PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21556275-7	2011	Nine of these pathways were shared with those enriched in the genes regulated by nicotine, including neuronal function-related pathways such as glucocorticoid receptor signaling, p38 MAPK signaling, PI3K/AKT signaling, and PTEN signaling, implying that nAChRs play important roles in the regulation of these biological processes.	Nicotine	81-89	phosphatase and tensin homolog	Homo sapiens	223-227	
17465209-2	2007	The phosphatidylinositol 3-kinase (PI3-K)/Akt/PTEN pathway has been suggested to play a role in the antiapoptotic responses to nicotine.	Nicotine	127-135	phosphatase and tensin homolog	Homo sapiens	46-50	
32106059-3	2020	rSLURP-1 fully abolished the nicotine-induced increase of the cell proliferation, down-regulation of the expression of PTEN (the negative regulator of the AKT pathway, controlling the growth, survival, and proliferation of cancer cells), and up-regulation of the alpha7-nAChR expression in the A549 cells.	Nicotine	29-37	phosphatase and tensin homolog	Homo sapiens	119-123