PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24853984-5	2014	Hirsutenone-mediated protection against the loss of ZO-1 depends on the activation of both ERK1/2 and Akt signaling pathways.	hirsutenone	0-11	mitogen-activated protein kinase 3	Mus musculus	91-97	
24853984-7	2014	Hirsutenone increased heme oxygenase-1 (HO-1) expression through both EGFR/Akt- and ERK1/2-dependent pathways, contributing to the protective effects against TJ dysfunction.	hirsutenone	0-11	mitogen-activated protein kinase 3	Mus musculus	84-90	
24853984-10	2014	Taken together, our results demonstrate that hirsutenone reverse disordered intestinal permeability by activating EGFR/Akt and ERK1/2 pathways, which are involved in the regulation of HO-1 expression.	hirsutenone	45-56	mitogen-activated protein kinase 3	Mus musculus	127-133	
24853984-0	2014	Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction.	hirsutenone	0-11	mitogen-activated protein kinase 3	Mus musculus	82-88