PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8634092-0 1996 Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells. pyrene 51-57 tumor protein p53 Homo sapiens 31-34 23192191-2 2012 In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. pyrene 47-53 tumor protein p53 Homo sapiens 113-116 8430068-1 1993 Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P). pyrene 225-231 tumor protein p53 Homo sapiens 118-121 29471073-0 2018 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. pyrene 112-118 tumor protein p53 Homo sapiens 155-159 28187856-0 2017 Corrigendum to "PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a" [Chem. pyrene 66-72 tumor protein p53 Homo sapiens 81-84 23192191-6 2012 Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. pyrene 24-30 tumor protein p53 Homo sapiens 46-49 7766306-0 1995 Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes. pyrene 8-14 tumor protein p53 Homo sapiens 38-41 7766306-1 1995 Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene. pyrene 227-233 tumor protein p53 Homo sapiens 120-123 7766306-2 1995 To gain insight into the mechanism of formation of these G-to-T transversions in tobacco-associated carcinogenesis, we studied the mutagenesis of p53 codons 247-250 by benzo[a]pyrene in human hepatocellular carcinoma cells by restriction fragment length polymorphism-polymerase chain reaction genotypic analysis. pyrene 176-182 tumor protein p53 Homo sapiens 146-149 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 86-92 tumor protein p53 Homo sapiens 4-7 21911080-0 2011 Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. pyrene 8-14 tumor protein p53 Homo sapiens 67-70 20840854-0 2010 Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis. pyrene 43-49 tumor protein p53 Homo sapiens 58-61 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 86-92 tumor protein p53 Homo sapiens 124-127 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 181-187 tumor protein p53 Homo sapiens 4-7 17029827-3 2006 The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important roles in the defense against benzo[a]pyrene-induced genotoxicity. pyrene 181-187 tumor protein p53 Homo sapiens 124-127 15595848-0 2004 Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene. pyrene 31-37 tumor protein p53 Homo sapiens 95-98 15805253-0 2005 p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. pyrene 25-31 tumor protein p53 Homo sapiens 0-3 15805253-0 2005 p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. pyrene 25-31 tumor protein p53 Homo sapiens 46-49 15854413-0 2005 [Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells]. pyrene 119-125 tumor protein p53 Homo sapiens 17-20