PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27329107-9 2016 Exploring the underlying mechanisms showed that alpha-Syn (29-40) peptide triggered Nox2 to generate extracellular superoxide and its metabolite H2O2 by binding to the catalytic unit gp91 (phox) of Nox2; diffusing into cytosol, H2O2 activated Erk1/2 kinase to phosphorylate p47 (phox) and p67 (phox) and further activated Nox2, establishing a positive feedback loop to amplify the Nox2-mediated response. Superoxides 115-125 methionine aminopeptidase 2 Mus musculus 289-292 21966644-7 2011 RESULTS: Superoxide levels increased 1.4-fold in the muscle of mice with cancer cachexia, and this was associated with a decrease in mRNA of NOX enzyme subunits, NOX2, p40(phox) and p67(phox) along with the antioxidant enzymes SOD1, SOD2 and GPx. Superoxides 9-19 methionine aminopeptidase 2 Mus musculus 182-185