PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11491650-3 2001 Here we demonstrate that overexpression of MnSOD enhances the activity of the superoxide (O2*-)-sensitive enzyme aconitase, decreases the intracellular GSH/GSSG ratio, and dose-dependently inhibits pyruvate carboxylase activity. Superoxides 78-88 superoxide dismutase 2 Homo sapiens 43-48 11491650-3 2001 Here we demonstrate that overexpression of MnSOD enhances the activity of the superoxide (O2*-)-sensitive enzyme aconitase, decreases the intracellular GSH/GSSG ratio, and dose-dependently inhibits pyruvate carboxylase activity. Superoxides 90-92 superoxide dismutase 2 Homo sapiens 43-48 11491650-4 2001 Thus, alterations in the steady-state concentrations of mitochondrial O2*- and H2O2 as a result of MnSOD overexpression can alter the metabolic capacity of the cell leading to inhibition of cell growth. Superoxides 70-73 superoxide dismutase 2 Homo sapiens 99-104 11491650-5 2001 Furthermore, we propose that MnSOD overexpression can modulate the activity of nitric oxide (*NO) by preventing its reaction with O2*-. Superoxides 130-134 superoxide dismutase 2 Homo sapiens 29-34 23045062-3 2001 As described in this unit, this activity can be measured indirectly based on competition between SOD and an indicator molecule that reacts avidly with superoxide to produce a measurable change in absorption, thus it is possible to measure total SOD activity or that of CuZn-SOD and MnSOD. Superoxides 151-161 superoxide dismutase 2 Homo sapiens 97-100 23045062-3 2001 As described in this unit, this activity can be measured indirectly based on competition between SOD and an indicator molecule that reacts avidly with superoxide to produce a measurable change in absorption, thus it is possible to measure total SOD activity or that of CuZn-SOD and MnSOD. Superoxides 151-161 superoxide dismutase 2 Homo sapiens 245-248 23045062-3 2001 As described in this unit, this activity can be measured indirectly based on competition between SOD and an indicator molecule that reacts avidly with superoxide to produce a measurable change in absorption, thus it is possible to measure total SOD activity or that of CuZn-SOD and MnSOD. Superoxides 151-161 superoxide dismutase 2 Homo sapiens 282-287 11328670-12 2001 Tyrosine nitration and inactivation of MnSOD would lead to increased levels of superoxide and concomitant increases in ONOO- within the mitochondria which, could lead to tyrosine nitration/oxidation of key mitochondrial proteins and ultimately mitochondrial dysfunction and cell death. Superoxides 79-89 superoxide dismutase 2 Homo sapiens 39-44 11159050-4 2001 Hypoxia (1% O2) inhibited the production of superoxide (O2-) and the induction of MnSOD, but not TNF-alpha, mRNA. Superoxides 12-14 superoxide dismutase 2 Homo sapiens 82-87 10924720-10 2000 The findings suggest that large changes in the SOD isoenzymes might occur in vascular diseases, significantly altering the susceptibility of the vascular wall to adverse effects of the superoxide radical. Superoxides 185-195 superoxide dismutase 2 Homo sapiens 47-50 10962132-6 2000 Increased SOD-activities in the mitochondria could lower the superoxide concentration in this organelle and may prevent an oxidative and/or nitrosative damage via a decreased peroxynitrite formation. Superoxides 61-71 superoxide dismutase 2 Homo sapiens 10-13 11053990-7 2000 Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Superoxides 199-209 superoxide dismutase 2 Homo sapiens 156-162 10889449-5 2000 Taken together, these observations suggest that the induction of MnSOD expression by TNF-alpha is at least partially mediated by intracellular formation of oxygen free radicals, and that superoxide is most likely the initiating species involved in the mediation of MnSOD gene expression by TNF-alpha. Superoxides 187-197 superoxide dismutase 2 Homo sapiens 265-270 10919671-1 2000 Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix. Superoxides 107-125 superoxide dismutase 2 Homo sapiens 0-41 10919671-1 2000 Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix. Superoxides 107-125 superoxide dismutase 2 Homo sapiens 43-48 10644010-5 1999 Our results show a 20-50% increase in both SOD activities when cells were exposed to TNF or to an oxidative stress produced by Paraquat (a generator of superoxide anion radicals), both in terms of enzymes activity (zymogram) and protein levels (Western blotting and ELISA). Superoxides 152-177 superoxide dismutase 2 Homo sapiens 43-46 10644478-1 2000 BACKGROUND: Manganese superoxide dismutase (MnSOD) catalyzes the scavenging of superoxide radicals in order to protect cells from the damage caused by reactive oxygen species. Superoxides 22-32 superoxide dismutase 2 Homo sapiens 44-49 10455106-6 1999 This study shows that the inhibited complex responsible for the zero-order phase in the catalysis by Mn-SOD of superoxide dismutation can be reached through both the forward (O-(2)) and reverse (H(2)O(2)) reactions, supporting a mechanism in which the zero-order phase results from product inhibition. Superoxides 111-121 superoxide dismutase 2 Homo sapiens 101-107 10529750-7 1999 The results suggest that mutations influencing the cellular allocation of Mn-SOD may be a risk factor in MND, especially in females, and that MND may be a disease of misdistribution of the superoxide dismutase enzymes. Superoxides 189-199 superoxide dismutase 2 Homo sapiens 74-80 10512624-2 1999 We have made a mutant containing the conservative replacement Trp 161 --> Phe in human MnSOD (W161F MnSOD), determined its crystal structure, and measured the catalysis of the resulting mutant using pulse radiolysis to produce O(2)(*)(-). Superoxides 230-234 superoxide dismutase 2 Homo sapiens 90-95 10480957-1 1999 OBJECTIVES: to assess the efficacy of recombinant human manganese superoxide dismutase (rhMnSOD) in prevention of early and late skeletal muscle ischaemia-reperfusion injury mediated by superoxide (O2-). Superoxides 198-200 superoxide dismutase 2 Homo sapiens 56-86 10511315-1 1999 The overexpression of manganese superoxide dismutase (MnSOD), an enzyme that catalyzes the removal of superoxide (O2*-) from the mitochondria, has been shown to be closely associated with tumor regression in vivo and loss of the malignant phenotype in vitro. Superoxides 32-42 superoxide dismutase 2 Homo sapiens 54-59 9920876-1 1999 Mitochondrial manganese superoxide dismutase (Mn-SOD) is the primary cellular defense against damaging superoxide radicals generated by aerobic metabolism and as a consequence of inflammatory disease. Superoxides 24-34 superoxide dismutase 2 Homo sapiens 46-52 11225732-8 1999 The use of mitochondrial superoxide dismutase (MnSOD), which degrades superoxides arising from ischemia/reperfusion injury, is one example of this approach. Superoxides 70-81 superoxide dismutase 2 Homo sapiens 11-45 11225732-8 1999 The use of mitochondrial superoxide dismutase (MnSOD), which degrades superoxides arising from ischemia/reperfusion injury, is one example of this approach. Superoxides 70-81 superoxide dismutase 2 Homo sapiens 47-52 9925760-3 1999 It was found that superoxide produced by hyperoxic culture conditions (95% O2 atm) or the redox cycling agent paraquat caused a lesion of the import/processing of precursor hMn-SOD in the baculovirus model. Superoxides 18-28 superoxide dismutase 2 Homo sapiens 173-180 9700139-2 1998 In this study we investigated the immunoreactivity of two important superoxide radical scavenging intracellular antioxidant enzymes, manganese superoxide dismutase (MnSOD) and copperzinc superoxide dismutase (CuZnSOD), in pulmonary sarcoidosis and extrinsic allergic alveolitis. Superoxides 68-86 superoxide dismutase 2 Homo sapiens 133-163 9741582-10 1998 Increased steady state [O2.-] in the presence of .NO yields ONOO , and ONOO has direct, stimulatory effects on MnSOD transcript expression. Superoxides 24-26 superoxide dismutase 2 Homo sapiens 111-116 9886257-2 1999 MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen. Superoxides 21-37 superoxide dismutase 2 Homo sapiens 0-5 9853553-7 1998 Upregulation of MnSOD in cancer tissue most likely serves as a protective mechanism against anti-cancer therapies known to produce superoxide radicals as a key component of their tumor-killing activity. Superoxides 131-150 superoxide dismutase 2 Homo sapiens 16-21 9700139-2 1998 In this study we investigated the immunoreactivity of two important superoxide radical scavenging intracellular antioxidant enzymes, manganese superoxide dismutase (MnSOD) and copperzinc superoxide dismutase (CuZnSOD), in pulmonary sarcoidosis and extrinsic allergic alveolitis. Superoxides 68-86 superoxide dismutase 2 Homo sapiens 165-170 9537988-10 1998 Also, unlike the wild-type Mn(III)SOD, which is electron paramagnetic resonance (EPR) silent, Q143N MnSOD has a complex EPR spectrum with many resonances in the region below 2250 G. We conclude that the Gln 143 --> Asn mutation has increased the reduction potential of manganese to stabilize Mn(II), indicating that Gln 143 has a substantial role in maintaining a reduction potential favorable for the oxidation and reduction cycles in the catalytic disproportionation of superoxide. Superoxides 475-485 superoxide dismutase 2 Homo sapiens 100-105 9773743-11 1998 The apparently paradoxical increase in MnSOD expression may be an adaptive response to increased superoxide generation. Superoxides 97-107 superoxide dismutase 2 Homo sapiens 39-44 9728339-1 1998 Manganese superoxide dismutase (MnSOD) is the mitochondrial enzyme that disposes of superoxide generated by respiratory chain activity. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 9728339-2 1998 Of all electrons passing down the mitochondrial respiratory chain, 1-2% are diverted to form superoxide; thus production of hydrogen peroxide occurs at a constant rate due to MnSOD activity. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 175-180 9519816-3 1998 However, the sensitivity of HeLa cells against methylmercury was decreased by overexpression of Mn-SOD, an enzyme localized in matrix of mitochondria and which decomposes superoxide anions. Superoxides 171-188 superoxide dismutase 2 Homo sapiens 96-102 9371723-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that scavenges superoxide (O2-) ions. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 12174293-3 1998 Manganese superoxide dismutase (MnSOD) is a mitochondrial antioxidant enzyme involved in scavenging O(2)(-). Superoxides 100-104 superoxide dismutase 2 Homo sapiens 32-37 9409558-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen. Superoxides 99-117 superoxide dismutase 2 Homo sapiens 0-30 9409558-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen. Superoxides 99-117 superoxide dismutase 2 Homo sapiens 32-37 9371723-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that scavenges superoxide (O2-) ions. Superoxides 92-94 superoxide dismutase 2 Homo sapiens 0-30 9371723-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that scavenges superoxide (O2-) ions. Superoxides 92-94 superoxide dismutase 2 Homo sapiens 32-37 8663465-1 1996 The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and by stopped-flow spectrophotometry. Superoxides 17-27 superoxide dismutase 2 Homo sapiens 47-77 9067545-6 1997 Overexpression of MnSOD led to a significant decrease in c-jun and c-fos expression in response to treatment with TPA or the oxidant promoter superoxide. Superoxides 142-152 superoxide dismutase 2 Homo sapiens 18-23 8702551-3 1996 Mn-SOD is a nuclear-encoded mitochondrial matrix protein and serves a protective function by detoxifying superoxide. Superoxides 105-115 superoxide dismutase 2 Homo sapiens 0-6 8702551-10 1996 These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF-induced IL-1alpha expression, presumably superoxide. Superoxides 166-176 superoxide dismutase 2 Homo sapiens 34-40 9223372-4 1997 This expression system was used to study the effects of paraquat and menadione, two intracellular superoxide generators, on processing of precursor hMn-SOD by insect mitochondria. Superoxides 98-108 superoxide dismutase 2 Homo sapiens 148-155 8663465-1 1996 The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and by stopped-flow spectrophotometry. Superoxides 17-27 superoxide dismutase 2 Homo sapiens 79-84 8663465-1 1996 The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and by stopped-flow spectrophotometry. Superoxides 57-67 superoxide dismutase 2 Homo sapiens 79-84 8764104-1 1996 Manganese superoxide dismutase (MnSOD) is a superoxide anion scavenger located in mitochondria. Superoxides 44-60 superoxide dismutase 2 Homo sapiens 0-30 8764104-1 1996 Manganese superoxide dismutase (MnSOD) is a superoxide anion scavenger located in mitochondria. Superoxides 44-60 superoxide dismutase 2 Homo sapiens 32-37 8661822-7 1996 Up-regulation of Mn-SOD mRNA in gastric carcinoma tissue most likely serves as a protective mechanism against superoxide radicals and TNF cytotoxicity. Superoxides 110-120 superoxide dismutase 2 Homo sapiens 17-23 8755643-8 1996 However, the observed superoxide production rates are modulated by the variant induction of MnSOD which decreases the rates, sometimes below those seen in control fibroblast mitochondria. Superoxides 22-32 superoxide dismutase 2 Homo sapiens 92-97 8665512-1 1996 Manganese superoxide dismutase (Mn-SOD) inactivates the radiation effect by removal of radiation-induced toxic superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-38 21594386-2 1996 The known function of MnSOD is to remove superoxide radicals generated in the mitochondria. Superoxides 41-51 superoxide dismutase 2 Homo sapiens 22-27 8605177-9 1996 Rapid inactivation of Ile58Thr MnSOD at the elevated temperatures associated with fever and inflammation could provide an early advantage by killing infected cells, but also would increase superoxide-mediated oxidative damage and perhaps contribute to late-onset diseases. Superoxides 189-199 superoxide dismutase 2 Homo sapiens 31-36 8602839-1 1996 Human manganese-containing superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial protein that scavenges potentially toxic superoxide radicals by dismuting O2- to O2 plus H2O2. Superoxides 27-37 superoxide dismutase 2 Homo sapiens 49-54 8602839-1 1996 Human manganese-containing superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial protein that scavenges potentially toxic superoxide radicals by dismuting O2- to O2 plus H2O2. Superoxides 165-167 superoxide dismutase 2 Homo sapiens 6-47 8602839-1 1996 Human manganese-containing superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial protein that scavenges potentially toxic superoxide radicals by dismuting O2- to O2 plus H2O2. Superoxides 165-167 superoxide dismutase 2 Homo sapiens 49-54 8602839-1 1996 Human manganese-containing superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial protein that scavenges potentially toxic superoxide radicals by dismuting O2- to O2 plus H2O2. Superoxides 172-174 superoxide dismutase 2 Homo sapiens 6-47 8602839-1 1996 Human manganese-containing superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial protein that scavenges potentially toxic superoxide radicals by dismuting O2- to O2 plus H2O2. Superoxides 172-174 superoxide dismutase 2 Homo sapiens 49-54 8580367-8 1995 MnSOD acts as a scaveneger of toxic superoxide radicals and its induction by TNF paralleled arachidonic acid release. Superoxides 36-46 superoxide dismutase 2 Homo sapiens 0-5 8886804-2 1996 Manganese superoxide dismutase (MnSOD), a mitochondrial superoxide radical scavenging enzyme, is low in most tumors but is known to be induced by asbestos fibers and certain cytokines. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 8886804-8 1996 Cytotoxicity experiments, which were conducted in four cell lines, indicated that cells containing high MnSOD mRNA level and activity were resistant to the mitochondrial superoxide-producing agent menadione. Superoxides 170-180 superoxide dismutase 2 Homo sapiens 104-109 8602757-1 1996 Superoxide dismutases (SODs) are metalloenzymes that detoxify superoxide radicals, and occur in cytosolic (Cu,Zn-SOD) and mitochondrial (Mn-SOD) forms in multiple tissues, including brain. Superoxides 62-72 superoxide dismutase 2 Homo sapiens 137-143 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 100-118 superoxide dismutase 2 Homo sapiens 0-30 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 100-118 superoxide dismutase 2 Homo sapiens 32-38 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 120-122 superoxide dismutase 2 Homo sapiens 0-30 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 120-122 superoxide dismutase 2 Homo sapiens 32-38 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 184-186 superoxide dismutase 2 Homo sapiens 0-30 7622845-1 1995 Manganese superoxide dismutase (Mn SOD), mitochondrial enzyme, defends against the toxic effects of superoxide radical (O2.-) in pathological processes by catalyzing the conversion of O2.- to hydrogen peroxide (H2O2). Superoxides 184-186 superoxide dismutase 2 Homo sapiens 32-38 8775911-8 1995 The superoxide radical-SOD system might play an important role in ovulation and in the luteal function of the human ovary. Superoxides 4-14 superoxide dismutase 2 Homo sapiens 23-26 7702755-1 1994 Human manganese superoxide dismutase (MnSOD) is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Superoxides 16-26 superoxide dismutase 2 Homo sapiens 38-43 7797591-3 1995 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2..-. Superoxides 88-90 superoxide dismutase 2 Homo sapiens 0-30 7797591-3 1995 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2..-. Superoxides 88-90 superoxide dismutase 2 Homo sapiens 32-37 7599209-5 1995 MnSOD, identified as one of the protective proteins, is a mitochondrial enzyme that scavenges superoxide radicals (O2-). Superoxides 94-104 superoxide dismutase 2 Homo sapiens 0-5 7599209-5 1995 MnSOD, identified as one of the protective proteins, is a mitochondrial enzyme that scavenges superoxide radicals (O2-). Superoxides 115-117 superoxide dismutase 2 Homo sapiens 0-5 8077189-10 1994 Manganese superoxide dismutase (MnSOD) is thought to be the sole enzymic scavenger of superoxide in mammalian mitochondria. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 7964476-5 1994 In vitro, the autoantibodies were shown to inhibit the dismutation of superoxide radicals by blocking MnSOD. Superoxides 70-80 superoxide dismutase 2 Homo sapiens 102-107 1988135-1 1991 Manganese superoxide dismutase (MnSOD) is a member of a family of metalloenzymes that catalyze the dismutation of the superoxide anion to H2O2. Superoxides 118-134 superoxide dismutase 2 Homo sapiens 0-30 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 131-133 superoxide dismutase 2 Homo sapiens 45-68 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 131-133 superoxide dismutase 2 Homo sapiens 70-73 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 139-141 superoxide dismutase 2 Homo sapiens 45-68 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 139-141 superoxide dismutase 2 Homo sapiens 70-73 7915978-3 1993 Since beta cells contain low amounts of the superoxide radical scavenger enzyme manganese superoxide dismutase (MnSOD), this may leave beta cells more susceptible to IL-1 than other cell types. Superoxides 44-54 superoxide dismutase 2 Homo sapiens 112-117 8260539-3 1993 On the other hand, TNF or radiation treatment can stimulate the expression of a mitochondrial superoxide scavenging enzyme, manganese superoxide dismutase (MnSOD), which can lower the cytotoxic effects of both agents. Superoxides 94-104 superoxide dismutase 2 Homo sapiens 124-154 8260539-3 1993 On the other hand, TNF or radiation treatment can stimulate the expression of a mitochondrial superoxide scavenging enzyme, manganese superoxide dismutase (MnSOD), which can lower the cytotoxic effects of both agents. Superoxides 94-104 superoxide dismutase 2 Homo sapiens 156-161 8232185-1 1993 The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies. Superoxides 33-43 superoxide dismutase 2 Homo sapiens 296-302 8232185-1 1993 The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies. Superoxides 117-119 superoxide dismutase 2 Homo sapiens 30-53 8232185-1 1993 The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies. Superoxides 125-127 superoxide dismutase 2 Homo sapiens 30-53 8394950-8 1993 Besides reducing the excessive O2- formation, methylprednisolone induced an increase in polymorph expression of the gene encoding for manganese superoxide dismutase (Mn-SOD) enzyme. Superoxides 31-33 superoxide dismutase 2 Homo sapiens 134-164 8394950-8 1993 Besides reducing the excessive O2- formation, methylprednisolone induced an increase in polymorph expression of the gene encoding for manganese superoxide dismutase (Mn-SOD) enzyme. Superoxides 31-33 superoxide dismutase 2 Homo sapiens 166-172 8394950-10 1993 Methylprednisolone normalizes the abnormal generation of O2-, likely through its ability to up-regulate the gene for Mn-SOD, a potent antioxidant enzyme. Superoxides 57-59 superoxide dismutase 2 Homo sapiens 117-123 8392494-9 1993 Inhibition of MnSOD activity in PMN secondary to cytokine exposure in the asthmatic lung could explain, at least in part, the increased generation of superoxide from PMN obtained from asthmatics. Superoxides 150-160 superoxide dismutase 2 Homo sapiens 14-19 1582797-1 1992 Human retinal pigment epithelium (RPE) contains two genetically distinct forms of superoxide dismutase (SOD) enzymes that scavenge harmful superoxide anions. Superoxides 139-156 superoxide dismutase 2 Homo sapiens 104-107 1654848-1 1991 Stable nitroxide radicals have been previously shown to function as superoxide dismutase (SOD)2 mimics and to protect mammalian cells against superoxide and hydrogen peroxide-mediated oxidative stress. Superoxides 68-78 superoxide dismutase 2 Homo sapiens 90-95 1668725-9 1991 TNF-alpha induces manganese-containing superoxide dismutase (MnSOD) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide. Superoxides 84-86 superoxide dismutase 2 Homo sapiens 18-59 1668725-9 1991 TNF-alpha induces manganese-containing superoxide dismutase (MnSOD) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide. Superoxides 84-86 superoxide dismutase 2 Homo sapiens 61-66 7484097-4 1995 These results suggest that the increased Mn SOD immunoreactivity in MKHD reflects enzyme induction as a protective mechanism against the highly toxic superoxide anion generated under the disease conditions. Superoxides 150-166 superoxide dismutase 2 Homo sapiens 41-47 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 110-129 superoxide dismutase 2 Homo sapiens 45-68 7509102-1 1993 The intracellular localization of Cu/Zn- and Mn-superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O2-) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. Superoxides 110-129 superoxide dismutase 2 Homo sapiens 70-73 1311175-3 1992 Enzymic reactions were studied in which Cu,Zn-SOD, Mn-SOD and Fe-SOD each competed with the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) for superoxide anion (O2-) at pH 7.8 O2- from dissolved KO2 (potassium superoxide) in dimethyl sulphoxide was added directly to the enzyme solutions containing DMPO. Superoxides 146-162 superoxide dismutase 2 Homo sapiens 51-57 1311175-3 1992 Enzymic reactions were studied in which Cu,Zn-SOD, Mn-SOD and Fe-SOD each competed with the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) for superoxide anion (O2-) at pH 7.8 O2- from dissolved KO2 (potassium superoxide) in dimethyl sulphoxide was added directly to the enzyme solutions containing DMPO. Superoxides 164-166 superoxide dismutase 2 Homo sapiens 51-57 1311175-3 1992 Enzymic reactions were studied in which Cu,Zn-SOD, Mn-SOD and Fe-SOD each competed with the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) for superoxide anion (O2-) at pH 7.8 O2- from dissolved KO2 (potassium superoxide) in dimethyl sulphoxide was added directly to the enzyme solutions containing DMPO. Superoxides 179-181 superoxide dismutase 2 Homo sapiens 51-57 1311175-4 1992 The results show that, in this competition reaction system, the kinetics of the reactions between the enzymes and O2- follow a function y = f[( SOD]0.5). Superoxides 114-116 superoxide dismutase 2 Homo sapiens 144-147 1959661-1 1991 Manganese superoxide dismutase (MnSOD) is a nuclear encoded mitochondrial matrix enzyme that functions to scavenge superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 1682406-12 1991 These data suggested that free radicals including superoxide anion are possibly involved in the pathogenesis of the disease and Mn-SOD may play some role in a protection against the superoxide anion. Superoxides 182-198 superoxide dismutase 2 Homo sapiens 128-134 1850207-2 1991 Manganese superoxide dismutase (Mn-SOD) is a superoxide anion (O2-.) Superoxides 45-61 superoxide dismutase 2 Homo sapiens 0-30 1850207-2 1991 Manganese superoxide dismutase (Mn-SOD) is a superoxide anion (O2-.) Superoxides 45-61 superoxide dismutase 2 Homo sapiens 32-38 1850207-2 1991 Manganese superoxide dismutase (Mn-SOD) is a superoxide anion (O2-.) Superoxides 63-65 superoxide dismutase 2 Homo sapiens 0-30 1850207-2 1991 Manganese superoxide dismutase (Mn-SOD) is a superoxide anion (O2-.) Superoxides 63-65 superoxide dismutase 2 Homo sapiens 32-38 1850207-15 1991 Our results suggest that the induction of Mn-SOD by TNF-alpha in pulmonary adenocarcinoma cells is pretranslationally mediated and that increasing Mn-SOD activity with TNF-alpha confers protection against O2 radicals. Superoxides 205-207 superoxide dismutase 2 Homo sapiens 147-153 1988135-1 1991 Manganese superoxide dismutase (MnSOD) is a member of a family of metalloenzymes that catalyze the dismutation of the superoxide anion to H2O2. Superoxides 118-134 superoxide dismutase 2 Homo sapiens 32-37 22723845-4 2012 Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS. Superoxides 70-80 superoxide dismutase 2 Homo sapiens 0-22 33761612-4 2021 Previously, we have observed that the plasma concentration/activity of superoxide dismutase isozymes differs in the context of obesity and/or rs2234694 (SOD1) and rs4880 (SOD2) and that the concentrations of SOD1, SOD2, SOD3 are correlated with each other. Superoxides 71-81 superoxide dismutase 2 Homo sapiens 171-175 33761612-4 2021 Previously, we have observed that the plasma concentration/activity of superoxide dismutase isozymes differs in the context of obesity and/or rs2234694 (SOD1) and rs4880 (SOD2) and that the concentrations of SOD1, SOD2, SOD3 are correlated with each other. Superoxides 71-81 superoxide dismutase 2 Homo sapiens 214-218 33761612-6 2021 In this study, the variability of concentration/activity of superoxide dismutase isozymes in plasma is considered in the context of type 2 diabetes and/or SNPs: rs2234694 (SOD1), rs5746105 (SOD2), rs4880 (SOD2), rs927450 (SOD2), rs8192287 (SOD3). Superoxides 60-70 superoxide dismutase 2 Homo sapiens 190-194 33761612-6 2021 In this study, the variability of concentration/activity of superoxide dismutase isozymes in plasma is considered in the context of type 2 diabetes and/or SNPs: rs2234694 (SOD1), rs5746105 (SOD2), rs4880 (SOD2), rs927450 (SOD2), rs8192287 (SOD3). Superoxides 60-70 superoxide dismutase 2 Homo sapiens 205-209 33761612-6 2021 In this study, the variability of concentration/activity of superoxide dismutase isozymes in plasma is considered in the context of type 2 diabetes and/or SNPs: rs2234694 (SOD1), rs5746105 (SOD2), rs4880 (SOD2), rs927450 (SOD2), rs8192287 (SOD3). Superoxides 60-70 superoxide dismutase 2 Homo sapiens 205-209 22723845-4 2012 Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS. Superoxides 70-80 superoxide dismutase 2 Homo sapiens 24-28 35624792-1 2022 The superoxide dismutase (SOD) family functions as a reactive oxygen species (ROS)-scavenging system by converting superoxide anions into hydrogen peroxide in the cytosol (SOD1), mitochondria (SOD2), and extracellular matrix (SOD3). Superoxides 115-132 superoxide dismutase 2 Homo sapiens 193-197 34958669-1 2022 Superoxide dismutase 2 (SOD2) catalyzes the dismutation of superoxide to hydrogen peroxide in mitochondria limiting mitochondrial damage. Superoxides 59-69 superoxide dismutase 2 Homo sapiens 0-22 34958669-1 2022 Superoxide dismutase 2 (SOD2) catalyzes the dismutation of superoxide to hydrogen peroxide in mitochondria limiting mitochondrial damage. Superoxides 59-69 superoxide dismutase 2 Homo sapiens 24-28 34667598-2 2021 Recently, a single nucleotide polymorphism of the gene coding for mitochondrial superoxide dismutase (SOD2), namely the missense substitution A16V (C47>T) resulting in alteration of SOD2 enzyme activity, has been reported to be associated with MCS. Superoxides 80-90 superoxide dismutase 2 Homo sapiens 102-106 34667598-2 2021 Recently, a single nucleotide polymorphism of the gene coding for mitochondrial superoxide dismutase (SOD2), namely the missense substitution A16V (C47>T) resulting in alteration of SOD2 enzyme activity, has been reported to be associated with MCS. Superoxides 80-90 superoxide dismutase 2 Homo sapiens 182-186 34968705-2 2022 By regulating superoxide levels, manganese superoxide dismutase plays important roles in numerous biochemical and molecular events essential for the survival of aerobic life. Superoxides 14-24 superoxide dismutase 2 Homo sapiens 33-63 35594792-4 2022 Using ovarian cancer cells as a model, we demonstrate that an increase in mitochondrial superoxide dismutase SOD2 protein expression is a very early event initiated in response to detachment, an important step during metastasis that has been associated with increased oxidative stress. Superoxides 88-98 superoxide dismutase 2 Homo sapiens 109-113 35274104-2 2022 Superoxide dismutase 2 (SOD2) is a mitochondrial-localized enzyme that catalyzes the dismutation of superoxide to hydrogen peroxide. Superoxides 100-110 superoxide dismutase 2 Homo sapiens 0-22 35453320-5 2022 One example of such an antioxidant enzyme is manganese superoxide dismutase (MnSOD, also referred to as SOD2), which detoxifies superoxide, a ROS that has been shown, when its normal physiological levels are disrupted, to lead to oncogenicity and therapy resistance. Superoxides 128-138 superoxide dismutase 2 Homo sapiens 45-75 35453320-5 2022 One example of such an antioxidant enzyme is manganese superoxide dismutase (MnSOD, also referred to as SOD2), which detoxifies superoxide, a ROS that has been shown, when its normal physiological levels are disrupted, to lead to oncogenicity and therapy resistance. Superoxides 128-138 superoxide dismutase 2 Homo sapiens 77-82 35453320-5 2022 One example of such an antioxidant enzyme is manganese superoxide dismutase (MnSOD, also referred to as SOD2), which detoxifies superoxide, a ROS that has been shown, when its normal physiological levels are disrupted, to lead to oncogenicity and therapy resistance. Superoxides 128-138 superoxide dismutase 2 Homo sapiens 104-108 35447940-8 2022 Moreover, the expression of the antioxidant enzymes superoxide dismutase (SOD1 and SOD2) in CA1-3 pyramidal cells were gradually and significantly reduced after ischemia. Superoxides 52-62 superoxide dismutase 2 Homo sapiens 83-87 35274104-2 2022 Superoxide dismutase 2 (SOD2) is a mitochondrial-localized enzyme that catalyzes the dismutation of superoxide to hydrogen peroxide. Superoxides 100-110 superoxide dismutase 2 Homo sapiens 24-28 33079465-4 2021 The nanozyme prevents the mitochondrial damage in SOD1 and SOD2-depleted cells by regulating the superoxide levels and restores the physiological levels of the anti-apoptotic Bcl-2 family proteins. Superoxides 97-107 superoxide dismutase 2 Homo sapiens 59-63 35205334-4 2022 This study aimed to evaluate changes in IL-6 concentration and the concentration/activity of superoxide dismutase isoenzymes (SOD1, SOD2, and SOD3) in the blood of patients with acute pancreatitis (AP) in terms of rs1800795 polymorphism in the IL6 gene. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 132-136 3838941-6 1985 Human manganese superoxide dismutase was also found to dismute the superoxide radical to hydrogen peroxide and water. Superoxides 67-85 superoxide dismutase 2 Homo sapiens 6-36 35110539-9 2022 Moreover, baicalein treatment inhibited ferroptosis in adenine-stimulated PTEC by selectively modulating the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) and thus, suppressing mitochondrial superoxide production and DNA damage. Superoxides 208-218 superoxide dismutase 2 Homo sapiens 142-164 35110539-9 2022 Moreover, baicalein treatment inhibited ferroptosis in adenine-stimulated PTEC by selectively modulating the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) and thus, suppressing mitochondrial superoxide production and DNA damage. Superoxides 208-218 superoxide dismutase 2 Homo sapiens 166-170 2476237-2 1989 Here we demonstrate that manganous superoxide dismutase (MnSOD), a mitochondrial enzyme involved in the scavenging of superoxide radicals (O2-), is such a protein. Superoxides 35-45 superoxide dismutase 2 Homo sapiens 57-62 2476237-2 1989 Here we demonstrate that manganous superoxide dismutase (MnSOD), a mitochondrial enzyme involved in the scavenging of superoxide radicals (O2-), is such a protein. Superoxides 139-141 superoxide dismutase 2 Homo sapiens 25-55 2476237-2 1989 Here we demonstrate that manganous superoxide dismutase (MnSOD), a mitochondrial enzyme involved in the scavenging of superoxide radicals (O2-), is such a protein. Superoxides 139-141 superoxide dismutase 2 Homo sapiens 57-62 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 78-94 superoxide dismutase 2 Homo sapiens 12-18 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 78-94 superoxide dismutase 2 Homo sapiens 206-212 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 137-153 superoxide dismutase 2 Homo sapiens 12-18 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 137-153 superoxide dismutase 2 Homo sapiens 206-212 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 137-153 superoxide dismutase 2 Homo sapiens 12-18 3495372-6 1987 The loss of Mn SOD activity could be mediated by a low intracellular level of superoxide anion due to the scavenger effect of melanin on superoxide anion; in fact, it is well known that the biosynthesis of Mn SOD is induced by intracellular levels of superoxide anion. Superoxides 137-153 superoxide dismutase 2 Homo sapiens 206-212 4039529-5 1985 Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. Superoxides 55-72 superoxide dismutase 2 Homo sapiens 10-15 6316150-1 1983 Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper. Superoxides 99-117 superoxide dismutase 2 Homo sapiens 35-38 33189402-1 2021 Superoxide-hydrogen peroxide (S-HP), triggered by Val16Ala-SOD2 human polymorphism, may influence the risk of depression. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 59-63 33867840-2 2021 We have previously demonstrated that MnSOD lysine-68 (K68) acetylation (K68-Ac) leads to a change in function from a superoxide-scavenging homotetramer to a peroxidase-directed monomer. Superoxides 117-127 superoxide dismutase 2 Homo sapiens 37-42 33535682-10 2021 Ala-SOD2 SNP cells exhibited increased levels of total ROS and superoxide and were more sensitive to co-treatment with H2O2 and MSKE, which led to reduced cell growth and increased apoptosis. Superoxides 63-73 superoxide dismutase 2 Homo sapiens 4-8 33009206-2 2021 Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. Superoxides 0-16 superoxide dismutase 2 Homo sapiens 70-100 33009206-2 2021 Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. Superoxides 0-16 superoxide dismutase 2 Homo sapiens 102-106 32527005-5 2020 Antioxidant Mn-activated superoxide dismutase (SOD2) and (m)-aconitase activities were increased in HCM vs. CTRL. Superoxides 25-35 superoxide dismutase 2 Homo sapiens 47-51 32222623-7 2020 Mechanistically, we provide compelling evidence that PM2.5 reduces SOD2 expression through activation of Akt pathway, which leads to a disruption of mitochondrial redox homeostasis characterized by increased accumulation of mitochondrial superoxide. Superoxides 238-248 superoxide dismutase 2 Homo sapiens 67-71 31591207-1 2019 Mitochondrial superoxide dismutase (SOD2) suppresses tumor initiation but promotes invasion and dissemination of tumor cells at later stages of the disease. Superoxides 14-24 superoxide dismutase 2 Homo sapiens 36-40 32466166-9 2020 SOD2 expression was reduced upon exposure to B. burgdorferi, suggesting that B. burgdorferi might be responsible for superoxide reduction. Superoxides 117-127 superoxide dismutase 2 Homo sapiens 0-4 31968997-4 2020 This review discusses how mitochondrial superoxide dismutase (SOD2) plays two critical roles in facilitating redox signaling. Superoxides 40-50 superoxide dismutase 2 Homo sapiens 62-66 31891227-0 2020 Superoxide imbalance triggered by Val16Ala-SOD2 polymorphism increases the risk of depression and self-reported psychological stress in free-living elderly people. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 43-47 31891227-2 2020 However, it is still not clear whether the VV-SOD2 genotype that causes higher basal superoxide anion levels has any impact on the risk for depression and self-reported psychological stress in elderly people. Superoxides 85-101 superoxide dismutase 2 Homo sapiens 46-50 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Superoxides 254-270 superoxide dismutase 2 Homo sapiens 18-40 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Superoxides 254-270 superoxide dismutase 2 Homo sapiens 42-46 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Superoxides 254-270 superoxide dismutase 2 Homo sapiens 51-81 32222469-10 2020 This decrease in SOD2 K122 acetylation correlates with an increase in SOD2 activity and mitochondrial superoxide scavenging capacity. Superoxides 102-112 superoxide dismutase 2 Homo sapiens 17-21 32149414-10 2020 First, proper level of SOD2 helped CRC cells maintain mitochondrial function by disposal of superoxide (O2 .- ). Superoxides 92-102 superoxide dismutase 2 Homo sapiens 23-27 31904901-4 2020 Superoxide anions are metabolized by manganese-dependent superoxide dismutase (SOD2) in the mitochondria. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 79-83 31904901-4 2020 Superoxide anions are metabolized by manganese-dependent superoxide dismutase (SOD2) in the mitochondria. Superoxides 57-67 superoxide dismutase 2 Homo sapiens 79-83 31919630-6 2020 The high SOD2 levels in UFM and PM cells correlated with lower levels of superoxide and reactive oxygen species (ROS), and with morphological anomalies and depolarization of the mitochondrial membrane detected through confocal microscopy. Superoxides 73-83 superoxide dismutase 2 Homo sapiens 9-13 31919630-9 2020 Overall, these data suggest that in PM and UFM carriers, which have high levels of FMR1 transcription and may develop FXTAS, SOD2 overexpression helps to maintain low levels of both superoxide and ROS with signs of mitochondrial degradation. Superoxides 182-192 superoxide dismutase 2 Homo sapiens 125-129 31723239-6 2020 Mechanistically, SIRT3 prevents mitochondrial superoxide surges in detached cells by regulating the manganese superoxide dismutase (SOD2). Superoxides 100-120 superoxide dismutase 2 Homo sapiens 132-136 31648572-7 2020 Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential. Superoxides 1386-1396 superoxide dismutase 2 Homo sapiens 1381-1385 30464607-15 2018 Both PRL-3 and RAP1 could regulate the expression of manganese superoxide dismutase 2 (SOD2) and the uncoupling protein 2 (UCP2), which may be related to PRL-3 suppression induced mitochondria superoxide anion. Superoxides 193-209 superoxide dismutase 2 Homo sapiens 87-91 31629402-7 2019 SOD2 in the resistant cells functionally determined the cell fate by limiting TMZ-stimulated superoxide reaction and cleavage of caspase-3. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 0-4 30193891-7 2018 MnSOD then converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion. Superoxides 20-30 superoxide dismutase 2 Homo sapiens 0-5 31506286-5 2019 Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 0-22 31506286-5 2019 Superoxide dismutase 2 (SOD2) is a mitochondrial-specific antioxidant enzyme that dismutates superoxide to hydrogen peroxide, which is then converted to water by catalase and glutathione peroxidase. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 24-28 30486606-4 2018 Low antioxidant MnSOD level in breast cancer cell line MCF-7 leads to low concentration of hydrogenperoxide, because antioxidant MnSOD will convert radical superoxide to hydrogen peroxide. Superoxides 156-166 superoxide dismutase 2 Homo sapiens 16-21 30486606-4 2018 Low antioxidant MnSOD level in breast cancer cell line MCF-7 leads to low concentration of hydrogenperoxide, because antioxidant MnSOD will convert radical superoxide to hydrogen peroxide. Superoxides 156-166 superoxide dismutase 2 Homo sapiens 129-134 30279321-2 2018 Mitochondria are the source of up to 90% of cellular ROS generation, and MnSOD performs its necessary bioprotective role by converting superoxide into oxygen and hydrogen peroxide. Superoxides 135-145 superoxide dismutase 2 Homo sapiens 73-78 29459008-1 2018 BACKGROUND: Superoxide dismutase-2 (SOD2, OMIM: 147460) is involved in the detoxification of superoxide anions. Superoxides 93-110 superoxide dismutase 2 Homo sapiens 12-34 30037352-2 2018 Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still poorly understood. Superoxides 100-117 superoxide dismutase 2 Homo sapiens 45-49 29466765-3 2018 Previous investigations described association between a genetic superoxide-hydrogen (S-HP) imbalance caused by a superoxide dismutase manganese dependent gene polymorphism (Val16Ala-SOD2 SNP, rs4880) and differential anti-inflammatory response of some drugs and bioactive molecules. Superoxides 64-74 superoxide dismutase 2 Homo sapiens 182-186 29737331-1 2018 Human MnSOD is a homotetramer and represents an essential mitochondrial antioxidant enzyme, which catalyzes the dismutation of superoxide radicals (O2 -) at near diffusion-controlled rates. Superoxides 127-137 superoxide dismutase 2 Homo sapiens 6-11 29737331-1 2018 Human MnSOD is a homotetramer and represents an essential mitochondrial antioxidant enzyme, which catalyzes the dismutation of superoxide radicals (O2 -) at near diffusion-controlled rates. Superoxides 148-150 superoxide dismutase 2 Homo sapiens 6-11 29459008-1 2018 BACKGROUND: Superoxide dismutase-2 (SOD2, OMIM: 147460) is involved in the detoxification of superoxide anions. Superoxides 93-110 superoxide dismutase 2 Homo sapiens 36-40 29282552-1 2018 Superoxide dismutases (SOD) are vital enzymes for disproportionation of superoxide molecules in mammals. Superoxides 72-82 superoxide dismutase 2 Homo sapiens 23-26 29099803-4 2017 SOD2 has both tumor suppressive and promoting functions, which are primarily related to its role as a mitochondrial superoxide scavenger and H2O2 regulator. Superoxides 116-126 superoxide dismutase 2 Homo sapiens 0-4 29851012-6 2018 Superoxide dismutase (MnSOD, SOD2) from the mitochondrial matrix, as well as superoxide dismutase (Cu/ZnSOD, SOD1) present in small amounts in the mitochondrial intramembrane space, converts superoxide anion to hydrogen peroxide, which can be then converted by catalase to harmless H2O.In the chapter we describe a relation between mitochondrial membrane potential and the rate of ROS formation. Superoxides 191-207 superoxide dismutase 2 Homo sapiens 22-27 29851012-6 2018 Superoxide dismutase (MnSOD, SOD2) from the mitochondrial matrix, as well as superoxide dismutase (Cu/ZnSOD, SOD1) present in small amounts in the mitochondrial intramembrane space, converts superoxide anion to hydrogen peroxide, which can be then converted by catalase to harmless H2O.In the chapter we describe a relation between mitochondrial membrane potential and the rate of ROS formation. Superoxides 191-207 superoxide dismutase 2 Homo sapiens 29-33 28038454-4 2017 Furthermore, by over-expression of MnSOD and GPx in cells, we show that ROS, and especially superoxide, is the primary oxidative species induced by intense heat stress and responsible for cell death. Superoxides 92-102 superoxide dismutase 2 Homo sapiens 35-40 28461152-2 2017 The azide anion is a potent competitive inhibitor that binds directly to the metal and is used as a substrate analog to superoxide in studies of SOD. Superoxides 120-130 superoxide dismutase 2 Homo sapiens 145-148 28461152-3 2017 The crystal structure of human MnSOD-azide complex was solved and shows the putative binding position of superoxide, providing a model for binding to the active site. Superoxides 105-115 superoxide dismutase 2 Homo sapiens 31-36 28495429-2 2017 Into mitochondria, MnSOD catalyses superoxide radical producing HP and oxygen. Superoxides 35-53 superoxide dismutase 2 Homo sapiens 19-24 28398002-3 2017 Here, we demonstrate that an increase in superoxide anion radicals due to superoxide dismutase 2 (Sod2) deficiency in stromal precursor cells suppress osteogenic and adipogenic differentiation through fundamental changes in the global metabolite landscape. Superoxides 41-66 superoxide dismutase 2 Homo sapiens 74-96 28398002-3 2017 Here, we demonstrate that an increase in superoxide anion radicals due to superoxide dismutase 2 (Sod2) deficiency in stromal precursor cells suppress osteogenic and adipogenic differentiation through fundamental changes in the global metabolite landscape. Superoxides 41-66 superoxide dismutase 2 Homo sapiens 98-102 28587495-1 2017 Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1). Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 26882122-2 2016 Superoxide anions are metabolized by manganese-dependent superoxide dismutase (MnSOD or SOD2) in the mitochondria. Superoxides 0-17 superoxide dismutase 2 Homo sapiens 79-84 28165386-8 2017 Thus, LC-MS/MS analysis revealed multiple oxidative modifications of MNSOD at different amino acid residues that might mediate the regulation of the superoxide radicals, mitochondrial ROS scavenging and MNSOD activity in kidney cancer. Superoxides 149-159 superoxide dismutase 2 Homo sapiens 69-74 29047081-6 2017 In parallel with these different cellular sites of superoxide production, the three SOD isoforms are also specifically localized to the cytosol (SOD1), mitochondria (SOD2) or extracellular compartment (SOD3). Superoxides 51-61 superoxide dismutase 2 Homo sapiens 166-170 28100855-9 2016 Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Superoxides 121-137 superoxide dismutase 2 Homo sapiens 84-89 27435539-1 2016 Manganese superoxide dismutase (MnSOD) is a vital enzyme that protects cells from free radicals through eliminating superoxide radicals (O2-). Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 27435539-1 2016 Manganese superoxide dismutase (MnSOD) is a vital enzyme that protects cells from free radicals through eliminating superoxide radicals (O2-). Superoxides 137-139 superoxide dismutase 2 Homo sapiens 0-30 27435539-1 2016 Manganese superoxide dismutase (MnSOD) is a vital enzyme that protects cells from free radicals through eliminating superoxide radicals (O2-). Superoxides 137-139 superoxide dismutase 2 Homo sapiens 32-37 27847869-8 2016 Moreover, because of impaired MnSOD activity, ULM cells are sensitive to high levels of reactive oxygen species (ROS) and superoxide-generating compounds, resulting in decreased ULM cell viability. Superoxides 122-132 superoxide dismutase 2 Homo sapiens 30-35 26882122-2 2016 Superoxide anions are metabolized by manganese-dependent superoxide dismutase (MnSOD or SOD2) in the mitochondria. Superoxides 0-17 superoxide dismutase 2 Homo sapiens 88-92 27400860-8 2016 Conversely, gene knockdown of MnSOD results in the reversal of EMT to a mesenchymal-epithelial transition (MET)-like program, which appears to be a function of superoxide (O2(- ))-directed signaling. Superoxides 160-170 superoxide dismutase 2 Homo sapiens 30-35 27400860-8 2016 Conversely, gene knockdown of MnSOD results in the reversal of EMT to a mesenchymal-epithelial transition (MET)-like program, which appears to be a function of superoxide (O2(- ))-directed signaling. Superoxides 172-174 superoxide dismutase 2 Homo sapiens 30-35 27400860-9 2016 INNOVATION AND CONCLUSION: These data underscore the involvement of MnSOD in regulating the switch between the EMT and MET-associated phenotype by influencing cellular redox environment via its effect on the intracellular ratio between O2(- ) and H2O2. Superoxides 236-238 superoxide dismutase 2 Homo sapiens 68-73 26898144-8 2016 Interestingly, treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD expression, eNOS phosphorylation and NO production in endothelial cells. Superoxides 67-77 superoxide dismutase 2 Homo sapiens 238-243 27227512-1 2016 Human Mn-containing superoxide dismutase (hMnSOD) is a mitochondrial enzyme that metabolizes superoxide radical (O2( -)). Superoxides 93-111 superoxide dismutase 2 Homo sapiens 42-48 27227512-1 2016 Human Mn-containing superoxide dismutase (hMnSOD) is a mitochondrial enzyme that metabolizes superoxide radical (O2( -)). Superoxides 113-116 superoxide dismutase 2 Homo sapiens 42-48 26678800-4 2016 This was accompanied by an increase in MitoSOX and DCFH2 oxidation that could be indicative of increased steady-state levels of reactive oxygen species (ROS) such as O2( -) and H2O2, which correlated with increased levels of MnSOD activity and immuno-reactive protein. Superoxides 166-168 superoxide dismutase 2 Homo sapiens 225-230 25908444-2 2015 Manganese superoxide dismutase (SOD2) is the major enzymatic superoxide scavenger present in the mitochondrial matrix and one of the most crucial reactive oxygen species-scavenging enzymes in the cell. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-36 26544677-3 2016 Manganese superoxide dismutase (MnSOD) is the major antioxidant in the mitochondria, catalyzing the metabolism of superoxide radicals to form hydrogen peroxide. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 27630759-1 2016 Mitochondrial superoxide dismutase 2 (SOD2) converts superoxide anions to hydrogen peroxide and oxygen. Superoxides 53-70 superoxide dismutase 2 Homo sapiens 38-42 27630759-6 2016 Elevating cellular superoxide production reduced SOD2 protein content. Superoxides 19-29 superoxide dismutase 2 Homo sapiens 49-53 27630759-11 2016 Increased cellular superoxide anion production might affect SOD2 protein content. Superoxides 19-35 superoxide dismutase 2 Homo sapiens 60-64 26652025-9 2015 Next, we used AdSOD2 to upregulate SOD2 prior to HG exposure and thereby noted reduction in superoxide generation. Superoxides 92-102 superoxide dismutase 2 Homo sapiens 16-20 26400460-1 2015 Manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, is involved in the detoxification of superoxide anion. Superoxides 103-119 superoxide dismutase 2 Homo sapiens 0-30 26400460-1 2015 Manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, is involved in the detoxification of superoxide anion. Superoxides 103-119 superoxide dismutase 2 Homo sapiens 32-37 26400460-1 2015 Manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, is involved in the detoxification of superoxide anion. Superoxides 103-119 superoxide dismutase 2 Homo sapiens 55-59 26899340-4 2016 As mitochondria are the main site of superoxide production, among SODs, mitochondrial manganese SOD (MnSOD) is the primary antioxidant enzyme that protects cells from ROS. Superoxides 37-47 superoxide dismutase 2 Homo sapiens 86-99 26899340-4 2016 As mitochondria are the main site of superoxide production, among SODs, mitochondrial manganese SOD (MnSOD) is the primary antioxidant enzyme that protects cells from ROS. Superoxides 37-47 superoxide dismutase 2 Homo sapiens 101-106 28053678-4 2016 Mitochondria-located manganese superoxide dismutase (MnSOD, SOD2) successfully converts superoxide to the less reactive hydrogen peroxide (H2O2). Superoxides 31-41 superoxide dismutase 2 Homo sapiens 53-58 28053678-4 2016 Mitochondria-located manganese superoxide dismutase (MnSOD, SOD2) successfully converts superoxide to the less reactive hydrogen peroxide (H2O2). Superoxides 31-41 superoxide dismutase 2 Homo sapiens 60-64 26436856-5 2015 Untreated and O2.- treated FeSOD and MnSOD predominantly show 5 d-electron systems, i.e. Fe(3+) and Mn(2+). Superoxides 14-16 superoxide dismutase 2 Homo sapiens 37-42 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Superoxides 60-70 superoxide dismutase 2 Homo sapiens 0-4 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Superoxides 60-70 superoxide dismutase 2 Homo sapiens 156-160 25908444-6 2015 These SOD2 mutations affected the superoxide-scavenging activity in vitro and in HEK293T cells. Superoxides 34-44 superoxide dismutase 2 Homo sapiens 6-10 25908444-10 2015 Thus, the entry of the superoxide anion into the coordinated core of SOD2 was inhibited. Superoxides 23-39 superoxide dismutase 2 Homo sapiens 69-73 25933618-1 2015 AIMS/HYPOTHESIS: Oxidative stress and microvascular damage have been implicated in the pathogenesis of diabetic neuropathy, with manganese superoxide dismutase 2 (SOD2) responsible for superoxide detoxification in mitochondria. Superoxides 139-149 superoxide dismutase 2 Homo sapiens 163-167 26120888-12 2015 These results suggest that melatonin exerts a hepatoprotective effect on mitochondrial-derived O2( -)-stimulated autophagic cell death that is dependent on the SIRT3/SOD2 pathway. Superoxides 95-101 superoxide dismutase 2 Homo sapiens 166-170 26108578-4 2015 We herein demonstrate that mechanical loading promoted mitochondrial superoxide generation and selective Sod2 downregulation in chondrocytes in vivo and that mitochondrial superoxide inducer also downregulated Sod2 expression in chondrocytes in vitro. Superoxides 172-182 superoxide dismutase 2 Homo sapiens 210-214 26108578-5 2015 A genetically manipulated model revealed that Sod2 deficiency in chondrocytes also resulted in mitochondrial superoxide overproduction and dysfunction, thus leading to cartilage degeneration. Superoxides 109-119 superoxide dismutase 2 Homo sapiens 46-50 25561743-6 2015 On the other hand, ectopic expression of Mn-SOD attenuated the arsenite-generated superoxide radical level, abrogated nucleolin-SUMO, and in turn inhibited arsenite-induced apoptosis by reducing GADD45alpha expression. Superoxides 82-100 superoxide dismutase 2 Homo sapiens 41-47 25671321-8 2015 Further, we show that increasing mitochondrial superoxide levels through deletion of sod-2 or treatment with paraquat can still increase lifespan in clk-1;sod-1 double mutants, which live shorter than clk-1 worms. Superoxides 47-57 superoxide dismutase 2 Homo sapiens 85-90 25858870-5 2015 Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O(2)( -)) production. Superoxides 119-129 superoxide dismutase 2 Homo sapiens 10-33 25858870-5 2015 Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O(2)( -)) production. Superoxides 119-129 superoxide dismutase 2 Homo sapiens 35-40 25858870-5 2015 Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O(2)( -)) production. Superoxides 131-135 superoxide dismutase 2 Homo sapiens 10-33 25858870-5 2015 Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O(2)( -)) production. Superoxides 131-135 superoxide dismutase 2 Homo sapiens 35-40 25834301-5 2015 Superoxide is considered to be a major factor in oxidant toxicity, and mitochondrial MnSOD enzymes constitute an essential defense against superoxide. Superoxides 139-149 superoxide dismutase 2 Homo sapiens 85-90 25388628-7 2015 HUVECs overexpressing MnSOD demonstrated an increased activity of endothelial nitric oxide synthase (eNOS), reduced load of superoxide anion (O2 (-) ) and an increased survival under oxidative stress. Superoxides 124-140 superoxide dismutase 2 Homo sapiens 22-27 25388628-7 2015 HUVECs overexpressing MnSOD demonstrated an increased activity of endothelial nitric oxide synthase (eNOS), reduced load of superoxide anion (O2 (-) ) and an increased survival under oxidative stress. Superoxides 142-144 superoxide dismutase 2 Homo sapiens 22-27 25388628-11 2015 In conclusion, 3% w/v beta-d-glucan activates endothelial expression of MnSOD independent of histone acetylation level, thereby leading to adequate removal of O2 (-) , cell survival and angiogenic response to oxidative stress. Superoxides 159-161 superoxide dismutase 2 Homo sapiens 72-77 24055523-3 2013 This study attempted to reverse tamoxifen (TAM)-resistance in breast cancer by silencing a mitochondrial enzyme, manganese superoxide dismutase (MnSOD), which dismutates TAM-induced reactive oxygen species (ROS) (i.e., superoxide) to less harmful hydrogen peroxide and hampers therapeutic effects. Superoxides 123-133 superoxide dismutase 2 Homo sapiens 145-150 25224035-5 2014 Several studies display the biological significance of MnSOD level in proliferation as well as in invasive and angiogenic abilities of breast tumor cells by controlling superoxide anion radical (O2( -)) and hydrogen peroxide (H2O2). Superoxides 169-193 superoxide dismutase 2 Homo sapiens 55-60 25224035-5 2014 Several studies display the biological significance of MnSOD level in proliferation as well as in invasive and angiogenic abilities of breast tumor cells by controlling superoxide anion radical (O2( -)) and hydrogen peroxide (H2O2). Superoxides 195-197 superoxide dismutase 2 Homo sapiens 55-60 24953189-1 2014 Manganese superoxide dismutase (MnSOD), a critical anti-oxidant enzyme, detoxifies the mitochondrial-derived reactive oxygen species, superoxide, elicited through normal respiration or the inflammatory response. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 25109995-3 2014 Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may be critical for tissue homoeostasis. Superoxides 6-16 superoxide dismutase 2 Homo sapiens 165-170 25109995-3 2014 Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may be critical for tissue homoeostasis. Superoxides 6-16 superoxide dismutase 2 Homo sapiens 208-212 25071412-5 2014 Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species. Superoxides 177-187 superoxide dismutase 2 Homo sapiens 0-30 25071412-5 2014 Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species. Superoxides 177-187 superoxide dismutase 2 Homo sapiens 32-37 24819633-2 2014 Manganese superoxide dismutase (SOD2) catalyses the dismutation of superoxide, regulates the metabolism of reactive oxygen species in the mitochondria and is highly expressed in the kidney. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-36 23588476-2 2014 The functional Ala-9Val polymorphism of the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which detoxifies superoxide radicals to hydrogen peroxide, has been associated with schizophrenia. Superoxides 75-85 superoxide dismutase 2 Homo sapiens 97-102 23581847-1 2014 SIGNIFICANCE: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to detoxify free radical O2( -) generated by mitochondrial respiration. Superoxides 200-202 superoxide dismutase 2 Homo sapiens 44-74 23581847-1 2014 SIGNIFICANCE: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to detoxify free radical O2( -) generated by mitochondrial respiration. Superoxides 200-202 superoxide dismutase 2 Homo sapiens 76-81 23581847-5 2014 These proteins modulate MnSOD superoxide scavenging activity via post-translational modifications in the mitochondria. Superoxides 30-40 superoxide dismutase 2 Homo sapiens 24-29 23590434-7 2014 The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption. Superoxides 100-110 superoxide dismutase 2 Homo sapiens 28-33 24567128-1 2014 Superoxide dismutases (SOD) are able to remove the superoxide anion free radicals produced by environmental stress and thereby protect cells from being injured by reactive oxygen species. Superoxides 51-67 superoxide dismutase 2 Homo sapiens 23-26 21899432-1 2011 Gene therapy-mediated overexpression of superoxide dismutases (SOD) appears to be a promising strategy for modulating radiosensitivity based on detoxification of superoxide radicals and suppression of apoptosis. Superoxides 162-181 superoxide dismutase 2 Homo sapiens 63-66 23727323-4 2013 Eukaryotic systems have evolved defenses against such damaging moieties, the chief member of which is superoxide dismutase (SOD2), an enzyme that efficiently converts superoxide to the less reactive hydrogen peroxide (H2O2), which can freely diffuse across the mitochondrial membrane. Superoxides 102-112 superoxide dismutase 2 Homo sapiens 124-128 23611775-2 2013 Down-regulation of the mitochondrial enzyme superoxide dismutase 2 (SOD2) contributes to the stabilization of HIF-1alpha under hypoxia due to the decreased dismutation of superoxide radical. Superoxides 171-189 superoxide dismutase 2 Homo sapiens 44-66 23611775-2 2013 Down-regulation of the mitochondrial enzyme superoxide dismutase 2 (SOD2) contributes to the stabilization of HIF-1alpha under hypoxia due to the decreased dismutation of superoxide radical. Superoxides 171-189 superoxide dismutase 2 Homo sapiens 68-72 23271813-1 2013 Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme responsible for the elimination of superoxide radical. Superoxides 99-117 superoxide dismutase 2 Homo sapiens 0-30 23271813-1 2013 Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme responsible for the elimination of superoxide radical. Superoxides 99-117 superoxide dismutase 2 Homo sapiens 32-37 22982047-1 2013 Manganese superoxide dismutase (MnSOD) is an integral mitochondrial protein known as a first-line antioxidant defense against superoxide radical anions produced as by-products of the electron transport chain. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 22561706-5 2012 The major antioxidant enzyme that scavenges superoxide anion radical in mitochondria is manganese superoxide dismutase (MnSOD). Superoxides 44-68 superoxide dismutase 2 Homo sapiens 88-118 22561706-5 2012 The major antioxidant enzyme that scavenges superoxide anion radical in mitochondria is manganese superoxide dismutase (MnSOD). Superoxides 44-68 superoxide dismutase 2 Homo sapiens 120-125 22547077-9 2012 One protein identified to be upregulated in the resistant cells was manganese superoxide dismutase (SOD2), a mitochondrial protein that converts superoxide radicals to hydrogen peroxides. Superoxides 78-88 superoxide dismutase 2 Homo sapiens 100-104 22406317-4 2012 Subsequent studies demonstrate that the electrotaxis of HT-1080 fibrosarcoma cells is abolished by NADPH oxidase inhibitor and overexpression of manganese superoxide dismutase (MnSOD), an enzyme that hydrolyzes superoxide. Superoxides 155-165 superoxide dismutase 2 Homo sapiens 177-182 22130631-1 2012 BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO). Superoxides 74-90 superoxide dismutase 2 Homo sapiens 26-56 22130631-1 2012 BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO). Superoxides 74-90 superoxide dismutase 2 Homo sapiens 58-63 21384152-9 2012 Results from spectroscopy assays indicate that HT in the presence of peroxidases can undergo catechol-semiquinone-quinone redox cycling generating superoxide, which in a cellular context can activate the antioxidant system, e.g., MnSOD expression. Superoxides 147-157 superoxide dismutase 2 Homo sapiens 230-235 22302046-6 2012 MitoSox(TM) Red assays showed that both lines of SOD2-expressing cells showed suppression of the superoxide generation in mitochondria. Superoxides 97-107 superoxide dismutase 2 Homo sapiens 49-53 22057568-6 2012 Superoxide dismutase (MnSOD, SOD2) from the mitochondrial matrix as well as superoxide dismutase (Cu/ZnSOD, SOD1) present in small amounts in the mitochondrial intramembrane space, convert superoxide anion to hydrogen peroxide, which can be then converted by catalase to harmless H(2)O. Superoxides 189-205 superoxide dismutase 2 Homo sapiens 22-27 22057568-6 2012 Superoxide dismutase (MnSOD, SOD2) from the mitochondrial matrix as well as superoxide dismutase (Cu/ZnSOD, SOD1) present in small amounts in the mitochondrial intramembrane space, convert superoxide anion to hydrogen peroxide, which can be then converted by catalase to harmless H(2)O. Superoxides 189-205 superoxide dismutase 2 Homo sapiens 29-33 22172488-5 2012 Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist. Superoxides 113-123 superoxide dismutase 2 Homo sapiens 74-77 22077216-1 2011 Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high concentrations of superoxide (O(2)(-)). Superoxides 100-110 superoxide dismutase 2 Homo sapiens 6-11 22077216-1 2011 Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high concentrations of superoxide (O(2)(-)). Superoxides 112-116 superoxide dismutase 2 Homo sapiens 6-11 22077216-10 2011 Our studies on yeast MnSODs indicate the unique nature of human MnSOD in that it predominantly undergoes the inhibited pathway at high [O(2)(-)]. Superoxides 136-140 superoxide dismutase 2 Homo sapiens 21-26 23566586-3 2013 Among the antioxidant enzymes, the manganese-dependent and mitochondria-specific isoform of SOD (MnSOD) represents the first line of defense against superoxide radicals attack. Superoxides 149-159 superoxide dismutase 2 Homo sapiens 59-95 23566586-3 2013 Among the antioxidant enzymes, the manganese-dependent and mitochondria-specific isoform of SOD (MnSOD) represents the first line of defense against superoxide radicals attack. Superoxides 149-159 superoxide dismutase 2 Homo sapiens 97-102 23880762-3 2013 The antioxidant enzyme superoxide dismutase (SOD) catalyzes the dismutation of highly reactive O2 (-) into H2O2 and thus acts as an intracellular generator of H2O2. Superoxides 95-101 superoxide dismutase 2 Homo sapiens 45-48 23880762-4 2013 As charged O2 (-) is unable to diffuse through intracellular membranes, cells express distinct SOD isoforms in the cytosol (Cu,Zn-SOD) and mitochondria (Mn-SOD), where they locally scavenge O2 (-) leading to production of H2O2. Superoxides 190-192 superoxide dismutase 2 Homo sapiens 95-98 23880762-4 2013 As charged O2 (-) is unable to diffuse through intracellular membranes, cells express distinct SOD isoforms in the cytosol (Cu,Zn-SOD) and mitochondria (Mn-SOD), where they locally scavenge O2 (-) leading to production of H2O2. Superoxides 190-192 superoxide dismutase 2 Homo sapiens 153-159 23429290-3 2013 In the present study, we observed that upon detachment from matrix, human mammary epithelial cells strongly upregulate manganese superoxide dismutase (MnSOD, or SOD2), a principal mitochondrial antioxidant enzyme that detoxifies ROS through dismutation of superoxide. Superoxides 129-139 superoxide dismutase 2 Homo sapiens 151-156 23429290-5 2013 Detachment of mammary epithelial cells potently increases mitochondrial superoxide levels, which are further elevated by depletion of MnSOD in suspended cells. Superoxides 72-82 superoxide dismutase 2 Homo sapiens 134-139 23429290-7 2013 These results suggest that detachment-induced MnSOD counters mitochondrial superoxide accumulation and confers anoikis resistance. Superoxides 75-85 superoxide dismutase 2 Homo sapiens 46-51 23000060-8 2012 These results provide evidence indicating that in addition to the enzymatic action of detoxifying superoxide, the antioxidant MnSOD may function as a signaling regulator in stress-induced adaptive protection through cell survival pathways. Superoxides 98-108 superoxide dismutase 2 Homo sapiens 126-131 22688013-2 2012 The superoxide dismutase manganese dependent (SOD2) catalyzes O(2)(-) in H(2)O(2) into mitochondria and is encoded by a single gene that presents a common polymorphism that results in the replacement of alanine (A) with a valine (V) in the 16 codon. Superoxides 62-66 superoxide dismutase 2 Homo sapiens 46-50 22836756-4 2012 We found that miR-21 inhibited the metabolism of superoxide to hydrogen peroxide, produced either by endogenous basal activities or exposure to ionizing radiation (IR), by directing attenuating SOD3 or by an indirect mechanism that limited TNFa production, thereby reducing SOD2 levels. Superoxides 49-59 superoxide dismutase 2 Homo sapiens 274-278 22710435-4 2012 Results from electron paramagnetic resonance spectroscopy and flow cytometric assays showed a significant increase in cellular superoxide levels in S-phase cells, which was associated with an increase in glucose and oxygen consumption, and a decrease in MnSOD activity. Superoxides 127-137 superoxide dismutase 2 Homo sapiens 254-259 22710435-8 2012 Methylation-dependent changes in the MnSOD conformation and subsequent changes in the electrostatic potential around the active site during quiescence versus proliferation could increase the accessibility of superoxide, a negatively charged substrate. Superoxides 208-218 superoxide dismutase 2 Homo sapiens 37-42 22218650-4 2012 Superoxide dismutase 2 (SOD2), at candidate modifier locus 6q25.3, detoxifies superoxide radicals protecting against oxidative stress and damage. Superoxides 78-97 superoxide dismutase 2 Homo sapiens 0-22 22218650-4 2012 Superoxide dismutase 2 (SOD2), at candidate modifier locus 6q25.3, detoxifies superoxide radicals protecting against oxidative stress and damage. Superoxides 78-97 superoxide dismutase 2 Homo sapiens 24-28 22469513-5 2012 Ectopic expression of mitochondrial superoxide scavenging enzyme (MnSOD) or treatment with MnSOD mimetic (MnTBAP) inhibited DOX-induced superoxide generation and apoptosis. Superoxides 36-46 superoxide dismutase 2 Homo sapiens 66-71 22469513-5 2012 Ectopic expression of mitochondrial superoxide scavenging enzyme (MnSOD) or treatment with MnSOD mimetic (MnTBAP) inhibited DOX-induced superoxide generation and apoptosis. Superoxides 136-146 superoxide dismutase 2 Homo sapiens 66-71 22469513-5 2012 Ectopic expression of mitochondrial superoxide scavenging enzyme (MnSOD) or treatment with MnSOD mimetic (MnTBAP) inhibited DOX-induced superoxide generation and apoptosis. Superoxides 136-146 superoxide dismutase 2 Homo sapiens 91-96 23080136-4 2012 Loss of HIF-2 activity leads to decreased transcription of the Sod2 gene, encoding manganese superoxide dismutase, which converts superoxide to hydrogen peroxide. Superoxides 93-103 superoxide dismutase 2 Homo sapiens 63-67 21899432-5 2011 A six- to eightfold increase in SOD activity was observed after transduction, rendering MnSOD-overexpressing TK6 cells significantly more resistant to paraquat-induced superoxide radical production than controls. Superoxides 168-186 superoxide dismutase 2 Homo sapiens 32-35 21899432-5 2011 A six- to eightfold increase in SOD activity was observed after transduction, rendering MnSOD-overexpressing TK6 cells significantly more resistant to paraquat-induced superoxide radical production than controls. Superoxides 168-186 superoxide dismutase 2 Homo sapiens 88-93 21167124-1 2011 Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2(. Superoxides 150-168 superoxide dismutase 2 Homo sapiens 0-30 20712406-4 2011 p53 orchestrates mitochondrial redox signaling by the coordinated control of at least two key effectors: the superoxide scavenger MnSOD, and the ROS generator p66shc. Superoxides 109-119 superoxide dismutase 2 Homo sapiens 130-135 21855229-10 2011 If the superoxide production is not effectively controlled by mitochondrial superoxide dismutase (Mn-SOD), then superoxide leads to OxS and lipid peroxidation. Superoxides 7-17 superoxide dismutase 2 Homo sapiens 62-96 21855229-10 2011 If the superoxide production is not effectively controlled by mitochondrial superoxide dismutase (Mn-SOD), then superoxide leads to OxS and lipid peroxidation. Superoxides 7-17 superoxide dismutase 2 Homo sapiens 98-104 21855229-10 2011 If the superoxide production is not effectively controlled by mitochondrial superoxide dismutase (Mn-SOD), then superoxide leads to OxS and lipid peroxidation. Superoxides 76-86 superoxide dismutase 2 Homo sapiens 98-104 21167124-1 2011 Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2(. Superoxides 150-168 superoxide dismutase 2 Homo sapiens 32-37 21167124-1 2011 Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2(. Superoxides 170-172 superoxide dismutase 2 Homo sapiens 0-30 21167124-1 2011 Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2(. Superoxides 170-172 superoxide dismutase 2 Homo sapiens 32-37 21150282-9 2011 In direct support of these findings, the tumor promoting effects of Cav-1 deficient fibroblasts could be functionally suppressed (nearly 2-fold) by the recombinant over-expression of SOD2 (superoxide dismutase 2), a known mitochondrial enzyme that de-activates superoxide, thereby reducing mitochondrial oxidative stress. Superoxides 189-199 superoxide dismutase 2 Homo sapiens 183-187 21056653-6 2011 Both MnSOD clones exhibit lower superoxide levels and higher H(2)O(2) levels. Superoxides 32-42 superoxide dismutase 2 Homo sapiens 5-10 21291402-5 2011 Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite. Superoxides 129-139 superoxide dismutase 2 Homo sapiens 49-54 21386137-3 2011 Manganese superoxide dismutase (MnSOD) is the primary mitochondrial ROS scavenging enzyme that converts superoxide to hydrogen peroxide, which is subsequently converted to water by catalase and other peroxidases. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 21355846-1 2011 Mitochondrial superoxide dismutase (MnSOD) neutralizes the highly reactive superoxide radical (O(2)( -)), the first member in a plethora of mitochondrial reactive oxygen species (ROS). Superoxides 75-93 superoxide dismutase 2 Homo sapiens 0-34 21355846-1 2011 Mitochondrial superoxide dismutase (MnSOD) neutralizes the highly reactive superoxide radical (O(2)( -)), the first member in a plethora of mitochondrial reactive oxygen species (ROS). Superoxides 75-93 superoxide dismutase 2 Homo sapiens 36-41 21355846-1 2011 Mitochondrial superoxide dismutase (MnSOD) neutralizes the highly reactive superoxide radical (O(2)( -)), the first member in a plethora of mitochondrial reactive oxygen species (ROS). Superoxides 95-99 superoxide dismutase 2 Homo sapiens 0-34 21355846-1 2011 Mitochondrial superoxide dismutase (MnSOD) neutralizes the highly reactive superoxide radical (O(2)( -)), the first member in a plethora of mitochondrial reactive oxygen species (ROS). Superoxides 95-99 superoxide dismutase 2 Homo sapiens 36-41 21080654-6 2010 Manganese superoxide dismutase (MnSOD), which plays a critical role in cellular defense against oxidative stress by decomposing superoxide within mitochondria, is nitrated and inactivated under pathological conditions. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 21175348-9 2011 SOD2 played an important role in the adaptive/delayed radioprotective response by inhibiting the initiation of a superoxide anion-induced ROS cascade leading to enhanced mitochondrial and nuclear damages. Superoxides 113-129 superoxide dismutase 2 Homo sapiens 0-4 20726524-1 2010 Manganese superoxide dismutase (MnSOD) from different species differs in its efficiency in removing high concentrations of superoxide (O(2)(-)), due to different levels of product inhibition. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 20685861-1 2010 CONTEXT: Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme in the mitochondria, protects cells by scavenging superoxide radicals in human endometrial stromal cells (ESCs). Superoxides 19-29 superoxide dismutase 2 Homo sapiens 41-47 20726524-1 2010 Manganese superoxide dismutase (MnSOD) from different species differs in its efficiency in removing high concentrations of superoxide (O(2)(-)), due to different levels of product inhibition. Superoxides 135-139 superoxide dismutase 2 Homo sapiens 0-30 20726524-1 2010 Manganese superoxide dismutase (MnSOD) from different species differs in its efficiency in removing high concentrations of superoxide (O(2)(-)), due to different levels of product inhibition. Superoxides 135-139 superoxide dismutase 2 Homo sapiens 32-37 20353787-2 2010 We further reveal that reactive oxygen species (ROS), especially superoxide radicals, play a crucial role in selenite-induced MnSOD upregulation, with extracellular regulated kinase (ERK) and p53 closely implicated. Superoxides 65-84 superoxide dismutase 2 Homo sapiens 126-131 20802415-2 2010 The first-line defense against oxidative stress is provided by the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which is a superoxide anion scavenger. Superoxides 139-155 superoxide dismutase 2 Homo sapiens 88-118 20802415-2 2010 The first-line defense against oxidative stress is provided by the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which is a superoxide anion scavenger. Superoxides 139-155 superoxide dismutase 2 Homo sapiens 120-125 20532186-4 2010 The purpose of this study was to determine if anticancer modalities known to produce superoxide radicals can increase the antitumor effect of MnSOD overexpression when combined with BCNU. Superoxides 85-95 superoxide dismutase 2 Homo sapiens 142-147 20012547-3 2010 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 23-53 20012547-3 2010 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 55-59 20059731-5 2010 Superoxide radicals produced are quickly scavenged by superoxide dismutase (MnSOD), and the resulting H(2)O(2) is detoxified by peroxiredoxin-thioredoxin system or by the enzymes of ascorbate-glutathione cycle, found in the mitochondrial matrix. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 76-81 20089930-5 2010 This response was significantly attenuated in neurons overexpressing the mitochondria-targeted O(2)(.-)-scavenging enzyme Mn-SOD. Superoxides 95-101 superoxide dismutase 2 Homo sapiens 122-128 20079425-9 2010 We propose that hypoxia induces superoxide accumulation in pulmonary artery myocytes through inhibition of mitochondrial SOD2 activity, promoting peroxynitrite-induced generation of 8-isoprostane. Superoxides 32-42 superoxide dismutase 2 Homo sapiens 121-125 20043000-2 2010 The mitochondrial superoxide dismutase 2 (SOD2) enzyme is critical in the metabolism of superoxide. Superoxides 18-28 superoxide dismutase 2 Homo sapiens 42-46 20204285-4 2010 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 23-53 20204285-4 2010 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 55-59 20088710-1 2010 Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. Superoxides 76-86 superoxide dismutase 2 Homo sapiens 129-134 20088710-7 2010 Inhibition of superoxide radicals by either MnTBAP or by over-expression of MnSOD prevented mtDNA damage and protected mitochondrial-encoded genes. Superoxides 14-24 superoxide dismutase 2 Homo sapiens 76-81 19262996-2 2009 Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. Superoxides 25-35 superoxide dismutase 2 Homo sapiens 184-189 19467856-2 2009 Manganese superoxide dismutase (MnSOD) is the major antioxidant in the mitochondria, catalysing the dismutation of superoxide radicals to form hydrogen peroxide. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 19731237-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron. Superoxides 48-64 superoxide dismutase 2 Homo sapiens 0-30 19731237-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron. Superoxides 48-64 superoxide dismutase 2 Homo sapiens 32-37 19666610-5 2009 We found that overexpression of SOD-2 decreased hippocampal superoxide, prevented AD-related learning and memory deficits, and reduced Abeta plaques. Superoxides 60-70 superoxide dismutase 2 Homo sapiens 32-37 20930427-8 2010 A defect of mitochondrial NDUFV1 may reduce complex I, which produces most of the superoxide, which is then scavenged by the mitochondrial enzyme Mn-superoxide dismutase to produce H(2)O(2). Superoxides 82-92 superoxide dismutase 2 Homo sapiens 146-169 19558795-4 2009 The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite. Superoxides 86-96 superoxide dismutase 2 Homo sapiens 46-51 19450565-5 2009 Protection by superoxide dismutase (Cu,Zn-SOD or Mn-SOD) or catalase indicates mediation of the toxicity by superoxide and hydrogen peroxide. Superoxides 14-24 superoxide dismutase 2 Homo sapiens 49-55 19558795-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. Superoxides 48-66 superoxide dismutase 2 Homo sapiens 0-30 19401447-2 2009 Elevating MnSOD levels in cells enhances the conversion of superoxide (O(2)(*-)) to hydrogen peroxide (H(2)O(2)), combined with inhibiting the removal of H(2)O(2), further increases H(2)O(2) levels, leading to increased cytotoxicity. Superoxides 59-69 superoxide dismutase 2 Homo sapiens 10-15 19558795-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. Superoxides 48-66 superoxide dismutase 2 Homo sapiens 32-37 19401447-2 2009 Elevating MnSOD levels in cells enhances the conversion of superoxide (O(2)(*-)) to hydrogen peroxide (H(2)O(2)), combined with inhibiting the removal of H(2)O(2), further increases H(2)O(2) levels, leading to increased cytotoxicity. Superoxides 71-75 superoxide dismutase 2 Homo sapiens 10-15 19401447-3 2009 We hypothesized that increasing endogenous O(2)(*-) production in cells that were pretreated with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) would lead to an increased level of intracellular H(2)O(2) accumulation and increased cell killing. Superoxides 43-47 superoxide dismutase 2 Homo sapiens 109-114 19306099-2 2009 We have studied fibroblasts stably overexpressing manganese superoxide dismutase (MnSOD) with a defined capacity for the removal of superoxide anions and concomitant accumulation of hydrogen peroxide to evaluate the role of enhanced MnSOD activity on the dynamics of cell-matrix interactions in the three-dimensional collagen lattice contraction assay. Superoxides 132-149 superoxide dismutase 2 Homo sapiens 50-80 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 0-10 superoxide dismutase 2 Homo sapiens 83-87 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 0-10 superoxide dismutase 2 Homo sapiens 113-143 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 0-10 superoxide dismutase 2 Homo sapiens 145-150 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 12-16 superoxide dismutase 2 Homo sapiens 83-87 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 12-16 superoxide dismutase 2 Homo sapiens 113-143 19265433-2 2009 Superoxide (O(2)(*-)) produced during respiration is removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD). Superoxides 12-16 superoxide dismutase 2 Homo sapiens 145-150 18379781-7 2009 CONCLUSIONS: This study demonstrates that selenite induces cell death and apoptosis by production of superoxide in mitochondria and activation of the mitochondrial apoptotic pathway and MnSOD plays an important role in protection against prooxidant effects of superoxide from selenite. Superoxides 260-270 superoxide dismutase 2 Homo sapiens 186-191 19064542-2 2008 Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O(*-)(2)), the first member in the plethora of mitochondrial reactive oxygen species. Superoxides 100-118 superoxide dismutase 2 Homo sapiens 41-54 18930813-3 2009 A search of publicly available microarray data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O(2)(-)) to hydrogen peroxide (H(2)O(2)), is consistently increased in high-grade and advanced-stage bladder tumors. Superoxides 98-108 superoxide dismutase 2 Homo sapiens 120-124 18930813-3 2009 A search of publicly available microarray data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O(2)(-)) to hydrogen peroxide (H(2)O(2)), is consistently increased in high-grade and advanced-stage bladder tumors. Superoxides 173-177 superoxide dismutase 2 Homo sapiens 120-124 18987137-8 2009 The induction of MnSOD expression was dependent on vFLIP/K13-mediated activation of NF-kappaB, occurred in a cell-intrinsic manner, and was correlated with decreased intracellular superoxide accumulation and increased resistance of endothelial cells to superoxide-induced death. Superoxides 180-190 superoxide dismutase 2 Homo sapiens 17-22 18987137-8 2009 The induction of MnSOD expression was dependent on vFLIP/K13-mediated activation of NF-kappaB, occurred in a cell-intrinsic manner, and was correlated with decreased intracellular superoxide accumulation and increased resistance of endothelial cells to superoxide-induced death. Superoxides 253-263 superoxide dismutase 2 Homo sapiens 17-22 19064542-2 2008 Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O(*-)(2)), the first member in the plethora of mitochondrial reactive oxygen species. Superoxides 100-118 superoxide dismutase 2 Homo sapiens 56-61 19064542-2 2008 Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O(*-)(2)), the first member in the plethora of mitochondrial reactive oxygen species. Superoxides 100-118 superoxide dismutase 2 Homo sapiens 66-70 18646267-3 2008 Manganese superoxide dismutase (MnSOD) is the only known superoxide scavenger in mitochondria. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 18594523-2 2008 Manganese superoxide disumutase (MnSOD) is an important antioxidant enzyme responsible for the elimination of superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 33-38 18594523-4 2008 Knockdown of MnSOD by small-interfering RNA (siRNA) led to an increase in superoxide generation and sensitisation of ovarian cancer cells to the two front-line anti-cancer agents doxorubicin and paclitaxel whose action involved free-radical generation. Superoxides 74-84 superoxide dismutase 2 Homo sapiens 13-18 18270969-7 2008 MnSOD is a key member of the mitochondrial defense system against mitochondrial-derived superoxide. Superoxides 88-98 superoxide dismutase 2 Homo sapiens 0-5 18281048-3 2008 Overexpression of the superoxide scavenger MnSOD and the hydrogen peroxide scavenger catalase inhibited tube formation in estrogen treated endothelial cells. Superoxides 22-32 superoxide dismutase 2 Homo sapiens 43-48 18413139-1 2008 Manganese superoxide dismutase (MnSOD) is the only primary antioxidant enzyme in mitochondria that scavenges superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 18247479-2 2008 As MnSOD has been shown to remove superoxide radical with varying efficiency depending upon its cellular origin, a comparison of the Drad MnSOD efficiency with that of both human and Escherichia coli MnSODs was undertaken. Superoxides 34-52 superoxide dismutase 2 Homo sapiens 3-8 18413745-3 2008 The antioxidant enzyme manganese superoxide dismutase (MnSOD) modulates the cellular redox environment by converting superoxide (O(2)(*-)) to hydrogen peroxide and dioxygen. Superoxides 33-43 superoxide dismutase 2 Homo sapiens 55-60 18247479-3 2008 Pulse radiolysis studies demonstrate that, under identical ratios of enzyme to superoxide radical, the dismutation efficiencies scaled as Drad MnSOD > E. coli MnSOD > human MnSOD. Superoxides 79-97 superoxide dismutase 2 Homo sapiens 143-148 18247479-3 2008 Pulse radiolysis studies demonstrate that, under identical ratios of enzyme to superoxide radical, the dismutation efficiencies scaled as Drad MnSOD > E. coli MnSOD > human MnSOD. Superoxides 79-97 superoxide dismutase 2 Homo sapiens 162-167 18247479-3 2008 Pulse radiolysis studies demonstrate that, under identical ratios of enzyme to superoxide radical, the dismutation efficiencies scaled as Drad MnSOD > E. coli MnSOD > human MnSOD. Superoxides 79-97 superoxide dismutase 2 Homo sapiens 162-167 18247479-4 2008 Further, Drad MnSOD is most effective at high superoxide fluxes found under conditions of high radioactivity. Superoxides 46-56 superoxide dismutase 2 Homo sapiens 14-19 18083891-6 2008 Superoxide dismutase 2 (SOD2) converts intramitochondrial superoxide to diffusible H(2)O(2), which serves as a redox-signaling molecule, regulating pulmonary vascular tone and structure through effects on Kv1.5 and transcription factors. Superoxides 58-68 superoxide dismutase 2 Homo sapiens 0-22 18083891-6 2008 Superoxide dismutase 2 (SOD2) converts intramitochondrial superoxide to diffusible H(2)O(2), which serves as a redox-signaling molecule, regulating pulmonary vascular tone and structure through effects on Kv1.5 and transcription factors. Superoxides 58-68 superoxide dismutase 2 Homo sapiens 24-28 17895890-1 2007 Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-36 18044968-6 2007 Moreover, the mechanism of this weakened product inhibition was similar to that in E. coli MnSOD, specifically a decrease in the rate constant for the oxidative addition of superoxide to Mn2+MnSOD leading to the formation of the peroxide-inhibited enzyme. Superoxides 173-183 superoxide dismutase 2 Homo sapiens 91-96 18044968-6 2007 Moreover, the mechanism of this weakened product inhibition was similar to that in E. coli MnSOD, specifically a decrease in the rate constant for the oxidative addition of superoxide to Mn2+MnSOD leading to the formation of the peroxide-inhibited enzyme. Superoxides 173-183 superoxide dismutase 2 Homo sapiens 191-196 18094428-5 2007 Increased SOD activity decreased superoxide levels and increased hydrogen peroxide levels. Superoxides 33-43 superoxide dismutase 2 Homo sapiens 10-13 18094428-8 2007 In contrast, inhibiting endogenous SOD with small interfering RNA increased superoxide levels and promoted tumor growth. Superoxides 76-86 superoxide dismutase 2 Homo sapiens 35-38 17854710-7 2007 Cells with mutant K-ras had significantly lower amounts of manganese superoxide dismutase (MnSOD) vs those with wild-type K-ras, but MnSOD protein correlated positively with superoxide levels. Superoxides 69-79 superoxide dismutase 2 Homo sapiens 91-96 17185981-0 2007 Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. Superoxides 41-51 superoxide dismutase 2 Homo sapiens 75-81 17394464-1 2007 Manganese superoxide dismutase (MnSOD) provides the first line of defense against superoxide generated in mitochondria. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 17394464-2 2007 SOD competes with nitric oxide for reaction with superoxide and prevents generation of peroxynitrite, a potent oxidant that can modify proteins to form 3-nitrotyrosine. Superoxides 49-59 superoxide dismutase 2 Homo sapiens 0-3 17296905-7 2007 RESULTS: Comparisons of AAV-SOD2-infected LHON cells relative to control cells infected with AAV-green fluorescent protein showed increased expression of mitochondrial SOD that attenuated superoxide-induced fluorescence by 26% (P = .003) and suppressed TUNEL-induced fluorescence by 21% (P = .048) after 2 days of growth in galactose medium, when cell survival increased by 25% (P=.05). Superoxides 188-198 superoxide dismutase 2 Homo sapiens 28-31 17851796-9 2007 Our findings also suggest that while plasma Mn-SOD might play a significant role in detoxifying the superoxide anions produced in the placenta, the decomposition of hydrogen peroxide in erythrocytes is mainly due to CAT activity. Superoxides 100-117 superoxide dismutase 2 Homo sapiens 44-50 17395009-1 2007 Human recombinant MnSOD and CuZnSOD were both inactivated when exposed to simultaneous fluxes of superoxide (JO(2)(*-)) and nitric oxide (J*NO). Superoxides 97-107 superoxide dismutase 2 Homo sapiens 18-23 17291583-5 2007 Antioxidant enzymes include two types of superoxide dismutase (SOD), which specifically scavenges superoxide radicals: copper-zinc SOD, which is located in the cytosol and Mn-SOD, which is located in the mitochondria. Superoxides 41-51 superoxide dismutase 2 Homo sapiens 172-178 17165602-4 2006 Manganese plays significant role in the free radical defense system as MnSOD, which protects the endothelial and red blood cells and mitochondria from the damage caused by superoxide radicals. Superoxides 172-182 superoxide dismutase 2 Homo sapiens 71-76 17211829-6 2007 Several proteins involved in defense against toxic superoxide (O2-) and other reactive oxygen species, such as manganese-containing superoxide dismutase (SOD2), glutathione peroxidase, and peroxiredoxins 1 and 6 were highly upregulated after TLR7/8 activation. Superoxides 51-61 superoxide dismutase 2 Homo sapiens 154-158 17916951-2 2007 Manganese (Mn), the key component of the Mitochondrial antioxidant (MnSOD), plays a key role in the superoxide uncoupling protein 2 (UCP-2) pathway in inhibiting of glucose-stimulated insulin secretion (GSIS). Superoxides 100-110 superoxide dismutase 2 Homo sapiens 68-73 17157182-1 2006 Manganese superoxide dismutase (MnSOD, SOD2) is an essential primary antioxidant enzyme which converts superoxide radical to hydrogen peroxide within the mitochondrial matrix. Superoxides 103-121 superoxide dismutase 2 Homo sapiens 0-30 17157182-1 2006 Manganese superoxide dismutase (MnSOD, SOD2) is an essential primary antioxidant enzyme which converts superoxide radical to hydrogen peroxide within the mitochondrial matrix. Superoxides 103-121 superoxide dismutase 2 Homo sapiens 32-37 17157182-1 2006 Manganese superoxide dismutase (MnSOD, SOD2) is an essential primary antioxidant enzyme which converts superoxide radical to hydrogen peroxide within the mitochondrial matrix. Superoxides 103-121 superoxide dismutase 2 Homo sapiens 39-43 17157182-11 2006 Our data indicate that inactivation of MnSOD in receptor-mediated apoptosis by caspase-specific degradation would render the mitochondria sensitive to the steady-state production of superoxide, decrease the steady-state flux of H(2)O(2), expedite the loss of mitochondrial function, and potentiate apoptosis. Superoxides 182-192 superoxide dismutase 2 Homo sapiens 39-44 16506247-3 2006 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 23-53 17015180-1 2006 The principal source of hydrogen peroxide in mitochondria is thought to be from the dismutation of superoxide via the enzyme manganese superoxide dismutase (MnSOD). Superoxides 99-109 superoxide dismutase 2 Homo sapiens 125-155 17015180-1 2006 The principal source of hydrogen peroxide in mitochondria is thought to be from the dismutation of superoxide via the enzyme manganese superoxide dismutase (MnSOD). Superoxides 99-109 superoxide dismutase 2 Homo sapiens 157-162 16814103-1 2006 We have studied the effects of overexpression of superoxide dismutase (SOD), a tumor suppressor protein that dismutes superoxide radical to H2O2, on breast cancer cell growth in vitro and xenograft growth in vivo. Superoxides 118-136 superoxide dismutase 2 Homo sapiens 71-74 16910769-4 2006 Because of its mitochondrial location, superoxide dismutase (SOD2) is the principal defense against the toxicity of superoxide anions generated by the oxidative phosphorylation. Superoxides 116-133 superoxide dismutase 2 Homo sapiens 61-65 16910769-6 2006 We became interested in the role SOD2 plays in the metabolism of superoxide anions during erythroid development, as anemia is the major phenotype in transplanted animals. Superoxides 65-82 superoxide dismutase 2 Homo sapiens 33-37 16769586-1 2006 Manganese superoxide dismutase (MnSOD) protects cells against oxidative stress by eliminating superoxides. Superoxides 94-105 superoxide dismutase 2 Homo sapiens 0-30 16769586-1 2006 Manganese superoxide dismutase (MnSOD) protects cells against oxidative stress by eliminating superoxides. Superoxides 94-105 superoxide dismutase 2 Homo sapiens 32-37 16506247-3 2006 The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide. Superoxides 94-111 superoxide dismutase 2 Homo sapiens 55-59 16458347-1 2006 INTRODUCTION AND OBJECTIVE: Manganese superoxide dismutase (MnSOD), an enzyme that catalyzes superoxide radical quenching, is hypothesized to protect against premature aging. Superoxides 38-48 superoxide dismutase 2 Homo sapiens 60-65 16412983-5 2006 Exogenously added catalase also protected cells from Cu[DEDTC]2, suggesting that this complex may kill after the levels of superoxide anion [O2*-] dismutated by MnSOD increase hydrogen peroxide-related stress. Superoxides 123-139 superoxide dismutase 2 Homo sapiens 161-166 16428241-7 2006 This important amount of Mn-SOD is a primary antioxidant defense system against superoxide radicals, but its product, H(2)O(2), is also deleterious for cells. Superoxides 80-90 superoxide dismutase 2 Homo sapiens 25-31 16412983-5 2006 Exogenously added catalase also protected cells from Cu[DEDTC]2, suggesting that this complex may kill after the levels of superoxide anion [O2*-] dismutated by MnSOD increase hydrogen peroxide-related stress. Superoxides 141-143 superoxide dismutase 2 Homo sapiens 161-166 16510607-1 2006 Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds. Superoxides 52-68 superoxide dismutase 2 Homo sapiens 32-37 16173037-12 2006 Superoxide is a by-product of selenite metabolism and normal cells showed increased MnSOD expression and SOD activity compared to the cancer-derived cells. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 84-89 16510607-1 2006 Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds. Superoxides 52-68 superoxide dismutase 2 Homo sapiens 0-30 16173037-12 2006 Superoxide is a by-product of selenite metabolism and normal cells showed increased MnSOD expression and SOD activity compared to the cancer-derived cells. Superoxides 0-10 superoxide dismutase 2 Homo sapiens 86-89 16173037-14 2006 CONCLUSIONS: Higher MnSOD expression in normal cells may play an important role in eliminating superoxide radicals produced as a result of selenite metabolism and contribute to the tumor-selective killing by selenite in prostate cancer. Superoxides 95-105 superoxide dismutase 2 Homo sapiens 20-25 16281056-1 2005 We have created P1 artificial chromosome transgenic mice expressing the human mitochondrial superoxide dismutase 2 (SOD2) and thus generated mice with a physiologically controlled augmentation of SOD2 expression leading to increased SOD2 enzyme activities and lowered superoxide levels. Superoxides 92-102 superoxide dismutase 2 Homo sapiens 116-120 16485861-2 2005 Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 16215873-2 2005 Manganese superoxide dismutase (MnSOD) is critical to management of oxidative stress by catalyzing the formation of hydrogen peroxide from two superoxide anions. Superoxides 143-160 superoxide dismutase 2 Homo sapiens 0-30 16215873-2 2005 Manganese superoxide dismutase (MnSOD) is critical to management of oxidative stress by catalyzing the formation of hydrogen peroxide from two superoxide anions. Superoxides 143-160 superoxide dismutase 2 Homo sapiens 32-37 16179351-2 2005 The manganese-containing SOD (Mn-SOD) has been suggested to have tumor suppressor function and is located in the mitochondria where the majority of O(2)(-) is generated during respiration. Superoxides 148-152 superoxide dismutase 2 Homo sapiens 4-28 16179351-2 2005 The manganese-containing SOD (Mn-SOD) has been suggested to have tumor suppressor function and is located in the mitochondria where the majority of O(2)(-) is generated during respiration. Superoxides 148-152 superoxide dismutase 2 Homo sapiens 30-36 16179351-6 2005 In experimental systems, suppression of Mn-SOD expression by small interfering RNA caused a 70% increase of superoxide in ovarian cancer cells, leading to stimulation of cell proliferation in vitro and more aggressive tumor growth in vivo. Superoxides 108-118 superoxide dismutase 2 Homo sapiens 40-46 16179351-7 2005 Furthermore, stimulation of mitochondrial O(2)(-) production induced an increase of Mn-SOD expression. Superoxides 42-49 superoxide dismutase 2 Homo sapiens 84-90 16179351-8 2005 Our findings suggest that the increase in Mn-SOD expression in ovarian cancer is a cellular response to intrinsic ROS stress and that scavenging of superoxide by SOD may alleviate the ROS stress and thus reduce the simulating effect of ROS on cell growth. Superoxides 148-158 superoxide dismutase 2 Homo sapiens 42-48 15894290-2 2005 Since PDT with the photosensitizer phthalocyanine Pc 4 induces mitochondrial damage and the superoxide scavenger manganese superoxide dismutase (MnSOD) is localized to mitochondria, here we tested genetically the role of MnSOD in apoptosis and ceramide accumulation after photosensitization with Pc 4. Superoxides 92-102 superoxide dismutase 2 Homo sapiens 113-143 15817612-11 2005 Compared with control cells, MnSOD-expressing DLD-1 POX cells generated a higher concentration of H2O2 owing to dismutation of superoxide radicals, which was elevated by POX. Superoxides 127-137 superoxide dismutase 2 Homo sapiens 29-34 15817612-12 2005 Thus, these data further suggest that the generation of superoxide radicals plays a crucial role in POX-induced apoptosis and the process is partially blocked by MnSOD. Superoxides 56-75 superoxide dismutase 2 Homo sapiens 162-167 16024627-3 2005 Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme encoded by the SOD2 gene that attenuates oxidative free radicals in the mitochondria by catalyzing the formation of hydrogen peroxide from superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 16024627-3 2005 Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme encoded by the SOD2 gene that attenuates oxidative free radicals in the mitochondria by catalyzing the formation of hydrogen peroxide from superoxide radicals. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 89-93 15894290-2 2005 Since PDT with the photosensitizer phthalocyanine Pc 4 induces mitochondrial damage and the superoxide scavenger manganese superoxide dismutase (MnSOD) is localized to mitochondria, here we tested genetically the role of MnSOD in apoptosis and ceramide accumulation after photosensitization with Pc 4. Superoxides 92-102 superoxide dismutase 2 Homo sapiens 145-150 15894290-6 2005 The data show that MnSOD affects sensitivity of cells to Pc 4-PDT-initiated apoptosis, and partly ceramide accumulation, suggesting that the processes are superoxide-mediated. Superoxides 155-165 superoxide dismutase 2 Homo sapiens 19-24 15883815-4 2005 A polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of the MnSOD gene has been proposed to affect protein localization and thereby influence cellular defence against superoxide radicals. Superoxides 186-196 superoxide dismutase 2 Homo sapiens 79-84 15516670-3 2004 Superoxide dismutases (SOD)s are the only enzymes capable of consuming superoxide radicals. Superoxides 71-81 superoxide dismutase 2 Homo sapiens 23-26 15867370-5 2005 In the mitochondria, p53 interacts with the primary antioxidant enzyme, manganese superoxide dismutase (MnSOD), consistent with the reduction of its superoxide scavenging activity, and a subsequent decrease of mitochondrial membrane potential. Superoxides 82-92 superoxide dismutase 2 Homo sapiens 104-109 15610954-2 2005 The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Superoxides 57-67 superoxide dismutase 2 Homo sapiens 99-129 15610954-2 2005 The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Superoxides 57-67 superoxide dismutase 2 Homo sapiens 131-137 15534883-2 2004 Manganese superoxide dismutase (SOD2) catalyzes the dismutation of superoxide radicals, a major type of ROS, into hydrogen peroxide. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-36 15205258-1 2004 SOD2 is an antioxidant protein that protects cells against mitochondrial superoxide. Superoxides 73-83 superoxide dismutase 2 Homo sapiens 0-4 15205258-6 2004 Fluorescence-activated cell sorting (FACS) analysis of cells labeled with oxidation-sensitive dyes demonstrates enhanced production of superoxide and hydrogen peroxide by SOD2-deficient cells. Superoxides 135-145 superoxide dismutase 2 Homo sapiens 171-175 15451059-2 2004 Here we show that a tris-malonic acid derivative of the fullerene C60 molecule (C3) is capable of removing the biologically important superoxide radical with a rate constant (k(C3)) of 2 x 10(6) mol(-1) s(-1), approximately 100-fold slower than the superoxide dismutases (SOD), a family of enzymes responsible for endogenous dismutation of superoxide. Superoxides 134-144 superoxide dismutase 2 Homo sapiens 272-275 15451059-2 2004 Here we show that a tris-malonic acid derivative of the fullerene C60 molecule (C3) is capable of removing the biologically important superoxide radical with a rate constant (k(C3)) of 2 x 10(6) mol(-1) s(-1), approximately 100-fold slower than the superoxide dismutases (SOD), a family of enzymes responsible for endogenous dismutation of superoxide. Superoxides 249-259 superoxide dismutase 2 Homo sapiens 272-275 15512801-6 2004 Since MnSOD removes superoxide, these results suggest that superoxide free radical or its reaction products are responsible for part of the cytotoxicity associated with hyperthermia and that MnSOD can reduce cellular injury and thereby enhance heat tolerance. Superoxides 20-30 superoxide dismutase 2 Homo sapiens 6-11 15512801-6 2004 Since MnSOD removes superoxide, these results suggest that superoxide free radical or its reaction products are responsible for part of the cytotoxicity associated with hyperthermia and that MnSOD can reduce cellular injury and thereby enhance heat tolerance. Superoxides 59-69 superoxide dismutase 2 Homo sapiens 6-11 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Superoxides 121-139 superoxide dismutase 2 Homo sapiens 66-96 15554245-7 2004 From the results reviewed here, two schemes for the involvement of MnSOD and catalase in the regulation of apoptosis can be extracted: 1) Both MnSOD and catalase inhibit apoptosis by removing superoxide anion radicals or H2O2, respectively, because these reactive oxygen species are mediators required for the apoptotic program or inhibit a survival pathway. Superoxides 192-217 superoxide dismutase 2 Homo sapiens 67-72 15554245-7 2004 From the results reviewed here, two schemes for the involvement of MnSOD and catalase in the regulation of apoptosis can be extracted: 1) Both MnSOD and catalase inhibit apoptosis by removing superoxide anion radicals or H2O2, respectively, because these reactive oxygen species are mediators required for the apoptotic program or inhibit a survival pathway. Superoxides 192-217 superoxide dismutase 2 Homo sapiens 143-148 14688256-2 2004 Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2). Superoxides 85-95 superoxide dismutase 2 Homo sapiens 0-6 14688256-2 2004 Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2). Superoxides 106-110 superoxide dismutase 2 Homo sapiens 0-6 14688256-2 2004 Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2). Superoxides 118-122 superoxide dismutase 2 Homo sapiens 0-6 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Superoxides 141-145 superoxide dismutase 2 Homo sapiens 66-96 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Superoxides 141-145 superoxide dismutase 2 Homo sapiens 98-103 15777015-1 2004 The release of cytochrome c from mitochondria during apoptosis results in the enhanced production of superoxide radicals, which are converted to H2O2 by Mn-superoxide dismutase. Superoxides 101-120 superoxide dismutase 2 Homo sapiens 153-176 15517870-8 2004 In addition, over expression of the human SOD2 gene (MnSOD) inhibited NF-kappaB and pGL3CB1EI1 activity, indicating that superoxide or some species derived from superoxide may have participated in the up-regulation of reporter activity in response to chronic exposure to fractionated ionizing radiation. Superoxides 121-131 superoxide dismutase 2 Homo sapiens 42-46 15517870-8 2004 In addition, over expression of the human SOD2 gene (MnSOD) inhibited NF-kappaB and pGL3CB1EI1 activity, indicating that superoxide or some species derived from superoxide may have participated in the up-regulation of reporter activity in response to chronic exposure to fractionated ionizing radiation. Superoxides 121-131 superoxide dismutase 2 Homo sapiens 53-58 15517870-8 2004 In addition, over expression of the human SOD2 gene (MnSOD) inhibited NF-kappaB and pGL3CB1EI1 activity, indicating that superoxide or some species derived from superoxide may have participated in the up-regulation of reporter activity in response to chronic exposure to fractionated ionizing radiation. Superoxides 161-171 superoxide dismutase 2 Homo sapiens 42-46 15517870-8 2004 In addition, over expression of the human SOD2 gene (MnSOD) inhibited NF-kappaB and pGL3CB1EI1 activity, indicating that superoxide or some species derived from superoxide may have participated in the up-regulation of reporter activity in response to chronic exposure to fractionated ionizing radiation. Superoxides 161-171 superoxide dismutase 2 Homo sapiens 53-58 15305022-1 2004 Manganese superoxide dismutase (MnSOD) is an antioxidative enzyme that scavenges superoxide radicals and is localized in the mitochondrial matrix. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 15130279-2 2004 Manganese superoxide dismutase (MnSOD) is a nuclear-encoded mitochondrial enzyme, which scavenges superoxide generated from the electron-transport chain in mitochondria. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 15051313-4 2004 A network of intramitochondrial antioxidants consisting of the enzymes Mn-superoxide dismutase and glutathione peroxidase and of the reductants NADH(2), ubiquinol and reduced glutathione, is operative in minimizing the potentially harmful effects of O(2)(-), NO, H(2)O(2) and ONOO(-). Superoxides 250-254 superoxide dismutase 2 Homo sapiens 71-94 15018733-1 2004 Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into water. Superoxides 121-139 superoxide dismutase 2 Homo sapiens 98-103 12627943-1 2003 Catalysis of the disproportionation of superoxide by human manganese superoxide dismutase (MnSOD) is characterized by an initial burst of catalysis followed by a much slower region that is zero order in superoxide and due to a product inhibition by peroxide anion. Superoxides 39-49 superoxide dismutase 2 Homo sapiens 59-89 14503839-3 2003 We hypothesized that the inducibility of Mn-SOD and MT mRNA by paraquat, an intracellular superoxide generator, might be altered in lymphocytes of gastric cancer patients. Superoxides 90-100 superoxide dismutase 2 Homo sapiens 41-47 12862482-1 2003 Mn-superoxide dismutase (Mn-SOD), which protects the cell from the toxic potential of superoxide radicals (O(2)(-*)), is the only type of SOD which resides in eukaryotic mitochondria. Superoxides 3-13 superoxide dismutase 2 Homo sapiens 25-31 12862482-1 2003 Mn-superoxide dismutase (Mn-SOD), which protects the cell from the toxic potential of superoxide radicals (O(2)(-*)), is the only type of SOD which resides in eukaryotic mitochondria. Superoxides 3-13 superoxide dismutase 2 Homo sapiens 28-31 12862482-18 2003 Similar coordination and stabilization of the (*)OOH radical by the Mn center may be key steps in the enzymatic dismutation of superoxide radicals by Mn-SOD. Superoxides 127-137 superoxide dismutase 2 Homo sapiens 150-156 12627943-1 2003 Catalysis of the disproportionation of superoxide by human manganese superoxide dismutase (MnSOD) is characterized by an initial burst of catalysis followed by a much slower region that is zero order in superoxide and due to a product inhibition by peroxide anion. Superoxides 39-49 superoxide dismutase 2 Homo sapiens 91-96 12627943-1 2003 Catalysis of the disproportionation of superoxide by human manganese superoxide dismutase (MnSOD) is characterized by an initial burst of catalysis followed by a much slower region that is zero order in superoxide and due to a product inhibition by peroxide anion. Superoxides 69-79 superoxide dismutase 2 Homo sapiens 91-96 12627943-3 2003 Using pulse radiolysis to generate superoxide, we have determined that kcat/K(m) was decreased and product inhibition increased for H30V MnSOD, both by 1-2 orders of magnitude, compared with wild type, H30N, and H30Q MnSOD. Superoxides 35-45 superoxide dismutase 2 Homo sapiens 137-142 12426235-3 2002 We tested whether overexpression of MnSOD could decrease superoxide levels and protect the bladder from radiation damage. Superoxides 57-67 superoxide dismutase 2 Homo sapiens 36-41 12388080-1 2003 Manganese superoxide dismutase (MnSOD) is a critical antioxidant enzyme that protects against superoxide anion generated as a consequence of normal cellular respiration, as well as during the inflammatory response. Superoxides 94-110 superoxide dismutase 2 Homo sapiens 0-30 12388080-1 2003 Manganese superoxide dismutase (MnSOD) is a critical antioxidant enzyme that protects against superoxide anion generated as a consequence of normal cellular respiration, as well as during the inflammatory response. Superoxides 94-110 superoxide dismutase 2 Homo sapiens 32-37 12496360-1 2002 Manganese superoxide dismutase (MnSOD) catalyzes the dismutation of superoxide anions (O(2)(-)) into hydrogen peroxide (H(2)O(2)). Superoxides 68-85 superoxide dismutase 2 Homo sapiens 0-30 12496360-1 2002 Manganese superoxide dismutase (MnSOD) catalyzes the dismutation of superoxide anions (O(2)(-)) into hydrogen peroxide (H(2)O(2)). Superoxides 68-85 superoxide dismutase 2 Homo sapiens 32-37 12496360-1 2002 Manganese superoxide dismutase (MnSOD) catalyzes the dismutation of superoxide anions (O(2)(-)) into hydrogen peroxide (H(2)O(2)). Superoxides 87-91 superoxide dismutase 2 Homo sapiens 0-30 12496360-1 2002 Manganese superoxide dismutase (MnSOD) catalyzes the dismutation of superoxide anions (O(2)(-)) into hydrogen peroxide (H(2)O(2)). Superoxides 87-91 superoxide dismutase 2 Homo sapiens 32-37 12031898-7 2002 Further investigations into the mechanisms by which AA induced MnSOD expression showed that superoxide anions released from AA metabolism act as second messengers via a signal-controlling pathway involving protein kinase C and p38 mitogen activated protein kinase (MAPK). Superoxides 92-109 superoxide dismutase 2 Homo sapiens 63-68 12469142-1 2003 Manganese superoxide dismutase (MnSOD) is an important superoxide anion scavenger located in mitochondria and protects cells from the damage caused by reactive oxygen species. Superoxides 55-71 superoxide dismutase 2 Homo sapiens 0-30 12469142-1 2003 Manganese superoxide dismutase (MnSOD) is an important superoxide anion scavenger located in mitochondria and protects cells from the damage caused by reactive oxygen species. Superoxides 55-71 superoxide dismutase 2 Homo sapiens 32-37 12127599-2 2002 The manganese-containing form of this enzyme (MnSOD) is the major superoxide scavenger in mitochondria; a weak association between a functional genetic polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of this enzyme and TD has been reported in a Japanese population. Superoxides 66-76 superoxide dismutase 2 Homo sapiens 46-51 11761717-6 2001 Together with the fact that nitric oxide (NO) plays a potential role in neuronal differentiation, and that large amounts of NO have cytotoxicity from the reaction of NO with superoxide anions, our data suggested that the expressions of both SOD1 and SOD2, as scavengers of superoxide anions, were maintained from an early developmental stage to prepare stage-specific nNOS expression for a potential differentiation role and to elude NO cytotoxicity. Superoxides 174-191 superoxide dismutase 2 Homo sapiens 250-254 12269769-1 2002 The purpose of this study was to examine whether the increased sensitivity of cancer cells to adriamycin (ADM), which is known to produce superoxide radicals, was brought through suppressed manganese superoxide disumutase (MnSOD) expression in the presence of transforming growth factor beta1 (TGFbeta1). Superoxides 138-148 superoxide dismutase 2 Homo sapiens 223-228 11912930-1 2002 Measurement of catalysis by MnSOD using direct observation of the UV absorbance of superoxide allows determination of steady-state catalytic constants. Superoxides 83-93 superoxide dismutase 2 Homo sapiens 28-33 11912930-3 2002 Studies show that kcat/Km for the decay of superoxide catalyzed by MnSOD proceeds at diffusion control. Superoxides 43-53 superoxide dismutase 2 Homo sapiens 67-72 11709424-5 2001 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides 31-41 superoxide dismutase 2 Homo sapiens 206-236 11709424-5 2001 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides 31-41 superoxide dismutase 2 Homo sapiens 238-243 11761717-6 2001 Together with the fact that nitric oxide (NO) plays a potential role in neuronal differentiation, and that large amounts of NO have cytotoxicity from the reaction of NO with superoxide anions, our data suggested that the expressions of both SOD1 and SOD2, as scavengers of superoxide anions, were maintained from an early developmental stage to prepare stage-specific nNOS expression for a potential differentiation role and to elude NO cytotoxicity. Superoxides 174-184 superoxide dismutase 2 Homo sapiens 250-254 11580280-1 2001 Manganese superoxide dismutase (MnSOD) cycles between the Mn(II) and Mn(III) states during the catalyzed disproportionation of O(2)(*-), a catalysis that is limited at micromolar levels of superoxide by a peroxide-inhibited complex with the metal. Superoxides 127-131 superoxide dismutase 2 Homo sapiens 0-30 11580280-1 2001 Manganese superoxide dismutase (MnSOD) cycles between the Mn(II) and Mn(III) states during the catalyzed disproportionation of O(2)(*-), a catalysis that is limited at micromolar levels of superoxide by a peroxide-inhibited complex with the metal. Superoxides 127-131 superoxide dismutase 2 Homo sapiens 32-37 11580280-1 2001 Manganese superoxide dismutase (MnSOD) cycles between the Mn(II) and Mn(III) states during the catalyzed disproportionation of O(2)(*-), a catalysis that is limited at micromolar levels of superoxide by a peroxide-inhibited complex with the metal. Superoxides 10-20 superoxide dismutase 2 Homo sapiens 32-37 11580280-6 2001 Catalysis by W161A and W161F MnSOD was associated with a decrease of at least 100-fold in the catalytic rate of reduction of superoxide, which then promotes a competing pathway leading to product inhibition. Superoxides 125-135 superoxide dismutase 2 Homo sapiens 29-34 20954153-3 2001 Activity can be measured as described in this unit by a number of indirect competitive inhibition assays based on the principle that the superoxide anion radical will reduce an inhibitory substrate [such as nitroblue tetrazolium (NBT) or cytochrome c] and SOD activity will reduce the rate of reduction in a competitive fashion. Superoxides 137-161 superoxide dismutase 2 Homo sapiens 256-259 11529760-5 2001 The pH-dependent role of superoxide was probed using Mn-SOD and compared to guanosine and 8-methoxyguanosine photooxidation. Superoxides 25-35 superoxide dismutase 2 Homo sapiens 53-59 11592093-1 2001 Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme capable of neutralizing superoxide anion molecules. Superoxides 88-104 superoxide dismutase 2 Homo sapiens 0-30 11592093-1 2001 Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme capable of neutralizing superoxide anion molecules. Superoxides 88-104 superoxide dismutase 2 Homo sapiens 32-37 11555836-2 2001 Manganese (Mn)(2+)-dependent superoxide dismutase (SOD-2) is primarily responsible for metabolism of superoxide produced in mitochondria by respiratory chain activity during aerobic metabolism of glucose and other substrates. Superoxides 29-39 superoxide dismutase 2 Homo sapiens 51-56