PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8634092-0	1996	Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells.	pyrene	51-57	tumor protein p53	Homo sapiens	31-34	
23192191-2	2012	In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods.	pyrene	47-53	tumor protein p53	Homo sapiens	113-116	
8430068-1	1993	Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P).	pyrene	225-231	tumor protein p53	Homo sapiens	118-121	
29471073-0	2018	The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.	pyrene	112-118	tumor protein p53	Homo sapiens	155-159	
28187856-0	2017	Corrigendum to "PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a" [Chem.	pyrene	66-72	tumor protein p53	Homo sapiens	81-84	
23192191-6	2012	Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA.	pyrene	24-30	tumor protein p53	Homo sapiens	46-49	
7766306-0	1995	Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.	pyrene	8-14	tumor protein p53	Homo sapiens	38-41	
7766306-1	1995	Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene.	pyrene	227-233	tumor protein p53	Homo sapiens	120-123	
7766306-2	1995	To gain insight into the mechanism of formation of these G-to-T transversions in tobacco-associated carcinogenesis, we studied the mutagenesis of p53 codons 247-250 by benzo[a]pyrene in human hepatocellular carcinoma cells by restriction fragment length polymorphism-polymerase chain reaction genotypic analysis.	pyrene	176-182	tumor protein p53	Homo sapiens	146-149	
17029827-3	2006	The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity.	pyrene	86-92	tumor protein p53	Homo sapiens	4-7	
21911080-0	2011	Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells.	pyrene	8-14	tumor protein p53	Homo sapiens	67-70	
20840854-0	2010	Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis.	pyrene	43-49	tumor protein p53	Homo sapiens	58-61	
17029827-3	2006	The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity.	pyrene	86-92	tumor protein p53	Homo sapiens	124-127	
17029827-3	2006	The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity.	pyrene	181-187	tumor protein p53	Homo sapiens	4-7	
17029827-3	2006	The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity.	pyrene	181-187	tumor protein p53	Homo sapiens	124-127	
15595848-0	2004	Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene.	pyrene	31-37	tumor protein p53	Homo sapiens	95-98	
15805253-0	2005	p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors.	pyrene	25-31	tumor protein p53	Homo sapiens	0-3	
15805253-0	2005	p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors.	pyrene	25-31	tumor protein p53	Homo sapiens	46-49	
15854413-0	2005	[Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells].	pyrene	119-125	tumor protein p53	Homo sapiens	17-20