PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10190138-4 1998 The permeabilized mast cells were stimulated to generate O2- by the addition of Ca2+, phospholipase A2 (PLA2) and arachidonic acid. Superoxides 57-59 phospholipase A2 group IB Rattus norvegicus 86-102 11994047-0 2002 Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. Superoxides 16-27 phospholipase A2 group IB Rattus norvegicus 118-134 15255947-7 2004 Phospholipase A2 inhibitors decrease the deregulation-related increase in superoxide without protecting against deregulation. Superoxides 74-84 phospholipase A2 group IB Rattus norvegicus 0-16 10662600-1 2000 Polychlorinated biphenyls (PCBs) activate neutrophils to induce degranulation and undergo superoxide production through a mechanism that involves stimulation of phospholipase A(2) (PLA(2)). Superoxides 90-100 phospholipase A2 group IB Rattus norvegicus 161-179 10662600-1 2000 Polychlorinated biphenyls (PCBs) activate neutrophils to induce degranulation and undergo superoxide production through a mechanism that involves stimulation of phospholipase A(2) (PLA(2)). Superoxides 90-100 phospholipase A2 group IB Rattus norvegicus 181-187 10190138-4 1998 The permeabilized mast cells were stimulated to generate O2- by the addition of Ca2+, phospholipase A2 (PLA2) and arachidonic acid. Superoxides 57-59 phospholipase A2 group IB Rattus norvegicus 104-108 7744303-0 1995 Lung damage in paraquat poisoning and hyperbaric oxygen exposure: superoxide-mediated inhibition of phospholipase A2. Superoxides 66-76 phospholipase A2 group IB Rattus norvegicus 100-116 8834862-2 1996 We undertook this study to determine whether phospholipase A2-dependent release of arachidonic acid is involved in PCB-induced O2- production. Superoxides 127-129 phospholipase A2 group IB Rattus norvegicus 45-61 8834862-11 1996 These data suggest that Aroclor 1242 stimulates neutrophils to produce O2- by a mechanism that involves phospholipase A2-dependent release of arachidonic acid. Superoxides 71-73 phospholipase A2 group IB Rattus norvegicus 104-120 7900800-2 1995 We found in rats subjected to intestinal I/R (ischemia 45 min and reperfusion 6 h) that 1) intestinal phospholipase A2 (PLA2) was activated during ischemia, 2) circulating PMN priming (assessed by superoxide production with N-formyl-Met-Leu-Phe) occurred after 1 h reperfusion, and 3) exaggerated 125I-labeled albumin lung leak occurred after 2 h reperfusion, compared with sham-treated animals (P < 0.05). Superoxides 197-207 phospholipase A2 group IB Rattus norvegicus 102-118 7900800-2 1995 We found in rats subjected to intestinal I/R (ischemia 45 min and reperfusion 6 h) that 1) intestinal phospholipase A2 (PLA2) was activated during ischemia, 2) circulating PMN priming (assessed by superoxide production with N-formyl-Met-Leu-Phe) occurred after 1 h reperfusion, and 3) exaggerated 125I-labeled albumin lung leak occurred after 2 h reperfusion, compared with sham-treated animals (P < 0.05). Superoxides 197-207 phospholipase A2 group IB Rattus norvegicus 120-124 7914788-7 1994 The protective activity of oxypurinol, amflutizole, superoxide dismutase, NG nitro-L-arginine and quinacrine, also suggests that xanthine oxidase activation, the generation of superoxide radical, and nitrix oxide, as well as phospholipase A2 stimulation are responsible for neuron injury (i.e. LDH release). Superoxides 176-194 phospholipase A2 group IB Rattus norvegicus 225-241 1337274-1 1992 The ability of the superoxide radical (SOR) generated by xanthine oxidase to activate phospholipase A2 (PLA2) was examined in microsomes prepared from luteinized rat ovaries. Superoxides 19-37 phospholipase A2 group IB Rattus norvegicus 86-102 8229768-2 1993 The purpose of this investigation was to study the role of phospholipase A2 (PLA2), arachidonic acid (AA), its metabolites, and protein kinase C (PKC) in the mechanism of PMA-stimulated O2- generation of liver infiltrated PMN as compared to circulating blood PMN. Superoxides 186-188 phospholipase A2 group IB Rattus norvegicus 59-75 8229768-2 1993 The purpose of this investigation was to study the role of phospholipase A2 (PLA2), arachidonic acid (AA), its metabolites, and protein kinase C (PKC) in the mechanism of PMA-stimulated O2- generation of liver infiltrated PMN as compared to circulating blood PMN. Superoxides 186-188 phospholipase A2 group IB Rattus norvegicus 77-81 1337274-1 1992 The ability of the superoxide radical (SOR) generated by xanthine oxidase to activate phospholipase A2 (PLA2) was examined in microsomes prepared from luteinized rat ovaries. Superoxides 19-37 phospholipase A2 group IB Rattus norvegicus 104-108 1337274-1 1992 The ability of the superoxide radical (SOR) generated by xanthine oxidase to activate phospholipase A2 (PLA2) was examined in microsomes prepared from luteinized rat ovaries. Superoxides 39-42 phospholipase A2 group IB Rattus norvegicus 86-102 1337274-1 1992 The ability of the superoxide radical (SOR) generated by xanthine oxidase to activate phospholipase A2 (PLA2) was examined in microsomes prepared from luteinized rat ovaries. Superoxides 39-42 phospholipase A2 group IB Rattus norvegicus 104-108 1664206-7 1991 These results suggest that the inhibitory mechanism of nifedipine and nisoldipine for O2- production from the macrophages appears to directly inhibit the enzyme system of the NADPH-oxidase complex through the activation of protein kinase C, and that the inhibition of PMA-stimulated PGE2 production may be due to a decrease of phospholipase A2 through protein kinase C. On the basis of the inhibitory action on O2- and PGE2 production from the macrophages, a possible mechanism of antiatherogenic effect of calcium antagonists was discussed. Superoxides 86-88 phospholipase A2 group IB Rattus norvegicus 327-343 1355540-4 1992 In rat isolated PMN leucocyte suspension, venom PLA2 induced superoxide radical formation. Superoxides 61-71 phospholipase A2 group IB Rattus norvegicus 48-52 3207972-19 1988 In conclusion, these data show that PLA2 (an enzyme involved in the synthesis of Paf-acether, prostaglandins, thromboxanes, leukotrienes, diacylglycerol, superoxide free radicals and lipid peroxides, etc.) Superoxides 154-164 phospholipase A2 group IB Rattus norvegicus 36-40 2548692-7 1989 These results indicate that the production of superoxide radical increases in plasma membrane samples prepared from regressing rat corpora lutea and that this increase is mainly due to the products of phospholipase A2 and cyclooxygenase activity. Superoxides 46-64 phospholipase A2 group IB Rattus norvegicus 201-217