PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14556853-4 2003 We also show that menadione, a superoxide anion generator and a highly reactive electrophile, operates both modes of Yap1 activation. Superoxides 31-47 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 117-121 14556853-6 2003 We propose that Yap1 has two distinct molecular redox centers, one triggered by ROS (hydroperoxides and the superoxide anion) and the other by chemicals with thiol reactivity (electrophiles and divalent heavy metals cations). Superoxides 108-124 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 16-20