 nmol of O2- per 10(6) PB-PMNs per 30 min (P less than 0.005). Superoxides 145-147 interferon gamma Mus musculus 227-230 2538510-3 1989 However, the ability to generate O2- in response to PMA could be induced in BMM by pre-exposing the cells to certain cytokines, including granulocyte-macrophage CSF (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), IFN-gamma, and, to a lesser extent, IL-1 alpha. Superoxides 33-35 interferon gamma Mus musculus 216-225 2417944-3 1985 These studies show that IFN gamma, but not IFN alpha beta, induce an activation phenotype (low mannose fucosyl receptor levels, high Ia, high superoxide release) in bone marrow macrophages. Superoxides 142-152 interferon gamma Mus musculus 24-33 27467924-7 2016 Mechanistic investigations revealed that nitric oxide (NO), superoxide and peroxynitrite produced by uncoupling of inducible NO synthase (NOS II) in cancer cells are key mediators of ALA and IFNgamma-mediated tumor growth inhibition. Superoxides 60-70 interferon gamma Mus musculus 191-199 21826531-8 2011 Superoxide production was higher in both MAT and SMA of Lepr(db) mice, and anti-IFNgamma reduced MAT and SMA superoxide production. Superoxides 109-119 interferon gamma Mus musculus 80-88 24368122-4 2014 These stimuli can also induce IFN-gamma-pretreated neutrophils to release reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide and hypochlorous acid, as well as granule lysosomal enzymes and the pro-inflammatory cytokines TNF-alpha and IL-6. Superoxides 113-129 interferon gamma Mus musculus 30-39 23520167-4 2013 Absence of T-box expressed in T cells (T-bet), the IFN-gamma transcription factor encoded by Tbx21, reduced vascular superoxide and peroxynitrite formation and attenuated expression of nicotinamide adenosine dinucleotide phosphate oxidase subunits as well as inducible NO synthase, monocyte chemoattractant protein 1, and interleukin-12 in aortas of ATII-infused mice. Superoxides 117-127 interferon gamma Mus musculus 51-60 24281189-9 2014 Furthermore, interferon-gamma neutralization eliminates AngII-increased superoxide products and endothelial apoptosis by inhibiting AngII-induced Kynurenines generation, suggesting that AngII-activated Kyn pathway is interferon-gamma-dependent. Superoxides 72-82 interferon gamma Mus musculus 13-29 19684141-6 2009 Transcomplementing the sodC gene in the DeltasodC mutant or inhibiting the IFN-gamma-dependent production of O(2)(-) or nitric oxide (NO) enhanced intramacrophage survival of the sod mutants. Superoxides 109-116 interferon gamma Mus musculus 75-84 20511543-2 2010 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Superoxides 43-47 interferon gamma Mus musculus 61-77 20511543-2 2010 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Superoxides 43-47 interferon gamma Mus musculus 79-87 18791203-4 2009 LPS + IFN gamma increased synthesis of peroxynitrite precursors nitric oxide (NO) and superoxide by inducible NO synthase (iNOS) and NADPH oxidase, respectively. Superoxides 86-96 interferon gamma Mus musculus 6-15 19508391-4 2009 KEY RESULTS: LPS + IFNgamma caused an increase in monolayer permeability, induction of iNOS and NADPH oxidase type 1 (Nox1) proteins, formation of superoxide, nitric oxide and 3-nitrotyrosine, and increase in PP2A activity in endothelial cells. Superoxides 147-157 interferon gamma Mus musculus 19-27 18791203-8 2009 CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation. Superoxides 110-120 interferon gamma Mus musculus 18-27 15788155-3 2005 Murine IFN-gamma-activated peritoneal exudate cells (PEC) produced nitric oxide (NO), measured as nitrite plus nitrate, and superoxide. Superoxides 124-134 interferon gamma Mus musculus 7-16 17530864-2 2007 Stimulation with a soluble agonist or activation with bacterial lipopolysaccharide plus gamma-interferon caused only very small initial increases in O2 consumption above basal rates; however, at 2-4 h post-activation, respiration increased to 2-3-fold and remained at these elevated levels over the subsequent lifetime of the cell (20-30 h). Superoxides 149-151 interferon gamma Mus musculus 88-104 18408127-8 2008 These findings implicate the immune system in the early endothelial cell dysfunction associated with hypercholesterolemia and are consistent with a mechanism of impaired EDV that is mediated by CD4+ T cells and IFN-gamma, acting through the generation of superoxide from vascular NAD(P)H oxidase. Superoxides 255-265 interferon gamma Mus musculus 211-220 11016629-5 2000 NO and superoxide (O2-) generation was induced by a combination of lipopolysaccharide and IFN-gamma in mouse macrophage RAW 264.7 cells, and by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocyte HL-60, respectively. Superoxides 7-17 interferon gamma Mus musculus 90-99 12584172-5 2003 RAW 264.7 cells stimulated with LPS and IFN-gamma produced O(2)(-), nitric oxide (NO) and peroxynitrite (ONOO(-)) continuously for 5-25 h. There was a 2.0-fold increase in the mutation frequency of the gpt gene in AS52 cells co-cultured with TPA stimulated HL-60 cells, when compared with non-treated cells. Superoxides 59-63 interferon gamma Mus musculus 40-49 11159984-4 2001 IFN-gamma-activated resting peritoneal macrophages from MIF(-/-) mice showed impaired macrophage leishmanicidal activity and produced significantly lower levels of nitric oxide and superoxide in vitro. Superoxides 181-191 interferon gamma Mus musculus 0-9 11168643-4 2001 Phorbol 12-myristate 13-acetate (PMA)-stimulated and interferon-gamma (IFN-gamma)-induced superoxide formation was enhanced in peritoneal Mphi lacking TRAP; nitrite production in response to stimulation with lipopolysaccharide (LPS) and IFN-gamma was also increased. Superoxides 90-100 interferon gamma Mus musculus 0-80 11168643-4 2001 Phorbol 12-myristate 13-acetate (PMA)-stimulated and interferon-gamma (IFN-gamma)-induced superoxide formation was enhanced in peritoneal Mphi lacking TRAP; nitrite production in response to stimulation with lipopolysaccharide (LPS) and IFN-gamma was also increased. Superoxides 90-100 interferon gamma Mus musculus 71-80 11474120-9 2000 The concomitant stimulation of the FcyR and the translocation of the SOD1 in the cytoplasm of IFN-gamma-activated macrophages not only reduced the production of superoxide anion but also induced the expression of the inducible form of nitric oxide synthase (iNOS) and the related NO production. Superoxides 161-177 interferon gamma Mus musculus 94-103 11016629-5 2000 NO and superoxide (O2-) generation was induced by a combination of lipopolysaccharide and IFN-gamma in mouse macrophage RAW 264.7 cells, and by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocyte HL-60, respectively. Superoxides 19-21 interferon gamma Mus musculus 90-99 10624880-4 1999 simpliciflora root, a traditional medicine as an antipyretic, modulates the generation of NO and superoxide in IFN-gamma primed or polymyristic acetate (PMA) stimulated RAW 264.7 cells, respectively. Superoxides 97-107 interferon gamma Mus musculus 111-120 10944420-7 2000 IFN-gamma increased superoxide and thiol productions in both types of macrophages. Superoxides 20-30 interferon gamma Mus musculus 0-9 10944420-8 2000 We conclude that IFN-gamma promotes macrophage-mediated LDL oxidation by stimulating superoxide and thiol production under conditions where iNOS-catalyzed NO release is restricted. Superoxides 85-95 interferon gamma Mus musculus 17-26 9159493-3 1997 After inducing the endogenous NO production with interleukin 1beta (IL-1beta) and interferon-gamma (IFN-gamma) the superoxide anion release was significantly reduced, which was reversed by the inhibition of the NO synthase. Superoxides 115-131 interferon gamma Mus musculus 82-98 9159493-3 1997 After inducing the endogenous NO production with interleukin 1beta (IL-1beta) and interferon-gamma (IFN-gamma) the superoxide anion release was significantly reduced, which was reversed by the inhibition of the NO synthase. Superoxides 115-131 interferon gamma Mus musculus 100-109 8954615-3 1996 Pretreatment of murine peritoneal macrophages with either LPS or IFN-gamma suppressed macrophage responsiveness to both PAF-induced calcium mobilization and superoxide anion (O2-) production. Superoxides 157-173 interferon gamma Mus musculus 65-74 8954615-3 1996 Pretreatment of murine peritoneal macrophages with either LPS or IFN-gamma suppressed macrophage responsiveness to both PAF-induced calcium mobilization and superoxide anion (O2-) production. Superoxides 175-177 interferon gamma Mus musculus 65-74 8954615-7 1996 LPS and IFN-gamma treatment also decreased PAF-induced, calcium-dependent O2- production. Superoxides 74-76 interferon gamma Mus musculus 8-17 8954615-8 1996 When added together, IFN-gamma increased the suppression of PAF-induced intracellular calcium mobilization and inhibited O2- production mediated by LPS. Superoxides 121-123 interferon gamma Mus musculus 21-30 8658499-5 1996 Total hydrogen peroxide and superoxide production was increased by stimulation of IFN gamma-primed cells with zymosan, but relative increases in primed V-treated cells were lower than that in controls. Superoxides 28-38 interferon gamma Mus musculus 82-91 8943420-3 1996 Incubation of peritoneal exudate macrophages with LPS and IFN-gamma significantly inhibited the production of elastase by a mechanism independent of nitric oxide, superoxide, and hydrogen peroxide. Superoxides 163-173 interferon gamma Mus musculus 58-67 9157782-5 1996 Interferon (IFN) gamma, a stimulant of NADPH oxidase activity, increased superoxide production and bone resorption in cultures of calvarial explants from osteopetrotic (microphthalmic) mice. Superoxides 73-83 interferon gamma Mus musculus 0-22 7751055-6 1995 We also found that IFN-gamma and TNF-alpha stimulated the release of bioactive TGF-beta and that treatment of microglial cell cultures with TGF-beta antagonized the priming effects of IFN-gamma and TNF-alpha on O2- production. Superoxides 211-213 interferon gamma Mus musculus 19-28 7751055-6 1995 We also found that IFN-gamma and TNF-alpha stimulated the release of bioactive TGF-beta and that treatment of microglial cell cultures with TGF-beta antagonized the priming effects of IFN-gamma and TNF-alpha on O2- production. Superoxides 211-213 interferon gamma Mus musculus 184-193