PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33541361-9	2021	RESULTS: Overexpression of SIRT3 in the CA1 region attenuated anesthesia/surgery-induced learning and memory dysfunction as well as synaptic plasticity dysfunction and the oxidative stress response (superoxide dismutase [SOD] and malondialdehyde [MDA]) in aged mice with POCD.	Superoxides	199-209	sirtuin 3	Mus musculus	27-32	
34249270-4	2021	Results: SIRT3 KO caused increased expression of Scr, pKIM-1, and inducible nitric oxide synthase protein in the kidneys of septic mice, and decreased the levels of superoxide dismutase, catalase, and mitochondrial complex enzymes I/II/III/IV.	Superoxides	165-175	sirtuin 3	Mus musculus	9-14	
35453391-4	2022	We found that the selective deletion of SIRT3 in endothelial cells further impaired endothelium-dependent vasodilatation in the aorta treated with IL-1beta, which was accompanied by upregulation of vascular inflammation markers and mitochondrial superoxide overproduction.	Superoxides	246-256	sirtuin 3	Mus musculus	40-45	
31876685-11	2020	These observations suggest that SirT3-SOD2-intracellular superoxide is a key component associated with the cognitive dysfunction induced by LTIH.	Superoxides	57-67	sirtuin 3	Mus musculus	32-37	
32119761-5	2020	SIRT3 deficiency delayed healing rate, reduced blood supply and vascular endothelial growth factor expression, promoted superoxide production, increased malondialdehyde (MDA) levels, decreased total antioxidant capacity (T-AOC), reduced superoxide dismutase (SOD) activity and aggravated ultrastructure disorder in skin wound of diabetic mice.	Superoxides	120-130	sirtuin 3	Mus musculus	0-5	
32119761-7	2020	SIRT3 deficiency also suppressed alpha-smooth muscle actin (alpha-SMA) expression, enhanced superoxide production but decreased mitochondrial membrane potential with HG stimulation after scratch.	Superoxides	92-102	sirtuin 3	Mus musculus	0-5	
23919724-7	2014	This work provides strong evidence for the causal role of O2( -) in the liver injury process initiated by whole-body irradiation in SIRT3(-/-) mice.	Superoxides	58-60	sirtuin 3	Mus musculus	132-137	
27071400-11	2016	Abrogation of this feedback regulation by simultaneous knockdown of C/EBP-beta and Sirt3 exacerbated mitochondrial superoxide accumulation and culminated into endothelial cell death upon prolonged culture.	Superoxides	115-125	sirtuin 3	Mus musculus	83-88	
23919724-8	2014	CONCLUSION: These results support the hypothesis that O2( -) mediates acute liver injury in SIRT3(-/-) animals exposed to whole-body gamma-radiation and suggest that GC4401 could be used as a radio-protective compound in vivo.	Superoxides	54-56	sirtuin 3	Mus musculus	92-97	
21172655-1	2010	Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor-permissive environment, and mammary tumor development.	Superoxides	103-113	sirtuin 3	Mus musculus	61-66	
23819597-5	2013	To determine the contribution of mitochondrial oxidative metabolism, Lck-Bax38&1 over expressing mice were crossed with knockouts of the mitochondrial protein deacetylase, Sirtuin 3 (Sirt3), which regulates superoxide metabolism.	Superoxides	211-221	sirtuin 3	Mus musculus	176-185	
23819597-5	2013	To determine the contribution of mitochondrial oxidative metabolism, Lck-Bax38&1 over expressing mice were crossed with knockouts of the mitochondrial protein deacetylase, Sirtuin 3 (Sirt3), which regulates superoxide metabolism.	Superoxides	211-221	sirtuin 3	Mus musculus	187-192	
23819597-6	2013	Sirt3(-/-)/Lck-Bax38&1 mice demonstrated significant increases in thymocyte superoxide levels and acceleration of lymphomagenesis (P < 0.001).	Superoxides	80-90	sirtuin 3	Mus musculus	0-5	
21172655-6	2010	Furthermore, infection of Sirt3-/- MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide.	Superoxides	192-202	sirtuin 3	Mus musculus	26-31	
20129246-2	2010	This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic instability.	Superoxides	155-165	sirtuin 3	Mus musculus	28-33