PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20518848-8	2011	Furthermore, inhibition of PI3K and Rac1 activity decreased LPS-induced superoxide generation which was associated with a significant reduction in ERK1/2 phosphorylation.	Superoxides	72-82	mitogen-activated protein kinase 3	Mus musculus	147-153	
24159377-8	2013	This superoxide increase was inhibited by the gp91 ds-tat and ERK 1/2 inhibitor (PD98059).	Superoxides	5-15	mitogen-activated protein kinase 3	Mus musculus	62-69	
24159377-9	2013	In conclusion, adenosine-induced increase in CF in isolated heart involves Nox2-generated superoxide, possibly through ERK 1/2 phosphorylation with subsequent p47-phox subunit phosphorylation.	Superoxides	90-100	mitogen-activated protein kinase 3	Mus musculus	119-126	
27329107-9	2016	Exploring the underlying mechanisms showed that alpha-Syn (29-40) peptide triggered Nox2 to generate extracellular superoxide and its metabolite H2O2 by binding to the catalytic unit gp91 (phox) of Nox2; diffusing into cytosol, H2O2 activated Erk1/2 kinase to phosphorylate p47 (phox) and p67 (phox) and further activated Nox2, establishing a positive feedback loop to amplify the Nox2-mediated response.	Superoxides	115-125	mitogen-activated protein kinase 3	Mus musculus	243-249	
20420821-0	2010	Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells.	Superoxides	39-49	mitogen-activated protein kinase 3	Mus musculus	20-26	
20420821-5	2010	The plumbagin-stimulated ERK1/2 and Akt activities were sensitive to an antioxidant NAC, superoxide dismutase mimetic MnTBAP, superoxide scavenger Tiron and NAD(P)H oxidase inhibitor DPI.	Superoxides	89-99	mitogen-activated protein kinase 3	Mus musculus	25-31