PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24100378-11 2013 The present results propose the possibility that PSK induces PBMCs to express IFN-alpha which inhibits DPD expression, and consequently augments the antitumor effect of 5-FU or 5"-DFUR. doxifluridine 177-184 interferon alpha 1 Homo sapiens 78-87 24219283-6 2013 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. doxifluridine 176-180 interferon alpha 1 Homo sapiens 33-60 24219283-6 2013 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. doxifluridine 176-180 interferon alpha 1 Homo sapiens 51-60 24219283-6 2013 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. doxifluridine 271-275 interferon alpha 1 Homo sapiens 33-60 24219283-6 2013 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. doxifluridine 271-275 interferon alpha 1 Homo sapiens 51-60 17988526-1 2007 OBJECTIVE: To observe changes of sensitivity to 5"-deoxy-5-fluorouridine (5"-dFUrd), and 5-fluorouracil (5-FU) in SMMC-7721 hepatocellular carcinoma cells by interferon alpha (IFN-alpha), and its relationship with the expression of thymidine phosphorylase (TP). doxifluridine 48-72 interferon alpha 1 Homo sapiens 176-185 17988526-1 2007 OBJECTIVE: To observe changes of sensitivity to 5"-deoxy-5-fluorouridine (5"-dFUrd), and 5-fluorouracil (5-FU) in SMMC-7721 hepatocellular carcinoma cells by interferon alpha (IFN-alpha), and its relationship with the expression of thymidine phosphorylase (TP). doxifluridine 74-82 interferon alpha 1 Homo sapiens 176-185 17988526-7 2007 IFN-alpha enhanced the sensitivity of SMMC-7721 cells to 5"-dFUrd with dose-dependent increase. doxifluridine 57-65 interferon alpha 1 Homo sapiens 0-9 17988526-8 2007 IFN-alpha (10 000 U/ml) reduced IC(50) of 5"-dFUrd from (102.1 +/- 18.4) micromol/L to (34.2 +/- 4.1) micromol/L (P < 0.05). doxifluridine 42-50 interferon alpha 1 Homo sapiens 0-9 17988526-12 2007 CONCLUSION: IFN-alpha enhanced cytotoxicity of 5"-dFUrd against SMMC-7721 cells positively related to its induction of TP mRNA. doxifluridine 47-55 interferon alpha 1 Homo sapiens 12-21