PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31643023-12	2020	Mechanically, Dex blocked Dox-induced the ubiquitination of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha), leading to the restoration of PGC-1alpha and downstream oxidative stress-protective molecules uncoupling protein 2 and manganese-dependent superoxide dismutase expression.	Superoxides	282-292	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	60-128	
32745765-11	2020	Notably, SIRT3 RNAi suppressed OXPHOS activity, while PGC-1alpha RNAi triggered mitochondrial superoxide and intracellular H2O2 production in hypoxia combined with curcumin-treated BMSCs.	Superoxides	94-104	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	54-64	
34356358-0	2021	Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway.	Superoxides	41-51	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	203-213	
31643023-12	2020	Mechanically, Dex blocked Dox-induced the ubiquitination of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha), leading to the restoration of PGC-1alpha and downstream oxidative stress-protective molecules uncoupling protein 2 and manganese-dependent superoxide dismutase expression.	Superoxides	282-292	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	130-140	
25047750-10	2014	Last, menadione-induced superoxide generation was inhibited by AMPK pharmacologic activators and by overexpression of PGC-1alpha or FoxO3A.	Superoxides	24-34	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	118-128	
26182379-7	2015	Furthermore, PGC-1alpha overexpression inhibited the decrease in nitric oxide (NO) generation and the increase in superoxide anion (O2 (-)) production in DOCA-salt-treated mice, in parallel with improved endothelium-dependent relaxation.	Superoxides	114-130	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-23	
26182379-7	2015	Furthermore, PGC-1alpha overexpression inhibited the decrease in nitric oxide (NO) generation and the increase in superoxide anion (O2 (-)) production in DOCA-salt-treated mice, in parallel with improved endothelium-dependent relaxation.	Superoxides	132-134	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-23	
31614775-3	2019	Media conditioned by peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha)-expressing myotubes, reproducing some metabolic adaptations of aerobic exercise, as increased mitochondrial biogenesis and oxidative phosphorylation, restrained constitutively active Forkhead box-containing subfamily O3 (caFoxO3)-induced proteolysis.	Superoxides	318-320	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	21-88	
31614775-3	2019	Media conditioned by peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha)-expressing myotubes, reproducing some metabolic adaptations of aerobic exercise, as increased mitochondrial biogenesis and oxidative phosphorylation, restrained constitutively active Forkhead box-containing subfamily O3 (caFoxO3)-induced proteolysis.	Superoxides	318-320	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	90-99	
31614775-3	2019	Media conditioned by peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha)-expressing myotubes, reproducing some metabolic adaptations of aerobic exercise, as increased mitochondrial biogenesis and oxidative phosphorylation, restrained constitutively active Forkhead box-containing subfamily O3 (caFoxO3)-induced proteolysis.	Superoxides	327-329	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	21-88	
31614775-3	2019	Media conditioned by peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha)-expressing myotubes, reproducing some metabolic adaptations of aerobic exercise, as increased mitochondrial biogenesis and oxidative phosphorylation, restrained constitutively active Forkhead box-containing subfamily O3 (caFoxO3)-induced proteolysis.	Superoxides	327-329	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	90-99	
28869535-10	2017	Scavenging of mitochondrial superoxide attenuated mitochondrial DNA damage and preserved the mitochondrial respiration, in addition to suppression of the expression of p53 and preservation of the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) in ischemic skeletal muscles with aging.	Superoxides	28-38	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	210-277	
28869535-10	2017	Scavenging of mitochondrial superoxide attenuated mitochondrial DNA damage and preserved the mitochondrial respiration, in addition to suppression of the expression of p53 and preservation of the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) in ischemic skeletal muscles with aging.	Superoxides	28-38	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	279-289	
23788763-5	2013	By using the mitochondrial-specific superoxide dye MitoSox and complex I inhibitor rotenone, we identified the mitochondrial respiratory chain as the major PGC-1alpha-dependent reactive oxygen species source in vivo, accompanied by increased vascular inflammation and cell senescence.	Superoxides	36-46	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	156-166	
21964033-0	2011	Impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain.	Superoxides	49-59	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	10-20	
21964033-4	2011	However, the impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain is not known.	Superoxides	62-72	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	23-33