PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16701555-5 2006 When we then exposed myocytes to the superoxide generator menadione, we observed significantly higher death of MEK-EE expressing myocytes. Superoxides 37-47 mitogen-activated protein kinase kinase 7 Homo sapiens 111-114 22213462-13 2012 These findings suggest that the superoxide anion-MEK-ERK-MLCK-MLC signaling mediates IS-induced junctional dispersal of BPAECs. Superoxides 32-48 mitogen-activated protein kinase kinase 7 Homo sapiens 49-52 14505347-4 2003 Taken together, hydrogen peroxide (H(2)O(2)) rather than superoxide anion (O(2) (*-)) acts as a second messenger of metabolic oxidative stress to activate the ASK1-MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-mitogen-activated protein kinase (MAPK) signal transduction pathway. Superoxides 39-43 mitogen-activated protein kinase kinase 7 Homo sapiens 221-224 15485492-5 2004 These effects depended on the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK1/2) pathway, as the specific MEK inhibitor, PD98059, prevented HaRas-mediated increase in ROS and superoxide anions. Superoxides 215-232 mitogen-activated protein kinase kinase 7 Homo sapiens 109-112 15485492-5 2004 These effects depended on the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK1/2) pathway, as the specific MEK inhibitor, PD98059, prevented HaRas-mediated increase in ROS and superoxide anions. Superoxides 215-232 mitogen-activated protein kinase kinase 7 Homo sapiens 146-149 12083801-9 2002 In this study, we for the first time demonstrate a novel mechanism, independent of Ras activation but initiated by superoxide anion production, for PPARgamma agonists to trigger the Raf-MEK-ERK1/2 signaling pathway. Superoxides 115-131 mitogen-activated protein kinase kinase 7 Homo sapiens 186-189 31811262-9 2019 Taken together, our results suggest that eugenol inhibits the generation of superoxide anion by neutrophils via the inhibition of Raf/MEK/ERK1/2/p47phox-phosphorylation pathway. Superoxides 76-86 mitogen-activated protein kinase kinase 7 Homo sapiens 134-137 9766635-9 1998 TNF-alpha and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly attenuated by the MEK inhibitor, PD098059, and the p38 MAPK inhibitor, SB203580. Superoxides 32-42 mitogen-activated protein kinase kinase 7 Homo sapiens 141-144 12083801-0 2002 Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. Superoxides 0-16 mitogen-activated protein kinase kinase 7 Homo sapiens 31-34