PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30260034-6 2019 Continuous exposure to the mixture of 0.15 muM nicotine and 2 muM cotinine retarded pterygium cell proliferation by 16.04% (P = 0.009) and hindered their migration by 11.93% ( P = 0.039), without affecting cell apoptosis. Nicotine 47-55 latexin Homo sapiens 43-46 30260034-7 2019 SNAIL and alpha-smooth muscle actin protein expression was significantly downregulated in pterygium cells treated with 0.15 muM nicotine-2 muM cotinine mixture by 1.33- ( P = 0.036) and 1.31-fold ( P = 0.001), respectively. Nicotine 128-136 latexin Homo sapiens 124-127 30260034-7 2019 SNAIL and alpha-smooth muscle actin protein expression was significantly downregulated in pterygium cells treated with 0.15 muM nicotine-2 muM cotinine mixture by 1.33- ( P = 0.036) and 1.31-fold ( P = 0.001), respectively. Nicotine 128-136 latexin Homo sapiens 139-142 30260034-8 2019 Besides, the 0.15 muM nicotine-2 muM cotinine mixture also reduced matrix metalloproteinase (MMP)-1 and MMP-9 expressions in pterygium cells by 1.56- ( P = 0.043) and 1.27-fold ( P = 0.012), respectively. Nicotine 22-30 latexin Homo sapiens 18-21 30260034-8 2019 Besides, the 0.15 muM nicotine-2 muM cotinine mixture also reduced matrix metalloproteinase (MMP)-1 and MMP-9 expressions in pterygium cells by 1.56- ( P = 0.043) and 1.27-fold ( P = 0.012), respectively. Nicotine 22-30 latexin Homo sapiens 33-36 28372298-7 2017 The proliferation of hWJ-MSCs with 5 muM nicotine was measured by the MTT assay on the 1st, 2nd, 3rd, and 6th day. Nicotine 41-49 latexin Homo sapiens 37-40 28372298-13 2017 RESULTS: The proliferation of hWJ-MSCs was significantly impaired by nicotine (5 muM) from the 3rd day of treatment, but nicotine did not significantly induce modifications on the viability of hWJ-MSCs. Nicotine 69-77 latexin Homo sapiens 81-84 27698409-6 2016 Glutamatergic N398 neurons responded to lower nicotine doses (0.1 muM) with greater frequency and amplitude but they also exhibited rapid desensitization, consistent with previous analyses of N398-associated nicotinic receptor function. Nicotine 46-54 latexin Homo sapiens 66-69 27805736-5 2017 Varenicline and nicotine activated alpha3beta4* nAChRs with EC50 values of 1.8 (1.2-2.7) muM and 19.4 (11.1-33.9) muM, respectively. Nicotine 16-24 latexin Homo sapiens 89-92 27805736-5 2017 Varenicline and nicotine activated alpha3beta4* nAChRs with EC50 values of 1.8 (1.2-2.7) muM and 19.4 (11.1-33.9) muM, respectively. Nicotine 16-24 latexin Homo sapiens 114-117 26320635-6 2015 A very low concentration of Ru(bpy)32+, namely 9 muM, was demonstrated to be enough for achieving the sensitive detection of TPrA, nicotine and atropine. Nicotine 131-139 latexin Homo sapiens 49-52 26441658-7 2015 At 100 muM, it activated 16% of the maximal current activated by nicotine. Nicotine 65-73 latexin Homo sapiens 7-10 26441658-10 2015 In contrast, NNN was a pure inhibitor of this nAChR subtype, with IC50 of approximately 1 nM in the presence of 10 muM nicotine. Nicotine 119-127 latexin Homo sapiens 115-118 24201001-2 2014 We found that combined exposure to relevant exposure concentrations of ethanol (2%) and nicotine (15 muM) induces an increase in the amount of reactive oxygen species (ROS). Nicotine 88-96 latexin Homo sapiens 101-104 24581246-9 2014 In contrast, nicotine had anti-inflammatory properties (0.6 fold IL-8 release after 50 muM exposure to nicotine for 24 h), and acetylaldehyde was without effect. Nicotine 13-21 latexin Homo sapiens 87-90 24581246-9 2014 In contrast, nicotine had anti-inflammatory properties (0.6 fold IL-8 release after 50 muM exposure to nicotine for 24 h), and acetylaldehyde was without effect. Nicotine 103-111 latexin Homo sapiens 87-90 24599396-7 2014 RESULTS: Nicotine (100 and 200 muM) microinjected into the pVTA enhanced EtOH seeking. Nicotine 9-17 latexin Homo sapiens 31-34 24599396-8 2014 Coinfusion with 200 muM mecamylamine (nACh antagonist) or 100 and 200 muM zacopride (5-HT3 receptor antagonist) blocked the observed nicotine enhancement of EtOH seeking. Nicotine 133-141 latexin Homo sapiens 20-23 24599396-8 2014 Coinfusion with 200 muM mecamylamine (nACh antagonist) or 100 and 200 muM zacopride (5-HT3 receptor antagonist) blocked the observed nicotine enhancement of EtOH seeking. Nicotine 133-141 latexin Homo sapiens 70-73 24698733-3 2014 Therefore, primary salivary gland cells from 10 patients undergoing parotid gland surgery were exposed to nicotine concentrations between 1 muM and 1000 muM for 1 h in the absence of exogenous metabolic activation. Nicotine 106-114 latexin Homo sapiens 140-143 24698733-3 2014 Therefore, primary salivary gland cells from 10 patients undergoing parotid gland surgery were exposed to nicotine concentrations between 1 muM and 1000 muM for 1 h in the absence of exogenous metabolic activation. Nicotine 106-114 latexin Homo sapiens 153-156 22349182-2 2012 Cultured human endothelial cells were exposed to 1 muM nicotine for 5 days. Nicotine 55-63 latexin Homo sapiens 51-54 22281529-2 2012 In trigeminal neurons (TG), we found that nicotine (75 muM)-activated whole-cell currents through nAChRs were reversibly reduced by menthol in a concentration-dependent manner with an IC50 of 111 muM. Nicotine 42-50 latexin Homo sapiens 55-58 22281529-2 2012 In trigeminal neurons (TG), we found that nicotine (75 muM)-activated whole-cell currents through nAChRs were reversibly reduced by menthol in a concentration-dependent manner with an IC50 of 111 muM. Nicotine 42-50 latexin Homo sapiens 196-199 22155207-3 2012 In isolated porcine endothelium-denuded basilar arteries in the presence of U-46619-induced active muscle tone, fluoxetine in low concentration (<0.03 muM) significantly enhanced nicotine- and choline-induced relaxations. Nicotine 182-190 latexin Homo sapiens 154-157 22155207-7 2012 In addition, fluoxetine at 0.03 muM and 3 muM significantly enhanced and blocked, respectively, nicotine-induced norepinephrine (NE) release from cerebral perivascular sympathetic nerves. Nicotine 96-104 latexin Homo sapiens 32-35 22155207-7 2012 In addition, fluoxetine at 0.03 muM and 3 muM significantly enhanced and blocked, respectively, nicotine-induced norepinephrine (NE) release from cerebral perivascular sympathetic nerves. Nicotine 96-104 latexin Homo sapiens 42-45 21889975-5 2011 Nicotine treatment (0.01-1 muM) for up to 48 h had little or no effect upon the TEER or sucrose permeability of either ECV304/C6 co-cultures or CaCo2 cells. Nicotine 0-8 latexin Homo sapiens 27-30 16076763-4 2005 Nicotine (1 and 10 muM) significantly induced DNA strand breakage when cultured at pH 8 for 6 h but did not induce DNA damage at pH 6.5. Nicotine 0-8 latexin Homo sapiens 19-22 21222065-5 2011 Pre-exposure of SH-SY5Y cells to either ethanol (1 or 10 mM) or nicotine (20 or 50 muM) significantly attenuated salsolinol-induced toxicity. Nicotine 64-72 latexin Homo sapiens 83-86 21370452-5 2011 The alpha9-nAChR promoter activity is significantly induced by 24-h treatment with Nic (10 muM) or E2 (10 nM) (>1.8 and ~2.3-fold, respectively) in MCF-7 cells. Nicotine 83-86 latexin Homo sapiens 91-94 20708605-8 2010 The secreted Abeta was decreased and alphaAPPs was significantly increased by non-selective nAChR agonist nicotine (10 muM) and specific alpha7 nAChR agonist GTS-21 (1 muM), and APP expression was not affected. Nicotine 106-114 latexin Homo sapiens 119-122 20708605-10 2010 CTF-alpha was increased and CTF-gamma was decreased when treated with nicotine (10 muM). Nicotine 70-78 latexin Homo sapiens 83-86 20708605-11 2010 In addition, the results of enymatic activity analysis showed that nicotine (1muM) and GTS-21 (0.1, 1 muM) decreased gamma-secretase activity, but has no effects on alpha-secretase activity and beta-secretase activity. Nicotine 67-75 latexin Homo sapiens 78-81 17912626-9 2008 (3) Human amyloid precursor protein (695) gene was stably expressed in SH-EP1-alpha4beta2 cells; Nicotine (1 muM) and epibatidine (0.1 muM) decreased intracellular and secreted beta-amyloid in the cells; and activation of alpha4beta2 receptors did not affect amyloid precursor protein (695) mRNA level. Nicotine 97-105 latexin Homo sapiens 109-112 17912626-9 2008 (3) Human amyloid precursor protein (695) gene was stably expressed in SH-EP1-alpha4beta2 cells; Nicotine (1 muM) and epibatidine (0.1 muM) decreased intracellular and secreted beta-amyloid in the cells; and activation of alpha4beta2 receptors did not affect amyloid precursor protein (695) mRNA level. Nicotine 97-105 latexin Homo sapiens 135-138 16076763-7 2005 Flow cytometric analyses showed that the production of 8-oxoguanine was significantly increased following nicotine (10 muM) treatment. Nicotine 106-114 latexin Homo sapiens 119-122 16076763-10 2005 Finally, cigarette smoke condensate (equivalent to 8 muM nicotine) induced significant DNA strand breaks in OEC-M1 cells at pH 8 and correlated with the generation of oxidative DNA damage. Nicotine 57-65 latexin Homo sapiens 53-56 31953160-4 2020 MATERIALS AND METHODS: Primary human PSCs were cultured and treated with nicotine (0.1 muM and 1 muM). Nicotine 73-81 latexin Homo sapiens 87-90 32276728-9 2020 Nicotine 1 muM down-regulated cardiac progenitor cell, mesoderm cell, smooth muscle cell and neural crest cell relatively. Nicotine 0-8 latexin Homo sapiens 11-14 31953160-7 2020 KEY FINDINGS: The proliferation, alpha-SMA expression and autophagy of hPSCs were significantly promoted by 1 muM nicotine. Nicotine 114-122 latexin Homo sapiens 110-113