PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23608466-0	2013	Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells.	Superoxides	14-24	TNF superfamily member 10	Homo sapiens	90-95	
23608466-1	2013	Reactive oxygen species (ROS), such as superoxide (O2( -)) and hydrogen peroxide (H2O2), have been reported to be important mediators of the apoptosis induced by death ligands, including Fas, tumor necrosis factor-alpha, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Superoxides	39-49	TNF superfamily member 10	Homo sapiens	225-280	
23608466-1	2013	Reactive oxygen species (ROS), such as superoxide (O2( -)) and hydrogen peroxide (H2O2), have been reported to be important mediators of the apoptosis induced by death ligands, including Fas, tumor necrosis factor-alpha, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Superoxides	39-49	TNF superfamily member 10	Homo sapiens	282-287	
23608466-1	2013	Reactive oxygen species (ROS), such as superoxide (O2( -)) and hydrogen peroxide (H2O2), have been reported to be important mediators of the apoptosis induced by death ligands, including Fas, tumor necrosis factor-alpha, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Superoxides	51-53	TNF superfamily member 10	Homo sapiens	225-280	
23608466-1	2013	Reactive oxygen species (ROS), such as superoxide (O2( -)) and hydrogen peroxide (H2O2), have been reported to be important mediators of the apoptosis induced by death ligands, including Fas, tumor necrosis factor-alpha, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Superoxides	51-53	TNF superfamily member 10	Homo sapiens	282-287	
23608466-6	2013	TRAIL treatment resulted in increased mitochondrial O2( -) generation and the oxidation of cardiolipin.	Superoxides	52-54	TNF superfamily member 10	Homo sapiens	0-5	
23608466-7	2013	The O2( -)-selective scavenger MnTBaP [Mn(III) tetrakis (4-benzoic acid) porphyrin chloride] specifically blocked TRAIL-induced apoptosis and proapoptotic events including mitochondrial membrane collapse and caspase-3/7 activation.	Superoxides	4-10	TNF superfamily member 10	Homo sapiens	114-119	
23608466-9	2013	In addition, increased mitochondrial O2( -) generation by uncoupling of oxidative phosphorylation or inhibition of the electron transport chain amplified the TRAIL-induced apoptosis and proapoptotic events.	Superoxides	37-39	TNF superfamily member 10	Homo sapiens	158-163	
23608466-11	2013	Our data indicate that mitochondrial O2( -) mediates mitochondrial and ER dysfunctions during TRAIL-induced apoptosis in Jurkat cells.	Superoxides	37-39	TNF superfamily member 10	Homo sapiens	94-99	
23608466-12	2013	The present findings suggest that pharmacological agents increasing mitochondrial O2( -) may serve as clinical drugs that amplify TRAIL effectiveness toward cancer cells.	Superoxides	82-84	TNF superfamily member 10	Homo sapiens	130-135	
21418589-0	2011	The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells.	Superoxides	18-28	TNF superfamily member 10	Homo sapiens	124-179	
23314732-0	2013	Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma             through intracellular superoxide generation.	Superoxides	105-115	TNF superfamily member 10	Homo sapiens	46-51	
23314732-3	2013	Here, we show that exogenously applied H(2)O(2) (30-100 microM) induces cell death in TRAIL-resistant human melanoma cells via intracellular superoxide (O(2)-) generation.	Superoxides	141-151	TNF superfamily member 10	Homo sapiens	86-91	
23314732-3	2013	Here, we show that exogenously applied H(2)O(2) (30-100 microM) induces cell death in TRAIL-resistant human melanoma cells via intracellular superoxide (O(2)-) generation.	Superoxides	43-47	TNF superfamily member 10	Homo sapiens	86-91	
21418589-5	2011	The decrease in cellular O2-, which was accompanied by a brief accumulation of H2O2 and downregulation of phosphorylated Akt (p-Akt) and cellular FLICE-inhibitory protein, sensitized K562 leukemia cells and human promyelocytic leukemia (HL-60) cells to TRAIL-induced apoptosis.	Superoxides	25-27	TNF superfamily member 10	Homo sapiens	253-258	
16891474-0	2006	Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.	Superoxides	87-97	TNF superfamily member 10	Homo sapiens	55-60