PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29183727-1 2018 The membrane bound cytochrome b558 composed of gp91-phox and p22-phox proteins, and cytosolic proteins p40-, p47-and p67-phox are important components of superoxide (O2-)-generating system in phagocytes. Superoxides 154-164 interleukin 9 Homo sapiens 103-106 29183727-1 2018 The membrane bound cytochrome b558 composed of gp91-phox and p22-phox proteins, and cytosolic proteins p40-, p47-and p67-phox are important components of superoxide (O2-)-generating system in phagocytes. Superoxides 166-168 interleukin 9 Homo sapiens 103-106 25699251-1 2015 The superoxide (O( -) 2)-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b 558 (a heterodimer of Nox2 and p22 (phox) ), and four cytosolic components, p47 (phox) , p67 (phox) , p40 (phox) , and Rac. Superoxides 4-14 interleukin 9 Homo sapiens 213-216 24504963-1 2014 The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac. Superoxides 4-14 interleukin 9 Homo sapiens 262-265 20346917-1 2010 The membrane bound cytochrome b558 composed of large gp91-phox and small p22-phox subunits, and cytosolic proteins p40-, p47- and p67-phox are important components of superoxide (O(2)(-))-generating system in phagocytes and B lymphocytes. Superoxides 167-177 interleukin 9 Homo sapiens 115-118 20817944-1 2010 The assembly of cytosolic subunits p47(phox), p67(phox), and p40(phox) with flavocytochrome b(558) at the membrane is required for activating the neutrophil NADPH oxidase that generates superoxide for microbial killing. Superoxides 186-196 interleukin 9 Homo sapiens 61-64 20529851-1 2010 The superoxide-generating NADPH oxidase complex of resting phagocytes includes cytochrome b(559), a membrane-associated heterodimer composed of two subunits (Nox2 and p22(phox)), and four cytosolic proteins (p47(phox), p67(phox), Rac, and p40(phox)). Superoxides 4-14 interleukin 9 Homo sapiens 239-242 20346917-1 2010 The membrane bound cytochrome b558 composed of large gp91-phox and small p22-phox subunits, and cytosolic proteins p40-, p47- and p67-phox are important components of superoxide (O(2)(-))-generating system in phagocytes and B lymphocytes. Superoxides 179-182 interleukin 9 Homo sapiens 115-118 18711001-1 2008 The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b(558) and cytosolic p67(phox), p47(phox), and p40(phox) subunits that undergo membrane translocation upon cellular activation. Superoxides 38-48 interleukin 9 Homo sapiens 165-168 19692703-3 2009 A fifth subunit, p40(phox), plays an important role in phagocytosis-induced superoxide production via a phox homology (PX) domain that binds to phosphatidylinositol 3-phosphate (PtdIns(3)P). Superoxides 76-86 interleukin 9 Homo sapiens 17-20 20375610-2 2009 In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary complex with p47(phox)and p40(phox), and interacts with the small GTPase Rac to assemble with the membrane-integrated catalytic protein gp91(phox), leading to superoxide production. Superoxides 289-299 interleukin 9 Homo sapiens 156-159 18711001-3 2008 Recent studies showed that phagocytosis-induced superoxide production is stimulated by p40(phox) and its binding to phosphatidylinositol-3-phosphate (PI3P), a phosphoinositide enriched in membranes of internalized phagosomes. Superoxides 48-58 interleukin 9 Homo sapiens 87-90 18711001-8 2008 We conclude that p40(phox) functions primarily to regulate FcgammaR-induced NADPH oxidase activity rather than assembly, and stimulates superoxide production via a PI3P signal that increases after phagosome internalization. Superoxides 136-146 interleukin 9 Homo sapiens 17-20 11733522-1 2002 The superoxide-generating NADPH oxidase complex of phagocytes consists of a membranal heterodimeric flavocytochrome (cytochrome b(559)), composed of gp91(phox) and p22(phox) subunits, and four cytosolic proteins, p47(phox), p67(phox), p40(phox), and the small GTPase Rac (1 or 2). Superoxides 4-14 interleukin 9 Homo sapiens 235-238 18807499-0 2008 [Crystal structure of p40(phox) and regulation mechanism of superoxide generation]. Superoxides 60-70 interleukin 9 Homo sapiens 22-25 12456638-0 2002 The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase. Superoxides 61-71 interleukin 9 Homo sapiens 20-23 12456638-4 2002 Here we show that p40(phox) enhances membrane translocation of p67(phox) and p47(phox) in stimulated cells, which leads to facilitated production of superoxide. Superoxides 149-159 interleukin 9 Homo sapiens 18-21 11007780-1 2000 The superoxide (O(2))-generating NADPH oxidase complex of phagocytes consists of a membrane-associated flavocytochrome (cytochrome b(559)) and four cytosolic proteins, p47(phox), p67(phox), p40(phox), and the small GTPase Rac (Rac1 or -2). Superoxides 4-14 interleukin 9 Homo sapiens 190-193 11007780-1 2000 The superoxide (O(2))-generating NADPH oxidase complex of phagocytes consists of a membrane-associated flavocytochrome (cytochrome b(559)) and four cytosolic proteins, p47(phox), p67(phox), p40(phox), and the small GTPase Rac (Rac1 or -2). Superoxides 16-20 interleukin 9 Homo sapiens 190-193 9624128-1 1998 The superoxide generating NADPH oxidase of phagocytes consists, in resting cells, of a membrane-associated electron transporting flavocytochrome (cytochrome b559) and four cytosolic proteins as follows: p47(phox), p67(phox), p40(phox), and the small GTPase, Rac(1 or 2). Superoxides 4-14 interleukin 9 Homo sapiens 225-228 9804763-2 1998 The superoxide-generating NADPH oxidase complex of phagocytic cells is a multicomponent system containing a membrane-bound flavocytochrome b and a small G protein Rac as well as cytosolic factors p67(phox) (phagocyte oxidase), p47(phox), and p40(phox), which translocate to the membrane upon activation. Superoxides 4-14 interleukin 9 Homo sapiens 242-245 9804763-3 1998 In a previous paper, we reported that p40(phox) undergoes phosphorylation on multiple sites upon stimulation of the NADPH oxidase by either phorbol 12-myristate 13-acetate or by formyl peptide with a time course that is strongly correlated with that of superoxide production (Fuchs, A., Bouin, A. P., Rabilloud, T., and Vignais, P. V. (1997) Eur. Superoxides 253-263 interleukin 9 Homo sapiens 38-41 8663333-2 1996 During activation, cytosolic proteins p47(phox), p67(phox), Rac2, and possibly p40(phox) translocate to the plasma membrane and associate with flavocytochrome b to form the active superoxide-generating system. Superoxides 180-190 interleukin 9 Homo sapiens 79-82 3017990-2 1986 We have utilized monoclonal antibodies against the two IgG Fc receptors (p40 and p72) of U937 cells to stimulate the release of superoxide. Superoxides 128-138 interleukin 9 Homo sapiens 73-76