PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32010784-3 2020 Although CD11b+Gr-1+Sca-1+ cells have impaired migratory capacity and superoxide anion-producing activity, they secrete increased levels of several cytokines and chemokines compared to Sca-1- counterparts. Superoxides 70-86 integrin subunit alpha M Homo sapiens 9-14 31907993-7 2020 Importantly, we show that selective targeting of glycans on CD11b with such lectins results in altered intracellular signaling events that inhibit TEpM and differentially affect key PMN inflammatory functions including phagocytosis, superoxide release and apoptosis. Superoxides 233-243 integrin subunit alpha M Homo sapiens 60-65 12215485-3 2002 LNO2, but not linoleic acid or the nitrated amino acid 3-nitrotyrosine, dose-dependently (0.2 to 1 micromol/L) inhibited superoxide (O2*-) generation, Ca2+ influx, elastase release, and CD11b expression in response to either phorbol 12-myristate 13-acetate or N-formyl-Met-Leu-Phe. Superoxides 2-4 integrin subunit alpha M Homo sapiens 186-191 25420684-7 2015 HLA-DR(+)CD11b(+)CD11c(+)CD163(-) superoxide-producing MDRCs, which stimulated proliferation of autologous T cells, comprised a high fraction of MDRCs in the airways of patients with mild asthma or COPD but not those of healthy control subjects. Superoxides 34-44 integrin subunit alpha M Homo sapiens 9-14 12689660-11 2003 CD11b(+)Gr-1(+) cells isolated from the blood or spleen of TCDD-treated mice produced up to fivefold higher levels of superoxide following PMA stimulation when compared with cells from vehicle-treated mice. Superoxides 118-128 integrin subunit alpha M Homo sapiens 0-5 29154191-5 2018 The involvement of CD11b in alpha-synuclein-induced activation of NOX2 was further confirmed in CD11b-/- microglia by showing reduced membrane translocation of NOX2 cytosolic subunit p47phox and superoxide production. Superoxides 195-205 integrin subunit alpha M Homo sapiens 19-24 26819958-8 2015 Moreover, heparin caused a significant dose-dependent decrease in the rate of superoxide release from PMNLs, which was blunted by blocking antibodies to CD11b. Superoxides 78-88 integrin subunit alpha M Homo sapiens 153-158 23324884-6 2013 Compared with the response of preoperative PMNs, PMNs assayed on days 3 and 5 after OPCAB demonstrated a significantly blunted increase in the expression of CD11b and CBRM1/5 after fMLF, significantly diminished shedding of CD62L in response to platelet-activating factor and fMLF, and diminished superoxide production after stimulation on day 3. Superoxides 297-307 integrin subunit alpha M Homo sapiens 157-162 21193407-12 2011 Stimulation with NB1-activating mAb triggered degranulation and superoxide production in mNB1(pos)/mPR3(high) neutrophils, and this effect was reduced using blocking antibodies to CD11b. Superoxides 64-74 integrin subunit alpha M Homo sapiens 180-185 15625114-9 2005 MPO also augmented PMN-dependent superoxide (O(2)(*-)) production, which was prevented by anti-CD11b antibodies, but not MPO inhibitors. Superoxides 33-43 integrin subunit alpha M Homo sapiens 95-100 15625114-9 2005 MPO also augmented PMN-dependent superoxide (O(2)(*-)) production, which was prevented by anti-CD11b antibodies, but not MPO inhibitors. Superoxides 45-53 integrin subunit alpha M Homo sapiens 95-100 10578126-3 1999 3 PP1, an inhibitor of the src-family of protein tyrosine kinases, inhibited adhesion and CD11b/CD18-mediated superoxide anion generation with similar potencies (pEC50s=-5.53 and -5.99 respectively) suggesting that inhibition of the NADPH oxidase was a direct consequence of blocking adhesion. Superoxides 110-126 integrin subunit alpha M Homo sapiens 90-95 10873967-5 2000 Superoxide anion production (respiratory burst) was determined by lucigenin enhanced chemiluminescence (LUCL); secondary granule lactoferrin release by enzyme linked immunosorbent assay (ELISA); and CD11b, CD18, and CD62L expression by flow cytometric analysis. Superoxides 0-16 integrin subunit alpha M Homo sapiens 199-204 8028050-6 1994 Superoxide production was measured by cytochrome c reduction, PMN-EC adhesion with indium-labelled PMN adherence to human umbilical vein endothelial cell (HUVEC) monolayer cultures, and CD11B expression with fluorescent labelled anti-CD11B (60.1) antibodies. Superoxides 0-10 integrin subunit alpha M Homo sapiens 234-239 9291376-5 1997 Our hypothesis is that the well-recognized postinjury mediators platelet-activating factor (PAF) and leukotriene B4 (LTB4) prime PMNs for the concordant release of elastase and superoxide (O2-) as well as for CD11b up-regulation. Superoxides 177-187 integrin subunit alpha M Homo sapiens 209-214 9291376-5 1997 Our hypothesis is that the well-recognized postinjury mediators platelet-activating factor (PAF) and leukotriene B4 (LTB4) prime PMNs for the concordant release of elastase and superoxide (O2-) as well as for CD11b up-regulation. Superoxides 189-191 integrin subunit alpha M Homo sapiens 209-214 9071927-8 1997 Isolated cells obtained from the oesophageal mucosa after acidified pepsin exposure generated increased amounts of superoxide anions, which were mainly produced by CD11b positive cells. Superoxides 115-132 integrin subunit alpha M Homo sapiens 164-169 7532664-4 1995 Cross-linking of Mac-1 molecules with mAb also induced significant changes in [Ca2+]i levels and O2- generation by neutrophils, which was also dependent on the epitope binding by mAb. Superoxides 97-99 integrin subunit alpha M Homo sapiens 17-22 7532664-7 1995 The data indicate that cross-linking of L-selectin and Mac-1 initiates changes in [Ca2+]i and O2- production in neutrophils and suggest that these distinct adhesion molecules independently may play important regulatory roles in modulating neutrophil-endothelial cell interactions, transmigration, and neutrophil function at sites of tissue injury. Superoxides 94-96 integrin subunit alpha M Homo sapiens 55-60 7514638-12 1994 These results indicate that CD11b/CD18 (Mac-1)-dependent cellular adhesion plays an important role in the degranulation and superoxide production of eosinophils induced by human rGM-CSF and PAF, and that these mechanisms may be employed in vivo where eosinophils contact with stromal cells and/or proteins. Superoxides 124-134 integrin subunit alpha M Homo sapiens 28-33 7514638-12 1994 These results indicate that CD11b/CD18 (Mac-1)-dependent cellular adhesion plays an important role in the degranulation and superoxide production of eosinophils induced by human rGM-CSF and PAF, and that these mechanisms may be employed in vivo where eosinophils contact with stromal cells and/or proteins. Superoxides 124-134 integrin subunit alpha M Homo sapiens 40-45 7902790-2 1993 The O2- production, but not the cell adherence to FN, was completely inhibited by two MoAbs against CD18 and by a MoAb against CD11b, suggesting the involvement of CD11b-CD18 integrins in the neutrophil oxidative response. Superoxides 4-6 integrin subunit alpha M Homo sapiens 127-132 7902790-2 1993 The O2- production, but not the cell adherence to FN, was completely inhibited by two MoAbs against CD18 and by a MoAb against CD11b, suggesting the involvement of CD11b-CD18 integrins in the neutrophil oxidative response. Superoxides 4-6 integrin subunit alpha M Homo sapiens 164-169 8342134-4 1993 We therefore undertook this study with the hypothesis that PAF-induced PMN superoxide production requires CD11B-mediated PMN-endothelial cell adherence. Superoxides 75-85 integrin subunit alpha M Homo sapiens 106-111 8097228-8 1993 Nevertheless, increased CD11b expression was related to an increased capacity to generate superoxide after stimulation with opsonized zymosan. Superoxides 90-100 integrin subunit alpha M Homo sapiens 24-29 8004151-0 1993 Enhanced generation of O2- by human neutrophils via a complement iC3b/Mac-1 interaction. Superoxides 23-25 integrin subunit alpha M Homo sapiens 70-75 8004151-1 1993 There is evidence for a tumor necrosis factor alpha (TNF alpha)-initiated and CD11b/CD18-dependent burst of superoxide anion (O2-) and hydrogen peroxide production by human polymorphonuclear leukocytes which are adherent to surfaces bearing a variety of proteins. Superoxides 108-124 integrin subunit alpha M Homo sapiens 78-83 8004151-1 1993 There is evidence for a tumor necrosis factor alpha (TNF alpha)-initiated and CD11b/CD18-dependent burst of superoxide anion (O2-) and hydrogen peroxide production by human polymorphonuclear leukocytes which are adherent to surfaces bearing a variety of proteins. Superoxides 126-128 integrin subunit alpha M Homo sapiens 78-83 8004151-8 1993 Antibodies to CD18 (R15.7) or CD11b (CL44 and 60.1) reduced the incremental production of O2- by 76, 71 and 77%, respectively. Superoxides 90-92 integrin subunit alpha M Homo sapiens 30-35 2166208-2 1990 The aim of this investigation was to evaluate the role of CD11b/CD18 membrane glycoproteins on superoxide release from granulocytes. Superoxides 95-105 integrin subunit alpha M Homo sapiens 58-63 1676856-1 1991 Components involved in superoxide anion production (cytochrome b) and in cell adhesion processes (CD11b, CD11c, CD18), two early functional responses of neutrophils during acute inflammation, are intracellularly located in resting human neutrophils. Superoxides 23-39 integrin subunit alpha M Homo sapiens 98-103