PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8527457-2	1995	The effect of caldesmon (CaD) on local conformational changes in different regions of the tropomyosin molecule was determined on the basis of changes in the excimer fluorescence (excited dimer of pyrene) formed in homodimers of tropomyosin isoforms.	pyrene	196-202	caldesmon 1	Homo sapiens	14-23	
8527457-2	1995	The effect of caldesmon (CaD) on local conformational changes in different regions of the tropomyosin molecule was determined on the basis of changes in the excimer fluorescence (excited dimer of pyrene) formed in homodimers of tropomyosin isoforms.	pyrene	196-202	caldesmon 1	Homo sapiens	25-28	
8527457-3	1995	In the absence of actin, excimer fluorescence from the pyrene at Cys-190 of gamma-tropomyosin homodimer decreased in a simple manner on the addition of CaD, whereas the excimer from the Cys-36 of beta-tropomyosin homodimer exhibited a biphasic change, suggesting that additional weak binding sites exist near Cys-36.	pyrene	55-61	caldesmon 1	Homo sapiens	152-155	
3242591-6	1988	Tropomyosin induced a change in the fluorescence spectrum of pyrene-caldesmon, indicating a conformational change associated with the interaction between caldesmon and tropomyosin.	pyrene	61-67	caldesmon 1	Homo sapiens	154-163	
8567938-2	1995	The bent "hairpin" form of caldesmon was enhanced between pH 6.0 and 8.0 and at low ionic strengths, as reported by an increase in excimer fluorescence of pyrene-labelled caldesmon under these conditions.	pyrene	155-161	caldesmon 1	Homo sapiens	27-36	
8567938-2	1995	The bent "hairpin" form of caldesmon was enhanced between pH 6.0 and 8.0 and at low ionic strengths, as reported by an increase in excimer fluorescence of pyrene-labelled caldesmon under these conditions.	pyrene	155-161	caldesmon 1	Homo sapiens	171-180	
8567938-4	1995	Titrations of pyrene caldesmon with actin, heavy meromyosin, and calmodulin resulted in a decrease in excimer fluorescence.	pyrene	14-20	caldesmon 1	Homo sapiens	21-30	
3242591-2	1988	The number of sulfhydryl (SH) groups in caldesmon was around 3.5 on the basis of reactivity to 5,5"-dithiobis(2-nitrobenzoate); 80% of the SH groups were labeled with pyrene.	pyrene	167-173	caldesmon 1	Homo sapiens	40-49	
3242591-3	1988	The fluorescence spectrum from pyrene-caldesmon showed the presence of excited monomer and dimer (excimer).	pyrene	31-37	caldesmon 1	Homo sapiens	38-47	
3242591-5	1988	The labeling of caldesmon with pyrene did not affect its ability to inhibit actin activation of heavy meromyosin Mg-ATPase and the release of this inhibition in the presence of Ca2+-calmodulin.	pyrene	31-37	caldesmon 1	Homo sapiens	16-25	
3242591-6	1988	Tropomyosin induced a change in the fluorescence spectrum of pyrene-caldesmon, indicating a conformational change associated with the interaction between caldesmon and tropomyosin.	pyrene	61-67	caldesmon 1	Homo sapiens	68-77	
3242591-10	1988	The addition of tropomyosin also changed the fluorescence spectrum of pyrene-caldesmon bound to actin filaments.	pyrene	70-76	caldesmon 1	Homo sapiens	77-86	
3242591-11	1988	The change in the conformation of tropomyosin, caused by the interaction between caldesmon and tropomyosin, was studied with pyrene-labeled tropomyosin.	pyrene	125-131	caldesmon 1	Homo sapiens	81-90	
19889635-3	2010	We have studied the effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin.	pyrene	153-159	caldesmon 1	Homo sapiens	55-58