PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31550857-0 2019 [PDCD4 enhances the inhibitory effect of As(2)O(3) on the growth and NF-kappaB signaling pathway in neuroblastoma cells]. Superoxides 41-50 nuclear factor kappa B subunit 1 Homo sapiens 69-78 33838472-0 2021 Sustained IKKbeta phosphorylation and NF-kappaB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56gamma3 and PP2A inactivation. Superoxides 62-72 nuclear factor kappa B subunit 1 Homo sapiens 38-47 33838472-3 2021 Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2-) mediates sustained IKK phosphorylation, and induces downstream degradation of IkappaBalpha, leading to the nuclear localization and transcriptional activation of NF-kappaB. Superoxides 91-101 nuclear factor kappa B subunit 1 Homo sapiens 270-279 31550857-17 2019 Conclusion: PDCD4 enhances the inhibitory effect of As(2)O(3) on the growth and NF-kappaB signaling pathway in neuroblastoma cells. Superoxides 52-61 nuclear factor kappa B subunit 1 Homo sapiens 80-89 31565647-6 2018 Moreover, RQ-PCR analysis revealed that the enhanced cytotoxic effect of As2O3 in the presence of melatonin is mediated, at least partly, through suppressing the expression of NF-kappaB anti-apoptotic target genes such as MCL-1, BCL-2, survivin, XIAP, and c-IAP1 in breast cancer cells. Superoxides 73-78 nuclear factor kappa B subunit 1 Homo sapiens 176-185 30508577-5 2019 In adults, this increased generation of reactive oxygen and nitrogen species (RONS) activate redox-sensitive transcription factors such as nuclear factor kappaB (NFkappaB), activator protein-1 (AP1) and heat shock factor 1 (HSF1), resulting in increases in cytoprotective proteins such as the superoxide dismutases, catalase and heat shock proteins that prevent oxidative damage to tissues and facilitate remodelling and proteostasis in both an intra- and inter-cellular manner. Superoxides 293-303 nuclear factor kappa B subunit 1 Homo sapiens 139-160 30508577-5 2019 In adults, this increased generation of reactive oxygen and nitrogen species (RONS) activate redox-sensitive transcription factors such as nuclear factor kappaB (NFkappaB), activator protein-1 (AP1) and heat shock factor 1 (HSF1), resulting in increases in cytoprotective proteins such as the superoxide dismutases, catalase and heat shock proteins that prevent oxidative damage to tissues and facilitate remodelling and proteostasis in both an intra- and inter-cellular manner. Superoxides 293-303 nuclear factor kappa B subunit 1 Homo sapiens 162-170 19113817-3 2009 Cellular stimulation by TNF-alpha induced NADPH-dependent superoxide production in the endosomal compartment, and this ROS was required for IKK-mediated activation of NF-kappaB. Superoxides 58-68 nuclear factor kappa B subunit 1 Homo sapiens 167-176 26528122-0 2015 Angiotensin II-superoxide-NFkappaB signaling and aortic baroreceptor dysfunction in chronic heart failure. Superoxides 15-25 nuclear factor kappa B subunit 1 Homo sapiens 26-34 24002659-8 2014 We interestingly found that superoxide anion and hydrogen peroxide induced a diverse apoptosis level by differently inhibiting GI via NF-kappaB pathway. Superoxides 28-44 nuclear factor kappa B subunit 1 Homo sapiens 134-143 22355351-8 2012 These newly discovered regulators conveyed their activity through a non-conventional RELB-depended NFkappaB signaling pathway and regulation of superoxide activity. Superoxides 144-154 nuclear factor kappa B subunit 1 Homo sapiens 99-107 26001727-2 2015 Nuclear factor-kappa B (NF-kappaB) activation by TNFalpha requires endosomal superoxide production by Nox1. Superoxides 77-87 nuclear factor kappa B subunit 1 Homo sapiens 0-22 26001727-2 2015 Nuclear factor-kappa B (NF-kappaB) activation by TNFalpha requires endosomal superoxide production by Nox1. Superoxides 77-87 nuclear factor kappa B subunit 1 Homo sapiens 24-33 23454417-2 2013 Peroxynitrite, formed from NO and superoxide, can induce multiple proteins nitration, even including NF-kappaB and iNOS, to alter their functions. Superoxides 34-44 nuclear factor kappa B subunit 1 Homo sapiens 101-110 18287332-9 2008 These results demonstrate that extracellular superoxide has proinflammatory effects on neutrophils, predominantly acting through an TLR4-dependent mechanism that enhances nuclear translocation of NF-kappaB and increases expression of NF-kappaB-dependent cytokines. Superoxides 45-55 nuclear factor kappa B subunit 1 Homo sapiens 196-205 18523147-2 2008 U937 cells with a stably transfected repressor of NF-kappaB (IkappaBalpha-S32A/S36A) demonstrated significantly lower superoxide release and lower CYBB and NCF1 gene expression compared with control U937 cells. Superoxides 118-128 nuclear factor kappa B subunit 1 Homo sapiens 50-59 18378695-1 2008 The compartmentalized production of superoxide (*O(2)(-)) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation. Superoxides 36-46 nuclear factor kappa B subunit 1 Homo sapiens 135-144 18287332-9 2008 These results demonstrate that extracellular superoxide has proinflammatory effects on neutrophils, predominantly acting through an TLR4-dependent mechanism that enhances nuclear translocation of NF-kappaB and increases expression of NF-kappaB-dependent cytokines. Superoxides 45-55 nuclear factor kappa B subunit 1 Homo sapiens 234-243 17704302-8 2007 In addition, we found that in parallel with the restoration of decreased S-nitrosylation of NF-kappaB, high glucose-induced NF-kappaB activation was blocked by the superoxide inhibitors. Superoxides 164-174 nuclear factor kappa B subunit 1 Homo sapiens 92-101 18287332-4 2008 Extracellular superoxide generation induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) and increased neutrophil production of the NF-kappaB-dependent cytokines tumor necrosis factor-alpha (TNF-alpha) and macrophage inhibitory protein-2 (MIP-2). Superoxides 14-24 nuclear factor kappa B subunit 1 Homo sapiens 69-90 18287332-4 2008 Extracellular superoxide generation induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) and increased neutrophil production of the NF-kappaB-dependent cytokines tumor necrosis factor-alpha (TNF-alpha) and macrophage inhibitory protein-2 (MIP-2). Superoxides 14-24 nuclear factor kappa B subunit 1 Homo sapiens 92-101 18287332-4 2008 Extracellular superoxide generation induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) and increased neutrophil production of the NF-kappaB-dependent cytokines tumor necrosis factor-alpha (TNF-alpha) and macrophage inhibitory protein-2 (MIP-2). Superoxides 14-24 nuclear factor kappa B subunit 1 Homo sapiens 146-155 18091741-7 2008 Nuclear translocation of NFkappaB (p65) was noted within 5 min of exposure to H(2)O(2) and at least 15 min after exposure to superoxide or BSO. Superoxides 125-135 nuclear factor kappa B subunit 1 Homo sapiens 25-33 17704302-8 2007 In addition, we found that in parallel with the restoration of decreased S-nitrosylation of NF-kappaB, high glucose-induced NF-kappaB activation was blocked by the superoxide inhibitors. Superoxides 164-174 nuclear factor kappa B subunit 1 Homo sapiens 124-133 14630727-10 2004 Treatment of cells with a superoxide anion scavenger (polyethylene glycol-superoxide dismutase) or IkappaB kinase inhibitor (prostaglandin A(1)) could prevent Hcy-induced activation of IKK kinases and NF-kappaB in endothelial cells. Superoxides 26-42 nuclear factor kappa B subunit 1 Homo sapiens 201-210 16919916-10 2006 These results demonstrate that increased intracellular superoxide concentrations are proinflammatory in neutrophils, acting through a p38 MAPK dependent mechanism that results in enhanced nuclear accumulation of NF-kappaB and increased expression of NF-kappaB dependent proinflammatory cytokines. Superoxides 55-65 nuclear factor kappa B subunit 1 Homo sapiens 212-221 16919916-10 2006 These results demonstrate that increased intracellular superoxide concentrations are proinflammatory in neutrophils, acting through a p38 MAPK dependent mechanism that results in enhanced nuclear accumulation of NF-kappaB and increased expression of NF-kappaB dependent proinflammatory cytokines. Superoxides 55-65 nuclear factor kappa B subunit 1 Homo sapiens 250-259 16598535-6 2006 Moreover, superoxide and hydrogen peroxide activate the redox-sensitive transcription factors NF-kappaB and thus mediates expression of proinflammatory proteins like adhesion molecules. Superoxides 10-20 nuclear factor kappa B subunit 1 Homo sapiens 94-103 15821443-4 2005 In THP-1 and cultured VSMC, O2- caused an increase in NF-kappa B activation (P < 0.05) that was correlated with inhibitory I kappa B-alpha degradation. Superoxides 28-30 nuclear factor kappa B subunit 1 Homo sapiens 54-64 16209336-5 2005 Angiotensin II induces superoxide and superoxide-derived hydrogen peroxide production, which may stimulate many proatherosclerotic processes, including increased expression of adhesion molecules, chemoattractants and activation of transcription factor NF-kappaB. Superoxides 23-33 nuclear factor kappa B subunit 1 Homo sapiens 252-261 16209336-5 2005 Angiotensin II induces superoxide and superoxide-derived hydrogen peroxide production, which may stimulate many proatherosclerotic processes, including increased expression of adhesion molecules, chemoattractants and activation of transcription factor NF-kappaB. Superoxides 38-48 nuclear factor kappa B subunit 1 Homo sapiens 252-261 15102862-7 2004 Our results demonstrate that NF-kappaB plays an essential role in activation of wild-type p53 tumor suppressor to initiate proapoptotic signaling in response to overgeneration of superoxide. Superoxides 179-189 nuclear factor kappa B subunit 1 Homo sapiens 29-38 17537988-7 2007 Pharmacological inhibitors of NF-kappaB activation blocked TNF-alpha-induced up-regulation of NCF1, NCF2, and CYBB message, which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production. Superoxides 224-227 nuclear factor kappa B subunit 1 Homo sapiens 30-39 17537988-8 2007 These data demonstrate that the increase in and/or maintenance of O2*- production in TNF-alpha-treated MonoMac1 cells and monocytes are a result, in part, of transcriptional up-regulation of three essential NADPH oxidase genes via the NF-kappaB pathway. Superoxides 66-69 nuclear factor kappa B subunit 1 Homo sapiens 235-244 16394009-9 2006 CpG-DNA evoked concomitant increases in intracellular superoxide and NO levels, leading to enhanced ONOO- formation and, consequently, nuclear accumulation of c-Fos and NF-kappaB. Superoxides 54-64 nuclear factor kappa B subunit 1 Homo sapiens 169-178 16279946-9 2005 This reaction involves the TNFalpha-induced generation of superoxide leading to activation of NF-kappaB, and can be abolished by antioxidants and by overexpression of a super-suppressor phosphorylation-resistant IkappaBalpha. Superoxides 58-68 nuclear factor kappa B subunit 1 Homo sapiens 94-103 15671037-3 2005 We previously showed that RelA-NF-kappaB functioned as a proapoptotic factor by activating the p53-signaling pathway in response to doxycycline-induced superoxide. Superoxides 152-162 nuclear factor kappa B subunit 1 Homo sapiens 31-40 15671037-4 2005 In the present study, we demonstrate that the ability of doxycycline/superoxide to induce expression of polo-like kinase 3 (Plk3) depends on NF-kappaB activity. Superoxides 69-79 nuclear factor kappa B subunit 1 Homo sapiens 141-150 14630727-11 2004 In conclusion, these results suggest that Hcy-induced superoxide anion production may play a potential role for NF-kappaB activation in the early stages of atherosclerosis in the vascular wall via activation of IkappaB kinases. Superoxides 54-70 nuclear factor kappa B subunit 1 Homo sapiens 112-121 12960242-7 2003 Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8. Superoxides 136-146 nuclear factor kappa B subunit 1 Homo sapiens 244-253 12807725-3 2003 The gas phase of CS contains free radicals such as superoxide radicals, hydroxyl radicals and hydrogen peroxide, which potentially can activate NF-kappaB. Superoxides 51-70 nuclear factor kappa B subunit 1 Homo sapiens 144-153 11557318-4 2001 In contrast, NF-kappaB in melanoma cells is strongly recruited by changes in redox status and exhibits a correlative relationship to intracellular hydrogen peroxide (but not superoxide anion). Superoxides 174-190 nuclear factor kappa B subunit 1 Homo sapiens 13-22 11557318-8 2001 The responsiveness of NF-kappaB and AP-1 recruitment to intracellular levels of hydrogen peroxide and superoxide anion without concomitant control of apoptosis provides a general mechanism by which these cells can escape noxious injury (e.g., chemotherapy). Superoxides 102-118 nuclear factor kappa B subunit 1 Homo sapiens 22-31 10900176-0 2000 NF- kappa B independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production. Superoxides 184-194 nuclear factor kappa B subunit 1 Homo sapiens 0-11 11824481-9 2001 Strain-induced luciferase activity was blunted by coincubation with RGD peptides or calphostin C. Thus, exposure of endothelial cells to cyclic strain led to integrin activation of a PKC-sensitive pathway that results in increased superoxide anion production and mobilization of NFkappaB. Superoxides 231-247 nuclear factor kappa B subunit 1 Homo sapiens 279-287 10873158-3 2000 Both nuclear translocation of NF-kappaB and enhanced kappaB-dependent transcription induced by V(IV) were inhibited by overexpression of catalase, but not Cu,Zn superoxide dismutase (Cu,Zn-SOD), indicating that peroxides rather than superoxides initiated signaling. Superoxides 233-244 nuclear factor kappa B subunit 1 Homo sapiens 30-39 10921280-6 2000 Acute exposure to cigarette smoke initiates a superoxide-dependent mechanism that, through NF-kappa B activation and IL-8 expression, induces infiltration of neutrophils into the airways in vivo. Superoxides 46-56 nuclear factor kappa B subunit 1 Homo sapiens 91-101 9733146-9 1998 These results suggest that, during sperm capacitation, Ca2+ induces an elevation in cAMP levels; this cAMP, through undefined serine/threonine protein phosphorylation, stimulates the generation of superoxide anion, which, in turn, causes the increase in p105/81 phosphotyrosine contents. Superoxides 197-213 nuclear factor kappa B subunit 1 Homo sapiens 254-258 10440583-0 1999 The role of superoxide radical in TNF-alpha induced NF-kappaB activation. Superoxides 12-30 nuclear factor kappa B subunit 1 Homo sapiens 52-61 10728373-0 2000 Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-kappa B in human endothelial cells. Superoxides 35-51 nuclear factor kappa B subunit 1 Homo sapiens 74-96 10728373-8 2000 RESULTS: The treatment of the cells with superoxide anion for 60 min increased the NF-kappa B/DNA binding activity. Superoxides 41-57 nuclear factor kappa B subunit 1 Homo sapiens 83-93 10728373-11 2000 Pretreatment of the cells with calphostin C (100-400 nmol/l) and chelerythrine chloride (5-10 mumol/l), inhibitors of PKC, abolished the superoxide anion-induced NF-kappa B activation. Superoxides 137-153 nuclear factor kappa B subunit 1 Homo sapiens 162-172 10728373-12 2000 Down-regulation of endogenous PKC by long-term exposure to phorbol 12-myristate 13-acetate decreased the superoxide anion-induced NF-kappa B activation to a basal level. Superoxides 105-121 nuclear factor kappa B subunit 1 Homo sapiens 130-140 10728373-14 2000 CONCLUSION: These results suggest that PKC is involved in the activation of NF-kappa B by superoxide anion in human endothelial cells. Superoxides 90-106 nuclear factor kappa B subunit 1 Homo sapiens 76-86 10453032-0 1999 Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression. Superoxides 0-10 nuclear factor kappa B subunit 1 Homo sapiens 46-56 10453032-5 1999 Preactivation with superoxide promoted cyclooxygenase-2 induction that was NF-kappa B and AP-1 mediated. Superoxides 19-29 nuclear factor kappa B subunit 1 Homo sapiens 75-85 11228746-3 1999 TNF-induced NF-kappa B activation was inhibited by both superoxide and lipid peroxide quenchers but potentiated by an hydroxyl radical quencher. Superoxides 56-66 nuclear factor kappa B subunit 1 Homo sapiens 12-22 11228746-5 1999 TNF-induced JNK activation, similar to NF-kappa B, was inhibited by both superoxide and lipid peroxide quenchers but potentiated by hydroxyl radical quencher. Superoxides 73-83 nuclear factor kappa B subunit 1 Homo sapiens 39-49 11228746-8 1999 Overall, these results suggest that hydroxyl radicals mediate TNF-induced apoptosis but not activation of NF-kappa B, AP-1, and JNK; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis; and lipid peroxides are required for all the signals induced by TNF. Superoxides 133-143 nuclear factor kappa B subunit 1 Homo sapiens 161-171 9337212-0 1997 Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Superoxides 42-58 nuclear factor kappa B subunit 1 Homo sapiens 115-124 9337212-11 1997 This PDGF-induced O2.- production may be involved in vascular lesion formation by mediating, at least in part, NF-kappaB activation and MCP-1 induction. Superoxides 18-20 nuclear factor kappa B subunit 1 Homo sapiens 111-120 8924517-4 1996 The altered ratio of NO/superoxide anion (O2-) production has been proposed to alleviate intrinsic inhibition of the transcription factor NF kappa B and lead to enhanced expression of adhesion molecules and chemotactic factors at the endothelial surface. Superoxides 24-40 nuclear factor kappa B subunit 1 Homo sapiens 138-148 8950027-0 1996 Bovine papillomavirus oncoprotein E5 induces the NF kappa B activation through superoxide radicals. Superoxides 79-89 nuclear factor kappa B subunit 1 Homo sapiens 49-59 8950027-8 1996 We conclude that the superoxide anion is involved in activation of NF kappa B. Superoxides 21-37 nuclear factor kappa B subunit 1 Homo sapiens 67-77 9013127-4 1997 Superoxide dismutase and catalase abolish both sperm capacitation and tyrosine phosphorylation of p105 and p81, suggesting the involvement of O2.- and hydrogen peroxide in these two processes. Superoxides 142-144 nuclear factor kappa B subunit 1 Homo sapiens 98-102 1404592-2 1992 An involvement of oxygen radicals was more directly evident from the induction of NF-kappa B by low concentrations of H2O2 and the demonstration that cells stimulated with various NF-kappa B inducers release H2O2 and superoxide. Superoxides 217-227 nuclear factor kappa B subunit 1 Homo sapiens 180-190 9383399-0 1995 The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Superoxides 35-45 nuclear factor kappa B subunit 1 Homo sapiens 102-112 9383399-6 1995 In contrast, stable overexpression of cytoplasmic Cu/Zn-dependent superoxide dismutase (SOD), which enhances the production of H2O2 from superoxide, potentiated NF-kappa B activation. Superoxides 66-76 nuclear factor kappa B subunit 1 Homo sapiens 161-171