PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25476852-5 2015 We found that incubation of purified recombinant Sirt6 protein with 3-morpholinosydnonimine (SIN-1; a peroxynitrite donor that generates nitric oxide and superoxide simultaneously) increased Sirt6 tyrosine nitration and decreased its intrinsic catalytic activity. Superoxides 154-164 MAPK associated protein 1 Homo sapiens 93-98 24405159-9 2014 Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2-) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Superoxides 107-123 MAPK associated protein 1 Homo sapiens 135-140 24405159-9 2014 Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2-) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Superoxides 125-128 MAPK associated protein 1 Homo sapiens 135-140 24375019-2 2014 SIN-1(3-morpholino-sydnonimine), which can lead the simultaneous generation of superoxide anion and nitric oxide, and then form the highly reactive species ONOO(-), induced dose-dependent inhibition in amplitudes of both mEPSCs and sEPSCs. Superoxides 79-95 MAPK associated protein 1 Homo sapiens 0-5 15281495-3 2004 Thus, we hypothesized that exposure of plasma to the OONO- generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide, would result in a decrease in hemostatic function via diminished coagulation protein activity. Superoxides 154-164 MAPK associated protein 1 Homo sapiens 99-104 21981804-5 2011 On the other hand, an O(2)(-) donor, 3-(4-Morpholinyl)sydnonimine (SIN-1), induced TNFalpha in microglia, and the effects of SIN-1 were completely abolished in the presence of superoxide dismutase. Superoxides 22-29 MAPK associated protein 1 Homo sapiens 67-72 21981804-5 2011 On the other hand, an O(2)(-) donor, 3-(4-Morpholinyl)sydnonimine (SIN-1), induced TNFalpha in microglia, and the effects of SIN-1 were completely abolished in the presence of superoxide dismutase. Superoxides 22-29 MAPK associated protein 1 Homo sapiens 125-130 16843826-8 2006 Neuronal NOS half-saturated with BH4 and the donor compound 3-morpholinosydnonimine (SIN-1) were used as enzymatic and nonenzymatic sources of NO/superoxide, respectively. Superoxides 146-156 MAPK associated protein 1 Homo sapiens 85-90 15302679-6 2004 Superoxide dismutase (150 U ml(-1)) plus catalase (1200 U ml(-1)), used to remove superoxide and hence prevent peroxynitrite formation, prevented the inhibitory effect of SIN-1 (which generates superoxide) but not of MAHMA/NO or FK409. Superoxides 82-92 MAPK associated protein 1 Homo sapiens 171-176 15302679-6 2004 Superoxide dismutase (150 U ml(-1)) plus catalase (1200 U ml(-1)), used to remove superoxide and hence prevent peroxynitrite formation, prevented the inhibitory effect of SIN-1 (which generates superoxide) but not of MAHMA/NO or FK409. Superoxides 194-204 MAPK associated protein 1 Homo sapiens 171-176 21497204-8 2011 SIN-1 decomposition products, NO and superoxide anion or peroxynitrite, induced greater cytotoxicity in lymphocyte cultures (separately and in whole blood) supplemented with HEPES - the organic buffer that is widely used to maintain stable physiological pH in cell cultures -, due to H(2)O(2) production, than in cultures without HEPES. Superoxides 37-53 MAPK associated protein 1 Homo sapiens 0-5 21030671-6 2011 Sin-1 exposure caused a disproportionately large decrease in Ca(2+) sensitivity, evidently due to coproduction of superoxide, as it was prevented by Tempol, a superoxide dismutase mimetic. Superoxides 114-124 MAPK associated protein 1 Homo sapiens 0-5 19895807-0 2010 The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. Superoxides 12-28 MAPK associated protein 1 Homo sapiens 57-62 19895807-4 2010 3-morpholinosydnonimine (SIN-1) co-generates NO and O(2)(-), yielding ONOO(-). Superoxides 52-56 MAPK associated protein 1 Homo sapiens 25-30 20099714-5 2009 Cells were treated with Ang II, 3-morpholinosydnonimine (SIN-1), which liberates NO and superoxide anion generating peroxynitrite, or the lipopetide Toll-like receptor-2 (TLR-2) agonist Pam3CSK4. Superoxides 88-104 MAPK associated protein 1 Homo sapiens 57-62 18616952-8 2008 Conversely, a peroxynitrite donor (SIN-1) increased both neutrophil-PMVEC adhesion (38+/-2% vs. 14+/-1% control, p<0.01) and trans-PMVEC neutrophil migration; with both effects were completely inhibited by scavenging of NO, superoxide, or peroxynitrite (p<0.05 for each). Superoxides 227-237 MAPK associated protein 1 Homo sapiens 35-40 17977674-4 2007 SIN-1(3-morpholino-sydnonimine), which leads to the simultaneous generation of superoxide anion and NO, and then forms the highly reactive species ONOO(-), induced a dose-dependent inhibition in amplitudes of transient potassium currents (I(A)) and delayed rectifier potassium currents (I(K)). Superoxides 79-95 MAPK associated protein 1 Homo sapiens 0-5 17206381-3 2007 Upon exposure to 1 mM 3-morpholinosydnomine N-ethylcarbamide (SIN-1), a generator of peroxynitrite through the reaction between nitric oxide and superoxide anion, to U937 cells, the viability was lower and the protein oxidation, lipid peroxidation and oxidative DNA damage reflected by an increase in 8-hydroxy-2"-deoxyguanosine, were higher in the inhibitor-treated cells as compared to the control cells. Superoxides 145-161 MAPK associated protein 1 Homo sapiens 62-67 15289284-14 2004 GEA 3162 and SIN-1 oxidised the O(2)(-)- and ONOO(-)-sensitive dye, dihydrorhodamine 123 (DHR 123; 1 microm), suggesting that ONOO(-) released from these compounds is responsible for oxidation of DHR 123. Superoxides 32-39 MAPK associated protein 1 Homo sapiens 13-18 15326075-6 2004 SIN-1, NCX 4016, and NCX 4050 but not ASA alone inhibited the formation of O2*- and expression of gp91(phox). Superoxides 75-78 MAPK associated protein 1 Homo sapiens 0-5 15202767-1 2004 Dopamine (50 or 100 microM) attenuated the nuclear damage and cell death due to 500 microM SIN-1, a donor of superoxide and nitric oxide, in differentiated PC12 cells whereas 200 microM dopamine did not depress cell death. Superoxides 109-119 MAPK associated protein 1 Homo sapiens 91-96 15105207-4 2004 OONO(-) was generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide. Superoxides 107-117 MAPK associated protein 1 Homo sapiens 52-57 14502568-6 2003 The simultaneous donor of O(2) (-) and NO, SIN-1 (500 microM), also stimulated basal I(Ca) (22.8 +/- 2.1%, n = 13). Superoxides 26-30 MAPK associated protein 1 Homo sapiens 43-48 15129734-3 2004 The results indicate that the L-012-derived chemiluminescence induced by superoxide from hypoxanthine/xanthine oxidase (HX/XO) or by 3-morpholino sydnonimine (SIN-1)-derived peroxynitrite largely depends on the incubation time. Superoxides 73-83 MAPK associated protein 1 Homo sapiens 159-164 15901411-10 2004 It is suggested that light emission induced by the SIN1 cocktail results from the oxidation of SEL [IV] to the [VI] state, possibly due to the generation of mixtures of superoxide, peroxide, peroxynitrite and also of unidentified oxidant species, catalyzed by CoCo(2+). Superoxides 169-179 MAPK associated protein 1 Homo sapiens 51-55 14657004-5 2004 SIN-1, which releases both NO and superoxide (O2*-), reduced HIF-1alpha levels, suggesting that inhibitory NO donors may elicit effects through peroxynitrite (ONOO*-). Superoxides 34-44 MAPK associated protein 1 Homo sapiens 0-5 14657004-5 2004 SIN-1, which releases both NO and superoxide (O2*-), reduced HIF-1alpha levels, suggesting that inhibitory NO donors may elicit effects through peroxynitrite (ONOO*-). Superoxides 46-48 MAPK associated protein 1 Homo sapiens 0-5 11369646-5 2001 The results indicate that 3-(4-morpholinyl)-sydnonimine (SIN-1, an O2*- and NO* donor) and chemically synthesized peroxynitrite, but not S-nitroso-N-acetyl-D,L-penicillamine (SNAP, an NO* donor), have a strong apoptotic effect on human thymocytes (annexin V staining and TUNEL reaction). Superoxides 67-70 MAPK associated protein 1 Homo sapiens 57-62 14565769-7 2003 SIN-1-induced formation of AUXN is considered to be a superoxide-mediated reaction, while the structure of EPOX points to a two electron oxidation reaction involving a Michael type addition with peroxynitrite as the nucleophile, followed by cyclization yielding a (1,2)-dioxepin-5-one ring structure. Superoxides 54-64 MAPK associated protein 1 Homo sapiens 0-5 11677273-1 2001 3-Morpholinosyndnomine (SIN-1) has been reported to be a peroxynitrite (OONO(-)) donor because it produces both nitric oxide (NO) and superoxide (O(2)(-).) Superoxides 134-144 MAPK associated protein 1 Homo sapiens 24-29 11677273-1 2001 3-Morpholinosyndnomine (SIN-1) has been reported to be a peroxynitrite (OONO(-)) donor because it produces both nitric oxide (NO) and superoxide (O(2)(-).) Superoxides 146-150 MAPK associated protein 1 Homo sapiens 24-29 11417851-3 2001 Cells were pretreated with Danchunhwan and exposed to sodium nitroprusside (SNP), an NO donor, and 3-morpholinosydnonimine (SIN-1) which simultaneously generates NO and superoxide, thus possibly forming peroxynitrite. Superoxides 169-179 MAPK associated protein 1 Homo sapiens 124-129 10930123-4 2000 The cytotoxic effect of 3-morpholinosydnonimine (SIN-1), which is thought to form peroxynitrite (ONOO-) as a simultaneous O2- and NO generator, was completely blocked by SOD/CAT or Hb. Superoxides 122-124 MAPK associated protein 1 Homo sapiens 49-54 11170241-2 2001 Previously, we showed that S-nitroso-N-acetylpenicillamine-amine (SNAP), which generates nitric oxide, and 3-morpholinosydnonimine (Sin-1), which generates equal molar concentrations of superoxide and nitric oxide resulting in peroxynitrite production, exhibited different levels of cytotoxicity to normal human hepatocytes in culture. Superoxides 186-196 MAPK associated protein 1 Homo sapiens 132-137 11962084-3 2001 Such effect of SIN-1 realized mainly by nitric oxide effect and, partially, superoxide radical. Superoxides 76-94 MAPK associated protein 1 Homo sapiens 15-20 10545203-6 1999 Tyrosine Y(115) was the residue modified by nitration after exposure of ribonuclease A to different nitrating agents: chemically synthesized peroxynitrite, nitric oxide, and superoxide generated by SIN-1 or myeloperoxidase (MPO)/H(2)O(2) plus nitrite (NO(-2)) in the presence of bicarbonate/CO(2). Superoxides 174-184 MAPK associated protein 1 Homo sapiens 198-203 10581309-5 1999 SIN-1, unlike SNAP, can release both NO and superoxide anion, the precursors of peroxynitrite (OONO-). Superoxides 44-60 MAPK associated protein 1 Homo sapiens 0-5 10581309-12 1999 LY 83583, a superoxide anion generator, elicited a positive inotropic effect, like SIN-1. Superoxides 12-28 MAPK associated protein 1 Homo sapiens 83-88 10823274-1 2000 The 3-morpholinosydnonimine (SIN-1) generates both nitric oxide (NO) and superoxide anion (O2-). Superoxides 73-89 MAPK associated protein 1 Homo sapiens 29-34 10823274-1 2000 The 3-morpholinosydnonimine (SIN-1) generates both nitric oxide (NO) and superoxide anion (O2-). Superoxides 91-94 MAPK associated protein 1 Homo sapiens 29-34 10823274-6 2000 In vitro studies were used as an approach to investigate how simultaneous productions of NO and O2- from SIN-1 modify thrombin- or thapsigargin-induced platelet Ca2+ mobilization. Superoxides 96-98 MAPK associated protein 1 Homo sapiens 105-110 10823274-8 2000 This suggests that the effects of SIN-1 on platelet Ca2+ handling resemble those of NO, but are modulated by simultaneous O2- release, independently of H2O2 formation. Superoxides 122-124 MAPK associated protein 1 Homo sapiens 34-39 10660121-6 2000 Although SIN-1 generates both NO and superoxide radical thereby forming peroxynitrite (ONOO-), this donor had no appreciable effect on cellular ATP levels, even in the presence of superoxide dismutase. Superoxides 37-55 MAPK associated protein 1 Homo sapiens 9-14 10816077-5 2000 Moreover, knowing that GSH plays a crucial role in the regulation of nitric oxide-dependent apoptosis, U937-R and parental lines have been treated with SIN-1, which is known to generate significant amounts of O2 and nitric oxide. Superoxides 209-211 MAPK associated protein 1 Homo sapiens 152-157 10381591-18 1999 In addition, SIN-1 and LY 83583 exert cyclic GMP-independent positive inotropic effects, which require the generation of superoxide anion. Superoxides 121-137 MAPK associated protein 1 Homo sapiens 13-18 10627995-2 1999 LDL-oxidation by peroxynitrite or the simultaneous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Superoxides 83-93 MAPK associated protein 1 Homo sapiens 131-136 10493821-4 1999 The effect of SIN-1 in smooth muscle cells was abrogated by superoxide and peroxynitrite inhibitors, which supports the hypothesis that peroxynitrite is an activating species of PGHS-1. Superoxides 60-70 MAPK associated protein 1 Homo sapiens 14-19 10491133-9 1999 Only SIN-1, which produces peroxynitrite by generating both NO and superoxide anion, decreased the Soret region absorption and the pyridine hemochromogen spectrum of HO-2; superoxide dismutase (SOD) blocked the decrease. Superoxides 67-83 MAPK associated protein 1 Homo sapiens 5-10 10496147-4 1999 Sections were treated with 3-morpholinosydomine (SIN-1), which releases O2(-*) and NO simultaneously, with or without pre-treatment either with hemoglobin (3 microM) or melatonin (0.1-10 microM). Superoxides 72-74 MAPK associated protein 1 Homo sapiens 49-54 10229110-5 1999 Superoxide dismutase inhibited the effect of SIN-1, which indicates a role for superoxide, and contradicts a role for its dismutation product, hydrogen peroxide. Superoxides 79-89 MAPK associated protein 1 Homo sapiens 45-50 10489120-6 1999 SIN-1, on the other hand, generates NO and the superoxide anion which, in turn, generated peroxynitrite which was then converted to the hydroxyl radical. Superoxides 47-63 MAPK associated protein 1 Homo sapiens 0-5 10229110-9 1999 On the other hand, the simultaneous production of superoxide, as achieved with the NO-donor SIN-1, negated the inhibitory effect of NO. Superoxides 50-60 MAPK associated protein 1 Homo sapiens 92-97 9882464-1 1999 SIN-1 has been used, in vitro, to simultaneously generate nitric oxide (*NO) and superoxide (O*-2). Superoxides 81-91 MAPK associated protein 1 Homo sapiens 0-5 9808374-7 1998 3-morpholinosydomine (SIN-1), which releases O2- and NO simultaneously produced a significant dose-dependent relaxation of vascular tension, which pretreatment with hemoglobin did not affect SIN-1-induced relaxation. Superoxides 45-47 MAPK associated protein 1 Homo sapiens 22-27 10398565-11 1999 SIN-1 could be useful as a source of oxidant for the characterization of antioxidant behaviour in a system where superoxide and nitric oxide are simultaneously generated. Superoxides 113-123 MAPK associated protein 1 Homo sapiens 0-5 21781879-2 1998 3-Morpholinosydnonimine hydrochloride (SIN-1) produces NO and superoxide anion (O(2)( -)) which results in the formation of peroxynitrite (ONOO(-)). Superoxides 62-78 MAPK associated protein 1 Homo sapiens 39-44 21781879-2 1998 3-Morpholinosydnonimine hydrochloride (SIN-1) produces NO and superoxide anion (O(2)( -)) which results in the formation of peroxynitrite (ONOO(-)). Superoxides 80-84 MAPK associated protein 1 Homo sapiens 39-44 9582295-3 1998 In such studies 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a compound that simultaneously releases nitric oxide (.NO) and superoxide (O-2), is often used as a source for peroxynitrite. Superoxides 129-139 MAPK associated protein 1 Homo sapiens 58-63 9280288-5 1997 On the other hand, nitric oxide and superoxide generated concomitantly from 3-morpholinosydnonimine (SIN-1) did not induce appreciable hemolysis, while it converted hemoglobin to methemoglobin extensively. Superoxides 36-46 MAPK associated protein 1 Homo sapiens 101-106 9556559-1 1998 We report that exposure of aconitase to moderate concentrations of peroxynitrite, 3-morpholinosydnonimine (SIN-1; a superoxide- and nitric oxide-liberating substance), or hydrogen peroxide, inhibits the enzyme and enhances susceptibility to proteolytic digestion by the isolated 20 S proteasome. Superoxides 116-126 MAPK associated protein 1 Homo sapiens 107-112 9556559-3 1998 It should be noted that the superoxide and nitric oxide liberated by SIN-1 decomposition react to form a steady flux of peroxynitrite. Superoxides 28-38 MAPK associated protein 1 Homo sapiens 69-74 9452441-7 1998 The NO/O-2 donor SIN-1 caused only a slight accumulation of cGMP in the absence of GSH but was almost as effective as DEA/NO in the presence of the thiol. Superoxides 7-10 MAPK associated protein 1 Homo sapiens 17-22 9017230-4 1996 The sydnonimine SIN-1, which spontaneously decomposes to yield nitric oxide (NO) and superoxide anion radicals, led to axonal degeneration at concentrations between 1 microM and 10 microM. Superoxides 85-110 MAPK associated protein 1 Homo sapiens 16-21 9145927-4 1997 SIN-1 releases both nitric oxide and superoxide, which together form peroxynitrite. Superoxides 37-47 MAPK associated protein 1 Homo sapiens 0-5 9202724-3 1997 In the present study, we have compared SIN-1, which generates nitric oxide, superoxide anion and hydrogen peroxide, with two other nitric oxide donors, S-nitrosoglutathione (GSNO) and the tetra-iron-sulphur cluster nitrosyl, Roussin"s black salt (RBS). Superoxides 76-92 MAPK associated protein 1 Homo sapiens 39-44 9202724-11 1997 The nitric oxide and superoxide anion produced by SIN-1 are though to combine to form highly reactive peroxynitrite. Superoxides 21-37 MAPK associated protein 1 Homo sapiens 50-55 9144574-2 1997 Both Sin-1 which yields nitric oxide and peroxynitrite following the generation of superoxide anion plus nitric oxide, and SNAP which generates nitric oxide, induced dose dependent decreases in the colony forming capabilities of the human hepatocytes. Superoxides 83-99 MAPK associated protein 1 Homo sapiens 5-10 9144574-8 1997 The enhanced levels of Sin-1 cytotoxicity on the hepatocytes is suggested to be due both to the chemical generation of peroxynitrite and superoxide anion by Sin-1. Superoxides 137-153 MAPK associated protein 1 Homo sapiens 23-28 9144574-8 1997 The enhanced levels of Sin-1 cytotoxicity on the hepatocytes is suggested to be due both to the chemical generation of peroxynitrite and superoxide anion by Sin-1. Superoxides 137-153 MAPK associated protein 1 Homo sapiens 157-162 9048779-6 1997 SIN-1 has been reported to release both NO and superoxide and thereby to rapidly form peroxynitrite (ONOO-). Superoxides 47-57 MAPK associated protein 1 Homo sapiens 0-5 8224196-2 1993 Damage was induced following treatment with the nitric oxide donor SIN-1, which also releases superoxide, but was not reduced by exogenous superoxide dismutase, suggesting that nitric oxide itself, rather than superoxide or peroxynitrite may be the active species. Superoxides 94-104 MAPK associated protein 1 Homo sapiens 67-72 7943250-3 1994 The simultaneous generation of .NO and superoxide by 3-morpholinosydnonimine (SIN-1, 0.1-2 mM) resulted in oxidation of dihydrorhodamine, a marker of peroxynitrite production, and a dose-dependent decrease in the ability of SP-A to enhance lipid aggregation. Superoxides 39-49 MAPK associated protein 1 Homo sapiens 78-83 8764220-8 1996 When cells were coincubated with SIN-1 plus superoxide dismutase, a technique designed to scavenge O2- and convert SIN-1 to purely an .NO-donor compound, Ca2+ signaling was identical to control. Superoxides 99-101 MAPK associated protein 1 Homo sapiens 33-38 7639707-4 1995 The difference in the efficacy of both NO-generating compounds could be due to the additional release of superoxide by SIN-1, since superoxide dismutase and the nitrone 5,5"-dimethyl pyrroline-1-oxide markedly inhibited the SIN-1-induced covalent binding of NAD+ to GAPDH. Superoxides 105-115 MAPK associated protein 1 Homo sapiens 119-124 7639707-4 1995 The difference in the efficacy of both NO-generating compounds could be due to the additional release of superoxide by SIN-1, since superoxide dismutase and the nitrone 5,5"-dimethyl pyrroline-1-oxide markedly inhibited the SIN-1-induced covalent binding of NAD+ to GAPDH. Superoxides 105-115 MAPK associated protein 1 Homo sapiens 224-229 1310595-3 1992 We have used 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a sydnonimine capable of generating both NO and superoxide simultaneously, to test this hypothesis. Superoxides 111-121 MAPK associated protein 1 Homo sapiens 55-60 1324680-4 1992 SIN-10 was more effective than SIN-1 in inhibiting superoxide anion (O2-) formation induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe) and by C5a. Superoxides 51-67 MAPK associated protein 1 Homo sapiens 0-5 1324680-4 1992 SIN-10 was more effective than SIN-1 in inhibiting superoxide anion (O2-) formation induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe) and by C5a. Superoxides 69-71 MAPK associated protein 1 Homo sapiens 0-5 8214120-7 1993 The observation that both SOD and SIN 1 inhibit leukocyte adhesion only under conditions associated with superoxide formation (HX-XO and PAF, but not LTB4) strongly suggests that the antiadhesion properties of NO are related to its ability to inactivate the superoxide anion. Superoxides 105-115 MAPK associated protein 1 Homo sapiens 34-39 1310595-4 1992 SIN-1 (1 mM) generated superoxide and NO at rates of 7.02 microM/min and 3.68 microM/min respectively in phosphate-buffered saline, pH 7.2, at 37 degrees C. Incubation of SIN-1 with both deoxyribose and sodium benzoate resulted in the formation of malondialdehyde (MDA). Superoxides 23-33 MAPK associated protein 1 Homo sapiens 0-5 1310595-10 1992 We conclude that the simultaneous production of NO and superoxide from SIN-1 results in the formation of hydroxyl radicals. Superoxides 55-65 MAPK associated protein 1 Homo sapiens 71-76 1332919-4 1992 In the present study we have modelled the simultaneous generation of superoxide and nitric oxide by using the sydnonimine, SIN-1 and have investigated its effects on LDL. Superoxides 69-79 MAPK associated protein 1 Homo sapiens 123-128 1332919-5 1992 SIN-1 liberates both superoxide and nitric oxide during autooxidation resulting in the formation of hydroxyl radicals. Superoxides 21-31 MAPK associated protein 1 Homo sapiens 0-5 1332919-6 1992 We have demonstrated that superoxide generated by SIN-1 is not available to take part in a dismutation reaction since it reacts preferentially with nitric oxide. Superoxides 26-36 MAPK associated protein 1 Homo sapiens 50-55 1332919-9 1992 The SIN-1-dependent peroxidation of LDL is completely inhibited by superoxide dismutase which scavenges superoxide. Superoxides 67-77 MAPK associated protein 1 Homo sapiens 4-9