PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28440100-8 2017 Moreover, nicotine increased the mRNA levels of TAA-induced transforming growth factor-beta (TGF-beta) and collagen type I alpha 1 in the liver. Nicotine 10-18 transforming growth factor beta 1 Homo sapiens 93-101 7923576-1 1994 The direct effect of nicotine on the expression of receptors for the tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta (TGF beta) and the internalization, intracellular distribution and stability of these growth factors in cervical cancer cell line SiHa was studied. Nicotine 21-29 transforming growth factor beta 1 Homo sapiens 113-144 7923576-1 1994 The direct effect of nicotine on the expression of receptors for the tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta (TGF beta) and the internalization, intracellular distribution and stability of these growth factors in cervical cancer cell line SiHa was studied. Nicotine 21-29 transforming growth factor beta 1 Homo sapiens 146-154 7923576-3 1994 Nicotine at 0.1% stabilized and protected from degradation [125I]TNF alpha and [125I]TGF beta internalized by cervical cancer SiHa cell line. Nicotine 0-8 transforming growth factor beta 1 Homo sapiens 85-93 7923576-6 1994 In the presence of nicotine, both [125I]TNF alpha and [125I]TGF beta were detected in high quantities and in a non-degraded form in the cytoplasm and chromatin during 5 days of incubation. Nicotine 19-27 transforming growth factor beta 1 Homo sapiens 60-68 7923576-7 1994 In addition to the lack of growth factor degradation, the presence of nicotine induced a nuclear accumulation of growth factors, with up to 37% of the internalized [125I]TGF beta being in the chromatin. Nicotine 70-78 transforming growth factor beta 1 Homo sapiens 170-178 7923576-8 1994 An increased intracellular accumulation of [125I]TNF alpha and [125I]TGF beta in cells exposed to nicotine occurred without changes in expression of the cell surface receptors. Nicotine 98-106 transforming growth factor beta 1 Homo sapiens 69-77 23204070-6 2013 We also noted that the release of TGF-beta(1) from these cells was stimulated by nicotine. Nicotine 81-89 transforming growth factor beta 1 Homo sapiens 34-45 25316032-8 2016 As a result, following treatment with 1 mug/ml nicotine, tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta1 production in both cell lysates and supernatants, and matrix metalloproteinases-1 production in cell lysates, were significantly increased (p < 0.05). Nicotine 47-55 transforming growth factor beta 1 Homo sapiens 57-133 24756761-0 2014 Nicotine upregulates microRNA-21 and promotes TGF-beta-dependent epithelial-mesenchymal transition of esophageal cancer cells. Nicotine 0-8 transforming growth factor beta 1 Homo sapiens 46-54 24756761-6 2014 Moreover, the upregulated miR-21 by nicotine promoted EMT transforming growth factor beta (TGF-beta) dependently. Nicotine 36-44 transforming growth factor beta 1 Homo sapiens 91-99 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 90-98 transforming growth factor beta 1 Homo sapiens 35-46 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 90-98 transforming growth factor beta 1 Homo sapiens 52-63 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 90-98 transforming growth factor beta 1 Homo sapiens 52-63 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 154-162 transforming growth factor beta 1 Homo sapiens 35-46 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 154-162 transforming growth factor beta 1 Homo sapiens 52-63 23204070-8 2013 Furthermore, specific knockdown of TGF-beta(1) with TGF-beta(1) siRNA partially prevented nicotine-induced EMT, suggesting that TGF-beta(1) has a role in nicotine-mediated EMT in HBECs. Nicotine 154-162 transforming growth factor beta 1 Homo sapiens 52-63 18618634-8 2008 In all groups, nicotine reduced LPS- and PHA (0.5 microg/mL)-stimulated production of IL1beta, IL10, TGFbeta, and TNFalpha (P < 0.001). Nicotine 15-23 transforming growth factor beta 1 Homo sapiens 101-108 15727570-11 2005 The VEGF-C levels were significantly increased, while TGF-beta levels were decreased by nicotine in all the cell lines (P < 0.00001). Nicotine 88-96 transforming growth factor beta 1 Homo sapiens 54-62 15727570-13 2005 CONCLUSIONS: Nicotine up regulates expression of cell proliferative VEGF-C and EGF-R, while down-regulating anti-proliferative TGF-beta. Nicotine 13-21 transforming growth factor beta 1 Homo sapiens 127-135 22108052-6 2012 Nicotine induction of hHSC proliferation, upregulation of collagen1-alpha2 and the pro-fibrogenic cytokine transforming growth factor beta 1 (TGF-beta1) was determined along with involved intracellular signaling pathways. Nicotine 0-8 transforming growth factor beta 1 Homo sapiens 142-151 22108052-11 2012 Additionally, collagen1-alpha2 and TGF-beta1 mRNA expression were significantly upregulated by nicotine and inhibited by mecamylamine. Nicotine 95-103 transforming growth factor beta 1 Homo sapiens 35-44 16401677-9 2006 Nicotine in cigarette smoke activated mast cells and induced TGF-beta1 expression in cultured fibroblasts. Nicotine 0-8 transforming growth factor beta 1 Homo sapiens 61-70 15962330-8 2005 TGF-beta1 induced an increase of alpha-SMA protein and mRNA expression, while nicotine (1 mM) inhibited the TGF-beta1-induced expression of alpha-SMA but not beta-actin. Nicotine 78-86 transforming growth factor beta 1 Homo sapiens 108-117 15962330-9 2005 Nicotine treatment down-regulated TGF-beta1-induced p38 MAPK phosphorylation. Nicotine 0-8 transforming growth factor beta 1 Homo sapiens 34-43