PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	56-60	
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	145-149	
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	145-149	
30889865-5	2019	We propose a novel hypothesis that ER-alpha36-GPER signaling initially induces rapid and temporal activation of NADPH oxidase 1 to generate superoxide, which subsequently activates redox-sensitive neutral sphingomyelinase 2 generating the lipid signaling mediator ceramide.	Superoxides	140-150	G protein-coupled estrogen receptor 1	Homo sapiens	46-50