PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26496743-9	2016	RT-PCR confirmed expression changes in several genes related to apoptosis, iron metabolism, and aryl hydrocarbon receptor signaling that are regulated in the opposite direction during spleen atrophy versus benzo[a]pyrene-mediated splenomegaly.	pyrene	214-220	aryl-hydrocarbon receptor	Mus musculus	96-121	
35405096-8	2022	Notably, we confirmed that a regulatory axis, PP2A B56alpha-AHR-Cyp1a1 was involved in benzo(a)pyrene-induced cytotoxicity through dephosphorylation of the metabolic nuclear receptor AHR at Ser36.	pyrene	95-101	aryl-hydrocarbon receptor	Mus musculus	60-63	
35405096-8	2022	Notably, we confirmed that a regulatory axis, PP2A B56alpha-AHR-Cyp1a1 was involved in benzo(a)pyrene-induced cytotoxicity through dephosphorylation of the metabolic nuclear receptor AHR at Ser36.	pyrene	95-101	aryl-hydrocarbon receptor	Mus musculus	183-186	
22228805-0	2012	Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice.	pyrene	21-27	aryl-hydrocarbon receptor	Mus musculus	49-74	
20478378-1	2010	We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs).	pyrene	193-199	aryl-hydrocarbon receptor	Mus musculus	39-64	
20478378-1	2010	We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs).	pyrene	193-199	aryl-hydrocarbon receptor	Mus musculus	66-69	
17618724-6	2007	In contrast, pyrene exposure increased expression of the UGT1A1 and 1A6, and glucuronidation activities associated with 1-hydroxypyrene and 1-naphthol in the liver only in AhR (-/-) mice, although pyrene treatment dose-dependently decreased the latter activity.	pyrene	13-19	aryl-hydrocarbon receptor	Mus musculus	172-175	
17618724-8	2007	In contrast, pyrene-induced expression of the hepatic constitutive androstane receptor (CAR) and one of its target genes, CYP2B10, in both AhR (+/+) and (-/-) mice.	pyrene	13-19	aryl-hydrocarbon receptor	Mus musculus	139-142	
17618724-9	2007	These results strongly suggest that pyrene-induced CYP1A2 and SULT1A1 are regulated by CAR, not by AhR.	pyrene	36-42	aryl-hydrocarbon receptor	Mus musculus	99-102	
15888666-1	2005	Hepa-1c1c7 wild-type and benzo[a]pyrene-resistant derived mutant cell lines have been used to elucidate pathways and mechanisms involving the aryl hydrocarbon receptor (AhR).	pyrene	33-39	aryl-hydrocarbon receptor	Mus musculus	142-167	
15888666-1	2005	Hepa-1c1c7 wild-type and benzo[a]pyrene-resistant derived mutant cell lines have been used to elucidate pathways and mechanisms involving the aryl hydrocarbon receptor (AhR).	pyrene	33-39	aryl-hydrocarbon receptor	Mus musculus	169-172	
15034205-0	2004	Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice.	pyrene	53-59	aryl-hydrocarbon receptor	Mus musculus	112-115	
14645679-5	2003	Using Northern blots, we then confirmed that nickel can down-regulate both the basal and benzo[a]pyrene-inducible expression of AhR-dependent genes in mouse and human cell lines.	pyrene	97-103	aryl-hydrocarbon receptor	Mus musculus	128-131	
17618724-2	2007	To determine whether pyrene-induced xenobiotic-metabolizing enzymes are regulated by AhR, male AhR (+/+) and (-/-) mice were used.	pyrene	21-27	aryl-hydrocarbon receptor	Mus musculus	85-88	
17618724-4	2007	Exposure to pyrene did not influence hepatic CYP1A1-mRNA in mice of both genotypes, whereas it induced hepatic CYP1A2 protein and mRNA expression and associated 7-ethoxyresorufin O-deethylase and pyrene 1-hydroxylation activities in both AhR (+/+) and (-/-) mice.	pyrene	12-18	aryl-hydrocarbon receptor	Mus musculus	238-241