PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15016593-4	2004	The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation.	pyrene	4-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	122-136	
15958554-6	2005	CYP1B1.7, having the amino acid substitutions Arg48Gly, Ala119Ser, Leu432Val, and Ala443Gly, exhibited a significantly decreased capacity (P < 0.001) for the formation of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol from benzo[a]pyrene as indicated by lower intrinsic clearance (Vmax/Km).	pyrene	185-191	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
12624000-3	2003	Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism.	pyrene	69-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	87-93	
12624000-3	2003	Ellipticine, alpha-naphthoflavone (selective CYP1A1 inhibitors), and pyrene (selective CYP1B1 inhibitor), but not ketoconazole (selective CYP3A4 inhibitor) or furafylline (selective CYP1A2 inhibitor), abrogated the inhibitor effects of estradiol on cell activity, a profile consistent with a CYP1A1/CYP1B1-mediated mechanism.	pyrene	69-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	299-305	
35307418-4	2022	Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1, CYP1B1, AHR, ARNT.	pyrene	48-51	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	272-278	
9106248-9	1997	In order to begin to characterize the promutagen activating ability of CYP1B1, the mutagenicity of selected chemicals was examined in h1B1/OR cells; there was increased sensitivity (CYP1B1-expressing relative to control cells) to the mutagenicity of benzo(a)pyrene, cyclopenta(c,d)pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and aflatoxin B1 (AFB).	pyrene	257-264	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	71-77	
26247835-5	2016	Of five other human P450s examined, P450 1B1 catalyzed pyrene oxidation to 1-hydroxypyrene at a similar rate to P450 2A13 but was less efficient in forming dihydroxypyrenes.	pyrene	55-61	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	36-44	
31687396-7	2019	Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2.	pyrene	0-6	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	81-87	
26247835-11	2016	In addition, Phe-231 and Gly-329 were found to interact with pyrene to orient this compound in the active site of P450 1B1.	pyrene	61-67	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	114-122	
19563207-0	2009	Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.	pyrene	92-98	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	40-59	
19563207-6	2009	Pyrene itself was highly active in interacting with P450 1B1, but its binding was slightly decreased when substituted with acetylenic groups.	pyrene	0-6	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	52-60